Natural diterpenes from coffee, cafestol and kahweol induce apoptosis through regulation of specificity protein 1 expression in human malignant pleural mesothelioma

Malignant pleural mesothelioma (MPM) is a highly aggressive cancer with a very poor prognosis. Several clinical studies such as immunotherapy, gene therapy and molecular targeting agents have been tried for treatment of malignant mesothelioma, however, there is no application for effective clinical...

Full description

Saved in:
Bibliographic Details
Published inJournal of biomedical science Vol. 19; no. 1; p. 60
Main Authors Lee, Kyung-Ae, Chae, Jung-Il, Shim, Jung-Hyun
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 26.06.2012
BioMed Central
BMC
Subjects
Analysis
Apoptosis
Apoptosis - drug effects
Biomarkers, Tumor - genetics
Biomarkers, Tumor - metabolism
Cafestol
Cancer
Cancer therapies
Cell Survival - drug effects
Coffee
Diterpenes - administration & dosage
Gene Expression Regulation, Neoplastic - drug effects
Genetic research
Health aspects
Human malignant pleural mesothelioma
Humans
Immunotherapy
Kahweol
Lung Neoplasms - metabolism
Medical research
Mesothelioma - metabolism
Oncology, Experimental
Proteins
Receptors, Immunologic - genetics
Receptors, Immunologic - metabolism
Sp1
Missouri
California
South Korea
Online AccessGet full text

Cover

Abstract Malignant pleural mesothelioma (MPM) is a highly aggressive cancer with a very poor prognosis. Several clinical studies such as immunotherapy, gene therapy and molecular targeting agents have been tried for treatment of malignant mesothelioma, however, there is no application for effective clinical treatment. Coffee has various biological functions such as anti-oxidant, anti-inflammatory, anti-mutagenic and anti-carcinogenic activities. The therapeutic activities of the bioactive compounds in coffee was sugested to influence intracellular signaling of MPM. Regarding to the cancer-related functions, In this study, suppression of Sp1 protein level followed by induction of MSTO-211H cell apoptosis by cafestol and kahweol were investigated in oreder to determine Sp1's potential as a significant target for human MPM therapy as well. Cells were treated separately with final concentration of cafestol and kahweol and the results were analyzed by MTS assay, DAPI staining, PI staining, luciferase assay, RT-PCR, and immunoblotting. Viability of MSTO-211H and H28 cells were decreased, and apoptotic cell death was increased in MSTO-211H as a result of cafestol and kahweol treatment. Cafestol and kahweol increased Sub-G1 population and nuclear condensation in MSTO-211H cells. Roles of Sp1 in cell proliferation and apoptosis of the MSTO-211H cells by the Sp1 inhibitor of Mithramycin A were previously confirmed. Cafestol and kahweol significantly suppressed Sp1 protein levels. Kahweol slightly attenuated Sp1 mRNA, while Cafestol did not affect in MSTO-211H cells. Cafestol and kahweol modulated the promoter activity and protein expression level of the Sp1 regulatory genes including Cyclin D1, Mcl-1, and Survivin in mesothelioma cells. Apoptosis signaling cascade was activated by cleavages of Bid, Caspase-3, and PARP with cafestol and by upregulation of Bax, and downregulation of Bcl-xl by kahweol. Sp1 can be a novel molecular target of cafestol and kahweol in human MPM.
AbstractList Background Malignant pleural mesothelioma (MPM) is a highly aggressive cancer with a very poor prognosis. Several clinical studies such as immunotherapy, gene therapy and molecular targeting agents have been tried for treatment of malignant mesothelioma, however, there is no application for effective clinical treatment. Coffee has various biological functions such as anti-oxidant, anti-inflammatory, anti-mutagenic and anti-carcinogenic activities. The therapeutic activities of the bioactive compounds in coffee was sugested to influence intracellular signaling of MPM. Regarding to the cancer-related functions, In this study, suppression of Sp1 protein level followed by induction of MSTO-211H cell apoptosis by cafestol and kahweol were investigated in oreder to determine Sp1's potential as a significant target for human MPM therapy as well. Methods Cells were treated separately with final concentration of cafestol and kahweol and the results were analyzed by MTS assay, DAPI staining, PI staining, luciferase assay, RT-PCR, and immunoblotting. Results Viability of MSTO-211H and H28 cells were decreased, and apoptotic cell death was increased in MSTO-211H as a result of cafestol and kahweol treatment. Cafestol and kahweol increased Sub-G.sub.1 population and nuclear condensation in MSTO-211H cells. Roles of Sp1 in cell proliferation and apoptosis of the MSTO-211H cells by the Sp1 inhibitor of Mithramycin A were previously confirmed. Cafestol and kahweol significantly suppressed Sp1 protein levels. Kahweol slightly attenuated Sp1 mRNA, while Cafestol did not affect in MSTO-211H cells. Cafestol and kahweol modulated the promoter activity and protein expression level of the Sp1 regulatory genes including Cyclin D1, Mcl-1, and Survivin in mesothelioma cells. Apoptosis signaling cascade was activated by cleavages of Bid, Caspase-3, and PARP with cafestol and by upregulation of Bax, and downregulation of Bcl-.sub.xl by kahweol. Conclusions Sp1 can be a novel molecular target of cafestol and kahweol in human MPM. Keywords: Coffee, Cafestol, Kahweol, Apoptosis, Sp1, Human malignant pleural mesothelioma
Background: Malignant pleural mesothelioma (MPM) is a highly aggressive cancer with a very poor prognosis. Several clinical studies such as immunotherapy, gene therapy and molecular targeting agents have been tried for treatment of malignant mesothelioma, however, there is no application for effective clinical treatment. Coffee has various biological functions such as anti-oxidant, anti-inflammatory, anti-mutagenic and anti-carcinogenic activities. The therapeutic activities of the bioactive compounds in coffee was sugested to influence intracellular signaling of MPM. Regarding to the cancer-related functions, In this study, suppression of Sp1 protein level followed by induction of MSTO-211H cell apoptosis by cafestol and kahweol were investigated in oreder to determine Sp1's potential as a significant target for human MPM therapy as well. Methods: Cells were treated separately with final concentration of cafestol and kahweol and the results were analyzed by MTS assay, DAPI staining, PI staining, luciferase assay, RT-PCR, and immunoblotting. Results: Viability of MSTO-211H and H28 cells were decreased, and apoptotic cell death was increased in MSTO-211H as a result of cafestol and kahweol treatment. Cafestol and kahweol increased Sub-G sub(1) population and nuclear condensation in MSTO-211H cells. Roles of Sp1 in cell proliferation and apoptosis of the MSTO-211H cells by the Sp1 inhibitor of Mithramycin A were previously confirmed. Cafestol and kahweol significantly suppressed Sp1 protein levels. Kahweol slightly attenuated Sp1 mRNA, while Cafestol did not affect in MSTO-211H cells. Cafestol and kahweol modulated the promoter activity and protein expression level of the Sp1 regulatory genes including Cyclin D1, Mcl-1, and Survivin in mesothelioma cells. Apoptosis signaling cascade was activated by cleavages of Bid, Caspase-3, and PARP with cafestol and by upregulation of Bax, and downregulation of Bcl- sub(xl) by kahweol. Conclusions: Sp1 can be a novel molecular target of cafestol and kahweol in human MPM.
