Analysis of the UCHL1 genetic variant in Parkinson's disease among Chinese

The inverse association of the functional ubiquitin carboxy-terminal hydrolase L1 ( UCHL1) S18Y variant with Parkinson's disease (PD) among Caucasian populations has been debated. We conducted a large-scale analysis to investigate the age-of-onset effect of the UCHL1 variant in PD among ethnic...

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Published in	Neurobiology of aging Vol. 31; no. 12; pp. 2194 - 2196
Main Authors	Tan, E.K., Lu, C.S., Peng, R., Teo, Y.Y., Wu-Chou, Y.H., Chen, R.S., Weng, Y.H., Chen, C.M., Fung, H.C., Tan, L.C., Zhang, Z.J., An, X.K., Lee-Chen, G.J., Lee, M.C., Fook-Chong, S., Burgunder, J.M., Wu, R.M., Wu, Y.R.
Format	Journal Article
Language	English
Published	United States Elsevier Inc 01.12.2010
Subjects	Adolescent Adult Age of Onset Aged Aged, 80 and over Asian Continental Ancestry Group - ethnology Asian Continental Ancestry Group - genetics Female Genetic Association Studies Genetic Variation - genetics Humans Internal Medicine Male Middle Aged Neurology Parkinson Disease - enzymology Parkinson Disease - epidemiology Parkinson Disease - genetics Parkinson's disease Polymorphism Singapore - epidemiology Singapore - ethnology Taiwan - epidemiology Taiwan - ethnology Ubiquitin Thiolesterase - genetics Ubiquitination - genetics UCHL1 Young Adult Singapore Taiwan UCHL1 Parkinson's disease Polymorphism
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Abstract	The inverse association of the functional ubiquitin carboxy-terminal hydrolase L1 ( UCHL1) S18Y variant with Parkinson's disease (PD) among Caucasian populations has been debated. We conducted a large-scale analysis to investigate the age-of-onset effect of the UCHL1 variant in PD among ethnic Chinese. Individual data sets from 5 centers comprising a total of 4088 study subjects were analyzed. In the univariate analysis, only data from 1 center showed a trend towards a protective effect among young subjects. However, in the combined analysis, no significant association between the UCHL1 variant and PD was detected (A allele frequency 0.531 vs. 0.528, p = 0.87, OR 1.01, 95% CI 0.92–1.1). Among subjects less than 60 years old, the OR is 0.99 (95% CI 0.84–1.16, p = 0.88). A multivariate logistic regression analysis showed that family history, UCHL1 variant and the interaction of UCHL1 variant and age at onset ( p = 0.816) were not significantly associated with PD.
AbstractList	The inverse association of the functional ubiquitin carboxy-terminal hydrolase L1 ( UCHL1) S18Y variant with Parkinson's disease (PD) among Caucasian populations has been debated. We conducted a large-scale analysis to investigate the age-of-onset effect of the UCHL1 variant in PD among ethnic Chinese. Individual data sets from 5 centers comprising a total of 4088 study subjects were analyzed. In the univariate analysis, only data from 1 center showed a trend towards a protective effect among young subjects. However, in the combined analysis, no significant association between the UCHL1 variant and PD was detected (A allele frequency 0.531 vs. 0.528, p = 0.87, OR 1.01, 95% CI 0.92–1.1). Among subjects less than 60 years old, the OR is 0.99 (95% CI 0.84–1.16, p = 0.88). A multivariate logistic regression analysis showed that family history, UCHL1 variant and the interaction of UCHL1 variant and age at onset ( p = 0.816) were not significantly associated with PD. The inverse association of the functional ubiquitin carboxy-terminal hydrolase L1 (UCHL1) S18Y variant with Parkinson's disease (PD) among Caucasian populations has been debated. We conducted a large-scale analysis to investigate the age-of-onset effect of the UCHL1 variant in PD among ethnic Chinese. Individual data sets from 5 centers comprising a total of 4088 study subjects were analyzed. In the univariate analysis, only data from 1 center showed a trend towards a protective effect among young subjects. However, in the combined analysis, no significant association between the UCHL1 variant and PD was detected (A allele frequency 0.531 vs. 0.528, p = 0.87, OR 1.01, 95% CI 0.92-1.1). Among subjects less than 60 years old, the OR is 0.99 (95% CI 0.84-1.16, p = 0.88). A multivariate logistic regression analysis showed that family history, UCHL1 variant and the interaction of UCHL1 variant and age at onset (p = 0.816) were not significantly associated