Double Incretin Receptor Knockout (DIRKO) Mice Reveal an Essential Role for the Enteroinsular Axis in Transducing the Glucoregulatory Actions of DPP-IV Inhibitors - Hansotia, Tanya; Baggio, Laurie L.; Delmeire, Dominique; Hinke, Simon A.; Yamada, Yuichiro; Tsukiyama, Katsushi; Seino, Yutaka; Holst, Jens J.; Schuit, Frans; Drucker, D.J. (Diabetes (New York, N.Y.), 2004)
Keywords: Animals; Associated diseases and complications; Biological and medical sciences; Care and treatment; Dextrose; Diabetes; Diabetes. Impaired glucose tolerance; Dipeptidyl Peptidase 4 - drug effects; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Enzyme Inhibitors - pharmacology; Exenatide; Glucagon; Glucagon-Like Peptide-1 Receptor; Glucose; Glucose - metabolism; Health aspects; Homeostasis; House mouse; Insulin; Insulin - metabolism; Insulin Secretion; Intestines - physiology; Islets of Langerhans - physiology; Medical sciences; Mice; Mice as laboratory animals; Mice, Inbred C57BL; Mice, Knockout; Organic Chemicals - pharmacology; Pancreatic beta cells; Peptides; Peptides - pharmacology; Plasma; Pyrroles - pharmacology; Receptors, Gastrointestinal Hormone - agonists; Receptors, Gastrointestinal Hormone - deficiency; Receptors, Gastrointestinal Hormone - physiology; Receptors, Glucagon - agonists; Receptors, Glucagon - deficiency; Receptors, Glucagon - physiology; Type 2 diabetes; Valine - pharmacology; Venoms - pharmacology; United States; Endocrinopathy; Vertebrata; Mammalia; Mouse; Enteroinsular axis; Animal; Diabetes mellitus; Rodentia; Mutation