Malignant pleural mesothelioma (MPM) is a highly aggressive cancer with a very poor prognosis. Several clinical studies such as immunotherapy, gene therapy and molecular targeting agents have been tried for treatment of malignant mesothelioma, however, there is no application for effective clinical treatment. Coffee has various biological functions such as anti-oxidant, anti-inflammatory, anti-mutagenic and anti-carcinogenic activities. The therapeutic activities of the bioactive compounds in coffee was sugested to influence intracellular signaling of MPM. Regarding to the cancer-related functions, In this study, suppression of Sp1 protein level followed by induction of MSTO-211H cell apoptosis by cafestol and kahweol were investigated in oreder to determine Sp1's potential as a significant target for human MPM therapy as well. Cells were treated separately with final concentration of cafestol and kahweol and the results were analyzed by MTS assay, DAPI staining, PI staining, luciferase assay, RT-PCR, and immunoblotting. Viability of MSTO-211H and H28 cells were decreased, and apoptotic cell death was increased in MSTO-211H as a result of cafestol and kahweol treatment. Cafestol and kahweol increased Sub-G.sub.1 population and nuclear condensation in MSTO-211H cells. Roles of Sp1 in cell proliferation and apoptosis of the MSTO-211H cells by the Sp1 inhibitor of Mithramycin A were previously confirmed. Cafestol and kahweol significantly suppressed Sp1 protein levels. Kahweol slightly attenuated Sp1 mRNA, while Cafestol did not affect in MSTO-211H cells. Cafestol and kahweol modulated the promoter activity and protein expression level of the Sp1 regulatory genes including Cyclin D1, Mcl-1, and Survivin in mesothelioma cells. Apoptosis signaling cascade was activated by cleavages of Bid, Caspase-3, and PARP with cafestol and by upregulation of Bax, and downregulation of Bcl-.sub.xl by kahweol. Sp1 can be a novel molecular target of cafestol and kahweol in human MPM.
Malignant pleural mesothelioma (MPM) is a highly aggressive cancer with a very poor prognosis. Several clinical studies such as immunotherapy, gene therapy and molecular targeting agents have been tried for treatment of malignant mesothelioma, however, there is no application for effective clinical treatment. Coffee has various biological functions such as anti-oxidant, anti-inflammatory, anti-mutagenic and anti-carcinogenic activities. The therapeutic activities of the bioactive compounds in coffee was sugested to influence intracellular signaling of MPM. Regarding to the cancer-related functions, In this study, suppression of Sp1 protein level followed by induction of MSTO-211H cell apoptosis by cafestol and kahweol were investigated in oreder to determine Sp1's potential as a significant target for human MPM therapy as well. Cells were treated separately with final concentration of cafestol and kahweol and the results were analyzed by MTS assay, DAPI staining, PI staining, luciferase assay, RT-PCR, and immunoblotting. Viability of MSTO-211H and H28 cells were decreased, and apoptotic cell death was increased in MSTO-211H as a result of cafestol and kahweol treatment. Cafestol and kahweol increased Sub-G1 population and nuclear condensation in MSTO-211H cells. Roles of Sp1 in cell proliferation and apoptosis of the MSTO-211H cells by the Sp1 inhibitor of Mithramycin A were previously confirmed. Cafestol and kahweol significantly suppressed Sp1 protein levels. Kahweol slightly attenuated Sp1 mRNA, while Cafestol did not affect in MSTO-211H cells. Cafestol and kahweol modulated the promoter activity and protein expression level of the Sp1 regulatory genes including Cyclin D1, Mcl-1, and Survivin in mesothelioma cells. Apoptosis signaling cascade was activated by cleavages of Bid, Caspase-3, and PARP with cafestol and by upregulation of Bax, and downregulation of Bcl-xl by kahweol. Sp1 can be a novel molecular target of cafestol and kahweol in human MPM.
Abstract Background Malignant pleural mesothelioma (MPM) is a highly aggressive cancer with a very poor prognosis. Several clinical studies such as immunotherapy, gene therapy and molecular targeting agents have been tried for treatment of malignant mesothelioma, however, there is no application for effective clinical treatment. Coffee has various biological functions such as anti-oxidant, anti-inflammatory, anti-mutagenic and anti-carcinogenic activities. The therapeutic activities of the bioactive compounds in coffee was sugested to influence intracellular signaling of MPM. Regarding to the cancer-related functions, In this study, suppression of Sp1 protein level followed by induction of MSTO-211H cell apoptosis by cafestol and kahweol were investigated in oreder to determine Sp1's potential as a significant target for human MPM therapy as well. Methods Cells were treated separately with final concentration of cafestol and kahweol and the results were analyzed by MTS assay, DAPI staining, PI staining, luciferase assay, RT-PCR, and immunoblotting. Results Viability of MSTO-211H and H28 cells were decreased, and apoptotic cell death was increased in MSTO-211H as a result of cafestol and kahweol treatment. Cafestol and kahweol increased Sub-G1 population and nuclear condensation in MSTO-211H cells. Roles of Sp1 in cell proliferation and apoptosis of the MSTO-211H cells by the Sp1 inhibitor of Mithramycin A were previously confirmed. Cafestol and kahweol significantly suppressed Sp1 protein levels. Kahweol slightly attenuated Sp1 mRNA, while Cafestol did not affect in MSTO-211H cells. Cafestol and kahweol modulated the promoter activity and protein expression level of the Sp1 regulatory genes including Cyclin D1, Mcl-1, and Survivin in mesothelioma cells. Apoptosis signaling cascade was activated by cleavages of Bid, Caspase-3, and PARP with cafestol and by upregulation of Bax, and downregulation of Bcl-xl by kahweol. Conclusions Sp1 can be a novel molecular target of cafestol and kahweol in human MPM.
