Effects of hyperprolactinemia on toxicological parameters and proliferation of islet cells in male rats

• Published in: Journal of toxicological sciences Vol. 34; no. 2; pp. 151 - 162
• Main Authors: Ose, Keiko, Miyata, Kaori, Yoshioka, Kaoru, Okuno, Yasuyoshi
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Society of Toxicology 01.04.2009; Japan Science and Technology Agency
• Subjects: Adrenal Glands - metabolism; Adrenal Glands - pathology; Animals; Biological parameters; Blood Chemical Analysis; Body Weight; Bromodeoxyuridine - metabolism; Cell Proliferation; Cholinesterases - blood; Eating; Female; Hematologic Tests; Hhyperprolactinemia; Hyperprolactinemia - metabolism; Hyperprolactinemia - pathology; Hyperprolactinemia - physiopathology; In vivo; Insulin-Secreting Cells - cytology; Insulin-Secreting Cells - physiology; Islet cell; Male; Mammary Glands, Animal - metabolism; Mammary Glands, Animal - pathology; Organ Size; Pituitary Gland - metabolism; Pituitary Gland - transplantation; Pituitary graft; Prolactin - blood; Rats; Rats, Inbred F344

Prolactin has a wide variety of biological effects. Consequences of hyperprolactinemia on islet B cell proliferation as well as general toxicological parameters were here examined using anterior pituitary-grafted rats. Three or six anterior pituitary glands were implanted under single renal capsules...