The Drosophila vesicular monoamine transporter reduces pesticide-induced loss of dopaminergic neurons

• Published in: Neurobiology of disease Vol. 40; no. 1; pp. 102 - 112
• Main Authors: Lawal, Hakeem O., Chang, Hui-Yun, Terrell, Ashley N., Brooks, Elizabeth S., Pulido, Dianne, Simon, Anne F., Krantz, David E.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2010; Elsevier
• Subjects: Animals; Cell Death - drug effects; Cell Death - physiology; Cell Survival - drug effects; Cell Survival - physiology; Disease Models, Animal; Dopamine; Dopamine - physiology; Down-Regulation - drug effects; Down-Regulation - physiology; Drosophila; Drosophila melanogaster - drug effects; Drosophila melanogaster - physiology; Growth Substances - genetics; Growth Substances - physiology; Neural Inhibition - drug effects; Neural Inhibition - physiology; Neurology; Neurons - drug effects; Neurons - metabolism; Neurons - pathology; Parkinson's disease; Pesticides - antagonists & inhibitors; Pesticides - toxicity; Vesicular Monoamine Transport Proteins - physiology; Vesicular transporter; VMAT; VMAT; Dopamine; Parkinson's disease; Vesicular transporter; Drosophila

Dopamine is cytotoxic and may play a role in the development of Parkinson's disease. However, its interaction with environmental risk factors such as pesticides remains poorly understood. The vesicular monoamine transporter (VMAT) regulates intracellular dopamine content, and we have tested the...