Abstract Background Malignant pleural mesothelioma (MPM) is a highly aggressive cancer with a very poor prognosis. Several clinical studies such as immunotherapy, gene therapy and molecular targeting agents have been tried for treatment of malignant mesothelioma, however, there is no application for effective clinical treatment. Coffee has various biological functions such as anti-oxidant, anti-inflammatory, anti-mutagenic and anti-carcinogenic activities. The therapeutic activities of the bioactive compounds in coffee was sugested to influence intracellular signaling of MPM. Regarding to the cancer-related functions, In this study, suppression of Sp1 protein level followed by induction of MSTO-211H cell apoptosis by cafestol and kahweol were investigated in oreder to determine Sp1's potential as a significant target for human MPM therapy as well. Methods Cells were treated separately with final concentration of cafestol and kahweol and the results were analyzed by MTS assay, DAPI staining, PI staining, luciferase assay, RT-PCR, and immunoblotting. Results Viability of MSTO-211H and H28 cells were decreased, and apoptotic cell death was increased in MSTO-211H as a result of cafestol and kahweol treatment. Cafestol and kahweol increased Sub-G 1 population and nuclear condensation in MSTO-211H cells. Roles of Sp1 in cell proliferation and apoptosis of the MSTO-211H cells by the Sp1 inhibitor of Mithramycin A were previously confirmed. Cafestol and kahweol significantly suppressed Sp1 protein levels. Kahweol slightly attenuated Sp1 mRNA, while Cafestol did not affect in MSTO-211H cells. Cafestol and kahweol modulated the promoter activity and protein expression level of the Sp1 regulatory genes including Cyclin D1, Mcl-1, and Survivin in mesothelioma cells. Apoptosis signaling cascade was activated by cleavages of Bid, Caspase-3, and PARP with cafestol and by upregulation of Bax, and downregulation of Bcl- xl by kahweol. Conclusions Sp1 can be a novel molecular target of cafestol and kahweol in human MPM.
Doc number: 60 Abstract Background: Malignant pleural mesothelioma (MPM) is a highly aggressive cancer with a very poor prognosis. Several clinical studies such as immunotherapy, gene therapy and molecular targeting agents have been tried for treatment of malignant mesothelioma, however, there is no application for effective clinical treatment. Coffee has various biological functions such as anti-oxidant, anti-inflammatory, anti-mutagenic and anti-carcinogenic activities. The therapeutic activities of the bioactive compounds in coffee was sugested to influence intracellular signaling of MPM. Regarding to the cancer-related functions, In this study, suppression of Sp1 protein level followed by induction of MSTO-211H cell apoptosis by cafestol and kahweol were investigated in oreder to determine Sp1's potential as a significant target for human MPM therapy as well. Methods: Cells were treated separately with final concentration of cafestol and kahweol and the results were analyzed by MTS assay, DAPI staining, PI staining, luciferase assay, RT-PCR, and immunoblotting. Results: Viability of MSTO-211H and H28 cells were decreased, and apoptotic cell death was increased in MSTO-211H as a result of cafestol and kahweol treatment. Cafestol and kahweol increased Sub-G1 population and nuclear condensation in MSTO-211H cells. Roles of Sp1 in cell proliferation and apoptosis of the MSTO-211H cells by the Sp1 inhibitor of Mithramycin A were previously confirmed. Cafestol and kahweol significantly suppressed Sp1 protein levels. Kahweol slightly attenuated Sp1 mRNA, while Cafestol did not affect in MSTO-211H cells. Cafestol and kahweol modulated the promoter activity and protein expression level of the Sp1 regulatory genes including Cyclin D1, Mcl-1, and Survivin in mesothelioma cells. Apoptosis signaling cascade was activated by cleavages of Bid, Caspase-3, and PARP with cafestol and by upregulation of Bax, and downregulation of Bcl-xl by kahweol. Conclusions: Sp1 can be a novel molecular target of cafestol and kahweol in human MPM.
ArticleNumber 60
Audience Academic
Author Shim, Jung-Hyun
Chae, Jung-Il
Lee, Kyung-Ae
AuthorAffiliation 1 Department of Biochemistry, College of Medicine, Soonchunhyang University, Ssangyong-dong, Seobuk-gu, Cheonan, Choongnam, 331-090, Republic of Korea
2 Department of Dental Pharmacology, School of Dentistry, Brain Korea 21 Project, Chonbuk National University, Jeonju, 561-756, Republic of Korea
AuthorAffiliation_xml – name: 1 Department of Biochemistry, College of Medicine, Soonchunhyang University, Ssangyong-dong, Seobuk-gu, Cheonan, Choongnam, 331-090, Republic of Korea
– name: 2 Department of Dental Pharmacology, School of Dentistry, Brain Korea 21 Project, Chonbuk National University, Jeonju, 561-756, Republic of Korea
Author_xml – sequence: 1
  givenname: Kyung-Ae
  surname: Lee
  fullname: Lee, Kyung-Ae
  organization: Department of Biochemistry, College of Medicine, Soonchunhyang University, Ssangyong-dong, Seobuk-gu, Cheonan, Choongnam 331-090, Republic of Korea
– sequence: 2
  givenname: Jung-Il
  surname: Chae
  fullname: Chae, Jung-Il
– sequence: 3
  givenname: Jung-Hyun
