Cerebral cortex structure in prodromal Huntington disease

• Published in: Neurobiology of disease Vol. 40; no. 3; pp. 544 - 554
• Main Authors: Nopoulos, Peggy C., Aylward, Elizabeth H., Ross, Christopher A., Johnson, Hans J., Magnotta, Vincent A., Juhl, Andrew R., Pierson, Ronald K., Mills, James, Langbehn, Douglas R., Paulsen, Jane S.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2010; Elsevier
• Subjects: Adult; Cerebral cortex; Cerebral Cortex - pathology; Cortical thickness; Early Diagnosis; Female; Humans; Huntington disease; Huntington Disease - genetics; Huntington Disease - pathology; Longitudinal Studies; Magnetic Resonance Imaging; Male; Middle Aged; MRI; Neurology; Surface area; Cerebral cortex; Cortical thickness; Surface area; MRI; Huntington disease

Neuroimaging studies of subjects who are gene-expanded for Huntington Disease, but not yet diagnosed (termed prodromal HD), report that the cortex is “spared,” despite the decrement in striatal and cerebral white-matter volume. Measurement of whole-cortex volume can mask more subtle, but potentially...