Analysis of the UCHL1 genetic variant in Parkinson's disease among Chinese

• Published in: Neurobiology of aging Vol. 31; no. 12; pp. 2194 - 2196
• Main Authors: Tan, E.K., Lu, C.S., Peng, R., Teo, Y.Y., Wu-Chou, Y.H., Chen, R.S., Weng, Y.H., Chen, C.M., Fung, H.C., Tan, L.C., Zhang, Z.J., An, X.K., Lee-Chen, G.J., Lee, M.C., Fook-Chong, S., Burgunder, J.M., Wu, R.M., Wu, Y.R.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2010
• Subjects: Adolescent; Adult; Age of Onset; Aged; Aged, 80 and over; Asian Continental Ancestry Group - ethnology; Asian Continental Ancestry Group - genetics; Female; Genetic Association Studies; Genetic Variation - genetics; Humans; Internal Medicine; Male; Middle Aged; Neurology; Parkinson Disease - enzymology; Parkinson Disease - epidemiology; Parkinson Disease - genetics; Parkinson's disease; Polymorphism; Singapore - epidemiology; Singapore - ethnology; Taiwan - epidemiology; Taiwan - ethnology; Ubiquitin Thiolesterase - genetics; Ubiquitination - genetics; UCHL1; Young Adult; Singapore; Taiwan; UCHL1; Parkinson's disease; Polymorphism
• ISSN: 0197-4580; 1558-1497; 1558-1497
• DOI: 10.1016/j.neurobiolaging.2008.11.008

The inverse association of the functional ubiquitin carboxy-terminal hydrolase L1 ( UCHL1) S18Y variant with Parkinson's disease (PD) among Caucasian populations has been debated. We conducted a large-scale analysis to investigate the age-of-onset effect of the UCHL1 variant in PD among ethnic Chinese. Individual data sets from 5 centers comprising a total of 4088 study subjects were analyzed. In the univariate analysis, only data from 1 center showed a trend towards a protective effect among young subjects. However, in the combined analysis, no significant association between the UCHL1 variant and PD was detected (A allele frequency 0.531 vs. 0.528, p = 0.87, OR 1.01, 95% CI 0.92–1.1). Among subjects less than 60 years old, the OR is 0.99 (95% CI 0.84–1.16, p = 0.88). A multivariate logistic regression analysis showed that family history, UCHL1 variant and the interaction of UCHL1 variant and age at onset ( p = 0.816) were not significantly associated with PD.