  surname: Shim
  fullname: Shim, Jung-Hyun
BackLink https://www.ncbi.nlm.nih.gov/pubmed/22734486$$D View this record in MEDLINE/PubMed
BookMark eNptUk2PFCEQ7Zg17oeevRkSLx6cXWhouvtistn4sclGL3omNVDMMHZDC7S6_8cfKjOzjrvGcKAo3ntFFe-0OvLBY1U9Z_ScsU5eMFHzBWV1u2D9QtJH1ckhc3QvPq5OU9pQypq-a59Ux3XdciE6eVL9-gh5jjAQ4zLGCT0mYmMYiQ7WIr4mGiymHAYC3pCvsP6BJXbezBoJTGHKIblE8jqGebUmEVfzANkFT4IlaULtrNMu35IphozOE0bw5xQxpS2mnNfzCJ6MMLiVB5_JNODuPSOmkNc4uDDC0-qxhSHhs7v9rPry7u3nqw-Lm0_vr68ubxZaNjwvaiOpEdoAlbIG4EJqMFz2yyXtOr3shEZue90ANo0wTEKHS6qp1SCpFcbys-p6r2sCbNQU3QjxVgVwapcIcaUgZqcHVLxGCU2zlFT3wjSy72VnbdsYqDukoilab_Za07wc0Wj0ubT1QPThjXdrtQrfFRec1aItAq_uBGL4Npc_UKNLGocBPIY5KSa4oKzt2bbWy3-gmzBHX0alGC0DaDvZtX9RKygNOG9Dqau3ouqy4cUqfb1Dnf8HVZbB0eniPutK_gHhYk_QMaQU0R56ZFRtTaq2NlRbGyrWK0kL48X90Rzwf1zJfwPO6Odb
CitedBy_id crossref_primary_10_1007_s00217_020_03679_6
crossref_primary_10_1038_s41598_021_83461_0
crossref_primary_10_1007_s00394_015_1139_z
crossref_primary_10_1016_j_jand_2021_10_025
crossref_primary_10_1016_j_biomaterials_2015_02_091
crossref_primary_10_1016_j_intimp_2020_106529
crossref_primary_10_1016_j_fct_2016_07_008
crossref_primary_10_1111_febs_13148
crossref_primary_10_1021_ol500623w
crossref_primary_10_4062_biomolther_2016_114
crossref_primary_10_1038_cddis_2014_472
crossref_primary_10_1002_biof_1437
crossref_primary_10_3390_ijms20174238
crossref_primary_10_1016_j_indcrop_2020_112405
crossref_primary_10_1080_10942912_2019_1593193
crossref_primary_10_1080_87559129_2022_2141776
crossref_primary_10_1007_s40257_015_0165_1
crossref_primary_10_1186_s10020_019_0074_5
crossref_primary_10_1093_carcin_bgaa113
crossref_primary_10_3390_plants12081580
crossref_primary_10_1016_j_jnutbio_2015_08_028
crossref_primary_10_4103_pr_pr_66_20
crossref_primary_10_1002_ptr_5669
crossref_primary_10_4062_biomolther_2014_133
crossref_primary_10_1007_s00066_014_0807_x
crossref_primary_10_1016_j_cbi_2019_05_005
crossref_primary_10_18632_oncotarget_4017
crossref_primary_10_3164_jcbn_13_28
crossref_primary_10_7554_eLife_85985
crossref_primary_10_1080_10408398_2017_1369391
crossref_primary_10_1016_j_nfs_2016_02_001
crossref_primary_10_1016_j_lwt_2019_108593
crossref_primary_10_1016_j_lfs_2022_120922
crossref_primary_10_1093_comjnl_bxab146
crossref_primary_10_1093_jnci_dju421
crossref_primary_10_1002_jcb_25573
crossref_primary_10_1016_j_bbrc_2014_04_026
crossref_primary_10_1371_journal_pone_0147056
crossref_primary_10_4103_jdds_jdds_52_19
crossref_primary_10_1016_j_envres_2016_02_038
crossref_primary_10_1002_jccs_201700360
crossref_primary_10_3390_plants12091840
crossref_primary_10_1038_srep07162
crossref_primary_10_1080_01635581_2018_1460681
crossref_primary_10_1016_S2222_1808_16_61140_4
crossref_primary_10_3390_genes14101927
crossref_primary_10_1080_05704928_2023_2295351
crossref_primary_10_1016_j_tetlet_2014_11_035
crossref_primary_10_3390_molecules27217332
crossref_primary_10_1016_j_tifs_2021_06_023
crossref_primary_10_17116_klinderma201918051548
crossref_primary_10_3390_ijerph18157945
crossref_primary_10_1007_s13671_017_0193_6
crossref_primary_10_1016_j_fct_2018_12_038
crossref_primary_10_1016_j_oraloncology_2013_11_006
crossref_primary_10_3892_mmr_2015_3450
crossref_primary_10_1186_s12986_019_0365_4
crossref_primary_10_3390_nu8050275
crossref_primary_10_3390_ijms22158279
crossref_primary_10_1002_ptr_5800
crossref_primary_10_3390_biologics4020014
crossref_primary_10_3892_ijo_2016_3727
crossref_primary_10_1016_j_ejphar_2017_12_030
crossref_primary_10_1016_j_foodchem_2014_05_039
crossref_primary_10_1002_fsn3_3848
Cites_doi 10.1016/S0278-6915(02)00029-7
10.1016/j.taap.2007.09.018
10.1016/j.advenzreg.2007.11.016
10.1016/j.taap.2006.09.013
10.1053/sonc.2002.30227
10.1016/j.ccm.2011.08.006
10.1517/14728210903074563
10.1016/j.mehy.2008.06.026
10.1007/s00280-011-1655-3
10.1080/01635580903407122
10.1016/S0278-6915(96)00123-8
10.1016/j.ejca.2005.08.006
10.1073/pnas.0604008103
10.1038/sj.onc.1209696
10.1371/journal.pone.0007035
10.1124/dmd.105.004069
10.1016/j.toxlet.2009.01.022
10.2217/bmm.11.18
10.1080/10408390903586412
10.1002/mnfr.200400109
10.1002/ijc.24563
10.1016/j.febslet.2004.05.070
10.1080/10408390701522445
10.1111/j.1349-7006.2011.01871.x
10.1056/NEJMra050152
10.2174/157340611796799203
10.1016/j.phrs.2007.01.006
10.1002/jcp.1111
10.1016/j.aanat.2010.07.010
10.1016/j.ctrv.2011.01.001
10.1248/bpb.33.128
10.1016/j.cbi.2010.04.013
10.1111/j.1349-7006.2010.01554.x
10.1021/jf00056a039
10.1007/s00204-002-0322-1
10.1016/j.lungcan.2005.03.009
ContentType Journal Article
Copyright COPYRIGHT 2012 BioMed Central Ltd.
2012 Lee et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright ©2012 Lee et al.; licensee BioMed Central Ltd. 2012 Lee et al.; licensee BioMed Central Ltd.
Copyright_xml – notice: COPYRIGHT 2012 BioMed Central Ltd.
– notice: 2012 Lee et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
– notice: Copyright ©2012 Lee et al.; licensee BioMed Central Ltd. 2012 Lee et al.; licensee BioMed Central Ltd.
DBID CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
3V.
7QL
7QO
7QP
7T5
7TK
7TM
7U7
7U9
7X7
7XB
88E
8FD
8FE
8FG
8FH
8FI
8FJ
8FK
8G5
ABJCF
ABUWG
AFKRA
AZQEC
BBNVY
BENPR
BGLVJ
BHPHI
C1K
CCPQU
DWQXO
FR3
FYUFA
GHDGH
GNUQQ
GUQSH
H94
HCIFZ
K9.