with PD. Abstract The inverse association of the functional ubiquitin carboxy-terminal hydrolase L1 ( UCHL1 ) S18Y variant with Parkinson's disease (PD) among Caucasian populations has been debated. We conducted a large-scale analysis to investigate the age-of-onset effect of the UCHL1 variant in PD among ethnic Chinese. Individual data sets from 5 centers comprising a total of 4088 study subjects were analyzed. In the univariate analysis, only data from 1 center showed a trend towards a protective effect among young subjects. However, in the combined analysis, no significant association between the UCHL1 variant and PD was detected (A allele frequency 0.531 vs. 0.528, p = 0.87, OR 1.01, 95% CI 0.92–1.1). Among subjects less than 60 years old, the OR is 0.99 (95% CI 0.84–1.16, p = 0.88). A multivariate logistic regression analysis showed that family history, UCHL1 variant and the interaction of UCHL1 variant and age at onset ( p = 0.816) were not significantly associated with PD. The inverse association of the functional ubiquitin carboxy-terminal hydrolase L1 (UCHL1) S18Y variant with Parkinson's disease (PD) among Caucasian populations has been debated. We conducted a large-scale analysis to investigate the age-of-onset effect of the UCHL1 variant in PD among ethnic Chinese. Individual data sets from 5 centers comprising a total of 4088 study subjects were analyzed. In the univariate analysis, only data from 1 center showed a trend towards a protective effect among young subjects. However, in the combined analysis, no significant association between the UCHL1 variant and PD was detected (A allele frequency 0.531 vs. 0.528, p=0.87, OR 1.01, 95% CI 0.92-1.1). Among subjects less than 60 years old, the OR is 0.99 (95% CI 0.84-1.16, p=0.88). A multivariate logistic regression analysis showed that family history, UCHL1 variant and the interaction of UCHL1 variant and age at onset (p=0.816) were not significantly associated with PD.The inverse association of the functional ubiquitin carboxy-terminal hydrolase L1 (UCHL1) S18Y variant with Parkinson's disease (PD) among Caucasian populations has been debated. We conducted a large-scale analysis to investigate the age-of-onset effect of the UCHL1 variant in PD among ethnic Chinese. Individual data sets from 5 centers comprising a total of 4088 study subjects were analyzed. In the univariate analysis, only data from 1 center showed a trend towards a protective effect among young subjects. However, in the combined analysis, no significant association between the UCHL1 variant and PD was detected (A allele frequency 0.531 vs. 0.528, p=0.87, OR 1.01, 95% CI 0.92-1.1). Among subjects less than 60 years old, the OR is 0.99 (95% CI 0.84-1.16, p=0.88). A multivariate logistic regression analysis showed that family history, UCHL1 variant and the interaction of UCHL1 variant and age at onset (p=0.816) were not significantly associated with PD.
Author	An, X.K. Burgunder, J.M. Wu, Y.R. Wu-Chou, Y.H. Lu, C.S. Tan, E.K. Tan, L.C. Fook-Chong, S. Weng, Y.H. Chen, C.M. Chen, R.S. Wu, R.M. Lee, M.C. Fung, H.C. Peng, R. Zhang, Z.J. Lee-Chen, G.J. Teo, Y.Y.
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Snippet	The inverse association of the functional ubiquitin carboxy-terminal hydrolase L1 ( UCHL1) S18Y variant with Parkinson's disease (PD) among Caucasian... Abstract The inverse association of the functional ubiquitin carboxy-terminal hydrolase L1 ( UCHL1 ) S18Y variant with Parkinson's disease (PD) among Caucasian... The inverse association of the functional ubiquitin carboxy-terminal hydrolase L1 (UCHL1) S18Y variant with Parkinson's disease (PD) among Caucasian...
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SubjectTerms	Adolescent Adult Age of Onset Aged Aged, 80 and over Asian Continental Ancestry Group - ethnology Asian Continental Ancestry Group - genetics Female Genetic Association Studies Genetic Variation - genetics Humans Internal Medicine Male Middle Aged Neurology Parkinson Disease - enzymology Parkinson Disease - epidemiology Parkinson Disease - genetics Parkinson's disease Polymorphism Singapore - epidemiology Singapore - ethnology Taiwan - epidemiology Taiwan - ethnology Ubiquitin Thiolesterase - genetics Ubiquitination - genetics UCHL1 Young Adult
Title	Analysis of the UCHL1 genetic variant in Parkinson's disease among Chinese
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