The small molecule indirubin-3′-oxime activates Wnt/β-catenin signaling and inhibits adipocyte differentiation and obesity

• Published in: International Journal of Obesity Vol. 38; no. 8; pp. 1044 - 1052
• Main Authors: Choi, O M, Cho, Y-H, Choi, S, Lee, S-H, Seo, S H, Kim, H-Y, Han, G, Min, D S, Park, T, Choi, K Y
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.08.2014; Nature Publishing Group
• Subjects: 3T3-L1 Cells - drug effects; 631/80/86; 692/699/2743/393; 692/700/565/1436; Adipocytes - drug effects; Adipocytes - metabolism; Adipogenesis - drug effects; Animals; Anti-Obesity Agents - pharmacology; Biological and medical sciences; Care and treatment; Cell Differentiation - drug effects; Cell proliferation; Cellular signal transduction; Diet, High-Fat; Epidemiology; Fat cells; Gene expression; Health Promotion and Disease Prevention; Indoles - pharmacology; Internal Medicine; Male; Medical sciences; Medicine; Medicine & Public Health; Medicine, Chinese Traditional; Metabolic Diseases; Metabolic Syndrome - drug therapy; Metabolic Syndrome - metabolism; Mice; Obesity; Obesity - drug therapy; Obesity - metabolism; Original; original-article; Oximes - pharmacology; Physiological aspects; Polymerase Chain Reaction - methods; Public Health; Weight reducing preparations; Wnt Signaling Pathway - drug effects; Wnt/β-catenin pathway; anti-obesity drug; indirubin-3′-oxime; high-fat diet; Drug; Adipocyte; Obesity; Nutrition; Nutrition disorder; Metabolic diseases; Feeding; Anti-obesity agent; Diet; indirubin-3'-oxime; β Catenin; Fat; Small molecule; Differentiation; Nutritional status

Objectives: Activation of the Wnt/β-catenin signaling pathway inhibits adipogenesis by maintaining preadipocytes in an undifferentiated state. We investigated the effect of indirubin-3′-oxime (I3O), which was screened as an activator of the Wnt/β-catenin signaling, on inhibiting the preadipocyte dif...