L6V
LK8
M0S
M1P
M2O
M7N
M7P
M7S
MBDVC
P64
PIMPY
PQEST
PQQKQ
PQUKI
PRINS
PTHSS
Q9U
RC3
5PM
DOA
DOI 10.1186/1423-0127-19-60
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
ProQuest Central (Corporate)
Bacteriology Abstracts (Microbiology B)
Biotechnology Research Abstracts
Calcium & Calcified Tissue Abstracts
Immunology Abstracts
Neurosciences Abstracts
Nucleic Acids Abstracts
Toxicology Abstracts
Virology and AIDS Abstracts
Health Medical collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
Technology Research Database
ProQuest SciTech Collection
ProQuest Technology Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
Research Library (Alumni Edition)
Materials Science & Engineering Collection
ProQuest Central (Alumni)
ProQuest Central
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Technology Collection
ProQuest Natural Science Collection
Environmental Sciences and Pollution Management
ProQuest One Community College
ProQuest Central
Engineering Research Database
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
Research Library Prep
AIDS and Cancer Research Abstracts
SciTech Premium Collection (Proquest) (PQ_SDU_P3)
ProQuest Health & Medical Complete (Alumni)
ProQuest Engineering Collection
Biological Sciences
Health & Medical Collection (Alumni Edition)
PML(ProQuest Medical Library)
ProQuest Research Library
Algology Mycology and Protozoology Abstracts (Microbiology C)
Biological Science Database
Engineering Database
Research Library (Corporate)
Biotechnology and BioEngineering Abstracts
Publicly Available Content Database
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
Engineering Collection
ProQuest Central Basic
Genetics Abstracts
PubMed Central (Full Participant titles)
Directory of Open Access Journals (Open Access)
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
Publicly Available Content Database
Research Library Prep
ProQuest Central Student
ProQuest Central Essentials
Nucleic Acids Abstracts
SciTech Premium Collection
ProQuest Central China
Environmental Sciences and Pollution Management
Health Research Premium Collection
Natural Science Collection
Biological Science Collection
ProQuest Medical Library (Alumni)
Engineering Collection
Engineering Database
Virology and AIDS Abstracts
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
ProQuest Technology Collection
Health Research Premium Collection (Alumni)
Biological Science Database
Neurosciences Abstracts
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
Engineering Research Database
ProQuest One Academic
Calcium & Calcified Tissue Abstracts
Technology Collection
Technology Research Database
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
Research Library (Alumni Edition)
ProQuest Natural Science Collection
ProQuest Central
Genetics Abstracts
ProQuest Engineering Collection
Biotechnology Research Abstracts
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Bacteriology Abstracts (Microbiology B)
Algology Mycology and Protozoology Abstracts (Microbiology C)
AIDS and Cancer Research Abstracts
ProQuest Research Library
ProQuest Central Basic
Toxicology Abstracts
ProQuest SciTech Collection
ProQuest Medical Library
Materials Science & Engineering Collection
Immunology Abstracts
ProQuest Central (Alumni)
DatabaseTitleList
Engineering Research Database

MEDLINE

CrossRef
Publicly Available Content Database
Database_xml – sequence: 1
  dbid: DOA
  name: Directory of Open Access Journals (DOAJ)
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 4
  dbid: 8FG
  name: ProQuest Technology Collection
  url: https://search.proquest.com/technologycollection1
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Biology
EISSN 1423-0127
EndPage 60
ExternalDocumentID oai_doaj_org_article_32e6a55b60c94d569968ff75da28e045
2748239651
A534239287
10_1186_1423_0127_19_60
22734486
Genre Research Support, Non-U.S. Gov't
Journal Article
GeographicLocations Missouri
California
South Korea
GeographicLocations_xml – name: Missouri
– name: California
– name: South Korea
GroupedDBID ---
-A0
.86
0R~
29J
29K
2NJ
2VQ
2WC
36B
3V.
4.4
5GY
5VS
7X7
88E
8FE
8FG
8FH
8FI
8FJ
8G5
AAFWJ
AAIAL
AAYZH
ABDBF
ABJCF
ABOCM
ABUWG
ACGFO
ACGFS
ACIHN
ACIWK
ACPRK
ACRMQ
ADBBV
ADIMF
ADINQ
ADRAZ
ADUKV
AEAQA
AEGNC
AENEX
AFGCZ
AFKRA
AFPKN
AFRAH
AHBYD
AHMBA
AHSBF
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AMKLP
AMTXH
AOIJS
AZQEC
B0M
BAPOH
BAWUL
BBNVY
BCNDV
BENPR
BFQNJ
BGLVJ
BGNMA
BHPHI
BMC
BPHCQ
BVXVI
C24
C6C
CCPQU
CGR
CS3
CUY
CVF
CYUIP
D-I
DIK
DU5
DWQXO
E3Z
EAD
EAP
EBC
EBD
EBLON
EBS
ECM
EIF
EJD
EMB
EMK
EMOBN
EPL
ESX
F5P
FYUFA
GNUQQ
GROUPED_DOAJ
GUQSH
GX1
HCIFZ
HMCUK
HYE
IAO
IEA
IHE
IHR
INH
INR
IPNFZ
ITC
IZQ
KDC
KQ8
L6V
LAK
LK8
M1P
M2O
M48
M4Y
M7P
M7S
ML~
M~E
NPM
NU0
O5R
O5S
OK1
P19
P2P
PGMZT
PIMPY
PQQKQ
PROAC
PSQYO
PTHSS
RBZ
RHV
RIG
RNS
ROL
RPM
RPX
RRX
RSV
S27
SBL
SDH
SOJ
SV3
T13
TR2
TUS
UKHRP
VC2
WJK
WK8
~8M
~KM
AAYXX
CITATION
AFGXO
7QL
7QO
7QP
7T5
7TK
7TM
7U7
7U9
7XB
8FD
8FK
C1K
FR3
H94
K9.
M7N
MBDVC
P64
PQEST
PQUKI
PRINS
Q9U
RC3
5PM
ID FETCH-LOGICAL-c653t-2d60d4cda0662aa346cad369bb088cb84ce3f9c5ae554d16a8eb0c0fca60f4df3
IEDL.DBID RPM
ISSN 1423-0127
1021-7770
IngestDate Tue Oct 22 15:12:59 EDT 2024
Tue Sep 17 21:26:47 EDT 2024
Fri Oct 25 09:20:25 EDT 2024
Thu Oct 10 15:56:32 EDT 2024
Wed Aug 14 18:51:32 EDT 2024
Tue Nov 12 23:35:05 EST 2024
Thu Sep 12 18:14:54 EDT 2024
Tue Oct 15 23:44:28 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Language English
License This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c653t-2d60d4cda0662aa346cad369bb088cb84ce3f9c5ae554d16a8eb0c0fca60f4df3
Notes ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431247/
PMID 22734486
PQID 1036978687
PQPubID 54111
PageCount 1
ParticipantIDs doaj_primary_oai_doaj_org_article_32e6a55b60c94d569968ff75da28e045
pubmedcentral_primary_oai_pubmedcentral_nih_gov_3431247
proquest_miscellaneous_1434017915
proquest_journals_1036978687
gale_infotracmisc_A534239287
gale_infotracacademiconefile_A534239287
crossref_primary_10_1186_1423_0127_19_60
pubmed_primary_22734486
PublicationCentury 2000
PublicationDate 2012-06-26
PublicationDateYYYYMMDD 2012-06-26
PublicationDate_xml – month: 06
  year: 2012
  text: 2012-06-26
  day: 26
PublicationDecade 2010
PublicationPlace England
PublicationPlace_xml – name: England
– name: Basel
PublicationTitle Journal of biomedical science
PublicationTitleAlternate J Biomed Sci
PublicationYear 2012
Publisher BioMed Central Ltd
BioMed Central
BMC
Publisher_xml – name: BioMed Central Ltd
– name: BioMed Central
– name: BMC
References 21241418 - Cancer Sci. 2011 Apr;102(4):742-8
22022994 - Med Chem. 2011 Sep;7(5):518-25
17097123 - Toxicol Appl Pharmacol. 2006 Dec 15;217(3):332-41
19429240 - Toxicol Lett. 2009 May 22;187(1):28-34
16798876 - Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10397-402
18028974 - Toxicol Appl Pharmacol. 2008 Feb 1;226(3):328-37
21553148 - Cancer Chemother Pharmacol. 2011 Jul;68(1):1-15
9225012 - Food Chem Toxicol. 1997 Jun;35(6):547-54
21473730 - Biomark Med. 2011 Apr;5(2):261-73
20358464 - Nutr Cancer. 2010;62(3):271-83
17368041 - Pharmacol Res. 2007 Mar;55(3):187-98
19753117 - PLoS One. 2009;4(9):e7035
15894403 - Lung Cancer. 2005 Jul;49 Suppl 1:S49-52
15225655 - FEBS Lett. 2004 Jul 2;569(1-3):321-6
12029384 - Arch Toxicol. 2002 May;76(4):209-17
18701223 - Med Hypotheses. 2008 Nov;71(5):730-6
11424081 - J Cell Physiol. 2001 Aug;188(2):143-60
18464035 - Crit Rev Food Sci Nutr. 2008 May;48(5):464-86
20387253 - Zhejiang Da Xue Xue Bao Yi Xue Ban. 2010 Mar;39(2):215-20
21432699 - Crit Rev Food Sci Nutr. 2011 Apr;51(4):363-73
12067578 - Food Chem Toxicol. 2002 Aug;40(8):1155-63
22054892 - Clin Chest Med. 2011 Dec;32(4):865-85
16715126 - Oncogene. 2006 Nov 9;25(53):7096-105
15704241 - Mol Nutr Food Res. 2005 Mar;49(3):274-84
20384626 - Cancer Sci. 2010 Jun;101(6):1463-70
16209919 - Eur J Cancer. 2005 Nov;41(16):2438-48
21288646 - Cancer Treat Rev. 2011 Nov;37(7):543-58
12414630 - Cancer Res. 2002 Nov 1;62(21):6065-9
19552609 - Expert Opin Emerg Drugs. 2009 Sep;14(3):423-37
18187045 - Adv Enzyme Regul. 2008;48:189-208
16221782 - N Engl J Med. 2005 Oct 13;353(15):1591-603
15860659 - Drug Metab Dispos. 2005 Aug;33(8):1244-53
11836664 - Semin Oncol. 2002 Feb;29(1):2-17
20403343 - Chem Biol Interact. 2010 Jun 7;186(1):36-42
19588484 - Int J Cancer. 2009 Nov 1;125(9):2066-76
20810260 - Ann Anat. 2010 Sep 20;192(5):275-83
20045950 - Biol Pharm Bull. 2010;33(1):128-32
MS Butt (416_CR13) 2011; 51
LM Kong (416_CR19) 2010; 101
E Deniaud (416_CR22) 2009; 4
PA Zucali (416_CR6) 2011; 37
H Yang (416_CR30) 2006; 103
X Bai (416_CR16) 2010; 39
C Cavin (416_CR23) 2002; 40
ME Ramos-Nino (416_CR31) 2002; 62
L Arab (416_CR9) 2010; 62
JN Jakobsen (416_CR28) 2011; 68
AR Black (416_CR35) 2001; 188
A Vachani (416_CR4) 2011; 32
SE George (416_CR7) 2008; 48
JY Kim (416_CR24) 2004; 569
JR Davie (416_CR17) 2008; 48
M Carbone (416_CR3) 2002; 29
WW Huber (416_CR26) 2002; 76
JY Chuang (416_CR18) 2009; 125
HG Kim (416_CR38) 2006; 217
G Gross (416_CR11) 1997; 35
E Deniaud (416_CR36) 2006; 25
A Cristaudo (416_CR2) 2011; 5
HJ Um (416_CR37) 2010; 186
BW Robinson (416_CR1) 2005; 353
T Ranheim (416_CR10) 2005; 49
T Shen (416_CR32) 2010; 33
HG Kim (416_CR34) 2009; 187
C Belli (416_CR5) 2009; 14
JS Bonita (416_CR8) 2007; 55
R Urgert (416_CR12) 1995; 43
ES Choi (416_CR21) 2011; 102
L Li (416_CR14) 2010; 192
J Wan (416_CR15) 2005; 33
UT Sankpal (416_CR20) 2011; 7
LG Higgins (416_CR33) 2008; 226
KS Tao (416_CR25) 2008; 71
JP Steele (416_CR27) 2005; 49
S Safe (416_CR29) 2005; 41
References_xml – volume: 62
  start-page: 6065
  year: 2002
  ident: 416_CR31
  publication-title: Cancer Res
  contributor:
    fullname: ME Ramos-Nino
– volume: 40
  start-page: 1155
  year: 2002
  ident: 416_CR23
  publication-title: Food Chem Toxicol
  doi: 10.1016/S0278-6915(02)00029-7
  contributor:
    fullname: C Cavin
– volume: 226
  start-page: 328
  year: 2008
  ident: 416_CR33
  publication-title: Toxicol Appl Pharmacol
  doi: 10.1016/j.taap.2007.09.018
  contributor:
    fullname: LG Higgins
– volume: 48
  start-page: 189
  year: 2008
  ident: 416_CR17
  publication-title: Adv Enzyme Regul
  doi: 10.1016/j.advenzreg.2007.11.016
  contributor:
    fullname: JR Davie
– volume: 217
  start-page: 332
  year: 2006
  ident: 416_CR38
  publication-title: Toxicol Appl Pharmacol
  doi: 10.1016/j.taap.2006.09.013
  contributor:
    fullname: HG Kim
– volume: 29
  start-page: 2
  year: 2002
  ident: 416_CR3
  publication-title: Semin Oncol
  doi: 10.1053/sonc.2002.30227
  contributor:
    fullname: M Carbone
– volume: 32
  start-page: 865
  year: 2011
  ident: 416_CR4
  publication-title: Clin Chest Med
  doi: 10.1016/j.ccm.2011.08.006
  contributor:
    fullname: A Vachani
– volume: 14
  start-page: 423
  year: 2009
  ident: 416_CR5
  publication-title: Expert Opin Emerg Drugs
  doi: 10.1517/14728210903074563
  contributor:
    fullname: C Belli
– volume: 71
  start-page: 730
  year: 2008
  ident: 416_CR25
  publication-title: Med Hypotheses
  doi: 10.1016/j.mehy.2008.06.026
  contributor:
    fullname: KS Tao
– volume: 68
  start-page: 1
  year: 2011
  ident: 416_CR28
  publication-title: Cancer Chemother Pharmacol
  doi: 10.1007/s00280-011-1655-3
  contributor:
    fullname: JN Jakobsen
– volume: 62
  start-page: 271
  year: 2010
  ident: 416_CR9
  publication-title: Nutr Cancer
  doi: 10.1080/01635580903407122
  contributor:
    fullname: L Arab
– volume: 35
  start-page: 547
  year: 1997
  ident: 416_CR11
  publication-title: Food Chem Toxicol
  doi: 10.1016/S0278-6915(96)00123-8
  contributor:
    fullname: G Gross
– volume: 41
  start-page: 2438
  year: 2005
  ident: 416_CR29
  publication-title: Eur J Cancer
  doi: 10.1016/j.ejca.2005.08.006
  contributor:
    fullname: S Safe
– volume: 103
  start-page: 10397
  year: 2006
  ident: 416_CR30
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.0604008103
  contributor:
    fullname: H Yang
– volume: 25
  start-page: 7096
  year: 2006
  ident: 416_CR36
  publication-title: Oncogene
  doi: 10.1038/sj.onc.1209696
  contributor:
    fullname: E Deniaud
– volume: 4
  start-page: e7035
  year: 2009
  ident: 416_CR22
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0007035
  contributor:
    fullname: E Deniaud
– volume: 33
  start-page: 1244
  year: 2005
  ident: 416_CR15
  publication-title: Drug Metab Dispos
  doi: 10.1124/dmd.105.004069
  contributor:
    fullname: J Wan
– volume: 187
  start-page: 28
  year: 2009
  ident: 416_CR34
  publication-title: Toxicol Lett
  doi: 10.1016/j.toxlet.2009.01.022
  contributor:
    fullname: HG Kim
– volume: 5
  start-page: 261
  year: 2011
  ident: 416_CR2
  publication-title: Biomark Med
  doi: 10.2217/bmm.11.18
  contributor:
    fullname: A Cristaudo
– volume: 51
  start-page: 363
  year: 2011
  ident: 416_CR13
  publication-title: Crit Rev Food Sci Nutr
  doi: 10.1080/10408390903586412
  contributor:
    fullname: MS Butt
– volume: 49
  start-page: 274
  year: 2005
  ident: 416_CR10
  publication-title: Mol Nutr Food Res
  doi: 10.1002/mnfr.200400109
  contributor:
    fullname: T Ranheim
– volume: 125
  start-page: 2066
  year: 2009
  ident: 416_CR18
  publication-title: Int J Cancer
  doi: 10.1002/ijc.24563
  contributor:
    fullname: JY Chuang
– volume: 39
  start-page: 215
  year: 2010
  ident: 416_CR16
  publication-title: Zhejiang Da Xue Xue Bao Yi Xue Ban
  contributor:
    fullname: X Bai
– volume: 569
  start-page: 321
  year: 2004
  ident: 416_CR24
  publication-title: FEBS Lett
  doi: 10.1016/j.febslet.2004.05.070
  contributor:
    fullname: JY Kim
– volume: 48
  start-page: 464
  year: 2008
  ident: 416_CR7
  publication-title: Crit Rev Food Sci Nutr
  doi: 10.1080/10408390701522445
  contributor:
    fullname: SE George
– volume: 102
  start-page: 742
  year: 2011
  ident: 416_CR21
  publication-title: Cancer Sci
  doi: 10.1111/j.1349-7006.2011.01871.x
  contributor:
    fullname: ES Choi
– volume: 353
  start-page: 1591
  year: 2005
  ident: 416_CR1
  publication-title: N Engl J Med
  doi: 10.1056/NEJMra050152
  contributor:
    fullname: BW Robinson
– volume: 7
  start-page: 518
  year: 2011
  ident: 416_CR20
  publication-title: Med Chem
  doi: 10.2174/157340611796799203
  contributor:
    fullname: UT Sankpal
– volume: 55
  start-page: 187
  year: 2007
  ident: 416_CR8
  publication-title: Pharmacol Res
  doi: 10.1016/j.phrs.2007.01.006
  contributor:
    fullname: JS Bonita
– volume: 188
  start-page: 143
  year: 2001
  ident: 416_CR35
  publication-title: J Cell Physiol
  doi: 10.1002/jcp.1111
  contributor:
    fullname: AR Black
– volume: 192
  start-page: 275
  year: 2010
  ident: 416_CR14
  publication-title: Ann Anat
  doi: 10.1016/j.aanat.2010.07.010
  contributor:
    fullname: L Li
– volume: 37
  start-page: 543
  year: 2011
  ident: 416_CR6
  publication-title: Cancer Treat Rev
  doi: 10.1016/j.ctrv.2011.01.001
  contributor:
    fullname: PA Zucali
– volume: 33
  start-page: 128
  year: 2010
  ident: 416_CR32
  publication-title: Biol Pharm Bull
  doi: 10.1248/bpb.33.128
  contributor:
    fullname: T Shen
– volume: 186
  start-page: 36
  year: 2010
  ident: 416_CR37
  publication-title: Chem Biol Interact
  doi: 10.1016/j.cbi.2010.04.013
  contributor:
    fullname: HJ Um
– volume: 101
  start-page: 1463
  year: 2010
  ident: 416_CR19
  publication-title: Cancer Sci
  doi: 10.1111/j.1349-7006.2010.01554.x
  contributor:
    fullname: LM Kong
– volume: 43
  start-page: 2167
  year: 1995
  ident: 416_CR12
  publication-title: J Agric Food Chem
  doi: 10.1021/jf00056a039
  contributor:
    fullname: R Urgert
– volume: 76
  start-page: 209
  year: 2002
  ident: 416_CR26
  publication-title: Arch Toxicol
  doi: 10.1007/s00204-002-0322-1
  contributor:
    fullname: WW Huber
– volume: 49
  start-page: S49
  issue: Suppl 1
  year: 2005
  ident: 416_CR27
  publication-title: Lung Cancer
  doi: 10.1016/j.lungcan.2005.03.009
  contributor:
    fullname: JP Steele
SSID ssj0015987
Score 2.3427548
Snippet Malignant pleural mesothelioma (MPM) is a highly aggressive cancer with a very poor prognosis. Several clinical studies such as immunotherapy, gene therapy and...
Abstract Background Malignant pleural mesothelioma (MPM) is a highly aggressive cancer with a very poor prognosis. Several clinical studies such as...
Background Malignant pleural mesothelioma (MPM) is a highly aggressive cancer with a very poor prognosis. Several clinical studies such as immunotherapy, gene...
Doc number: 60 Abstract Background: Malignant pleural mesothelioma (MPM) is a highly aggressive cancer with a very poor prognosis. Several clinical studies...
Background: Malignant pleural mesothelioma (MPM) is a highly aggressive cancer with a very poor prognosis. Several clinical studies such as immunotherapy, gene...
Abstract Background Malignant pleural mesothelioma (MPM) is a highly aggressive cancer with a very poor prognosis. Several clinical studies such as...
SourceID doaj
pubmedcentral
proquest
gale
crossref
pubmed
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
StartPage 60
SubjectTerms Analysis
Apoptosis
Apoptosis - drug effects
Biomarkers, Tumor - genetics
Biomarkers, Tumor - metabolism
Cafestol
Cancer
Cancer therapies
Cell Survival - drug effects
Coffee
Diterpenes - administration & dosage
Gene Expression Regulation, Neoplastic - drug effects
Genetic research
Health aspects
Human malignant pleural mesothelioma
Humans
Immunotherapy
Kahweol
Lung Neoplasms - metabolism
Medical research
Mesothelioma - metabolism
Oncology, Experimental
Proteins
Receptors, Immunologic - genetics
Receptors, Immunologic - metabolism
Sp1
SummonAdditionalLinks – databaseName: Directory of Open Access Journals (Open Access)
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELZQJRAXBOWVUpCRkOBAVDt-xDkWRFUhtScq9WY5ftAVu8mquxXt_-GHMuNkl404cOESRbETTTzj8Wd55htC3rHQChPrWHITVCkDN2XrPCtD9BWDSwqZ1OfsXJ9eyK-X6nKn1BfGhA30wMPAHYkqaqdUq5lvZFAa8LlJqVbBVSYCHsnelzWbzdR4fqCaXBoP61YDfqzZSOrDjT7iACBKPHAteVNmZso_61Gm7f_bOe-sTtPIyZ2l6OQxeTRiSHo8yP6E3IvdPrk_VJW82ycPzsbz8qfk17nLvBo0YKbxEv0axYQS6vuUYvxIvUtYWmZOXRfoD3f1M8I9bNNB4dQt--W6X81WdCzmQ6-HwvWgStonikmaGGgEOJ5muodZRzmNt2NobQffobkEIF0A2P-OETd0OY9ZnkVcYerXfNYv3DNycfLl2-fTcqzLUHqtxLqsgmZB-uCQPd45IbV3QeimbcFl-dZIH0VqvHIRsErg2pnYMs-Sd5olGZJ4Tva6vosvCQV84bVwKjlvJGesrYJwlWu4B2gYdV2QDxvt2OVAv2HztsVoi4q0qEjLG6tZQT6h9rbdkDc7PwBrsqM12X9ZU0Heo-4tzm5QsHdjkgJIizxZ9lhlxkTYZhbkcNITZqWfNm-sx45eYQWSwyjVRmPz220zvomRbl3sb6CPFBK9JAdZXgzGtv2lCrmIpNEFqSdmOPnnaUs3u8qc4QKAYiXrg_8xSK_IQ4CNFQbMVfqQ7K2vb-JrgGbr9k2ehb8B4w44kA
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: ProQuest Technology Collection
  dbid: 8FG
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Nb9QwELWgCMQFQfkKFGQkJDgQYSeO45xQQSwVUnuiUm-W4492xW4SNlsB_4cfyozXu22ExGUVrZ3I0bPHb-KZN4S8Zq4tla99zpWrcuG4yltjWe68LRj8BBdFfY5P5NGp-HpWnaUPbmMKq9zaxGioXW_xGzms7lKCxyNV_WH4kWPVKDxdTSU0bpJbvKhrdL7U7MvuFKFqYoE8rF4NLLJmSdqHK_meA43I8dg1500e9SmvdqUo3v-vib62R03jJ69tSLP75F5ikvRwA_0DcsN3--T2prbk731y5zidmj8kf05MVNegDvONB7RuFNNKqO1D8P4dtSZggZkFNZ2j383FTw_X4KwD7NQM_bDux_lIU0kfutqUrwdAaR8opmpiuBGweRpFH-Yd5dT_SgG2HTyHxkKAdAmU_xzjbuiw8HE8Sz9iAthi3i_NI3I6-_zt01GeqjPkVlblOi-cZE5YZ1BD3phSSGscYNS2YLhsq4T1ZWhsZTwwFselUb5llgVrJAvChfIx2ev6zj8lFFiGlaWpgrFKcMbawpWmMA23QBC9rDPydouOHjYiHDo6L0pqBFIjkJo3WrKMfET0dt1QPTv-0a_OdVqMuiy8NFXVSmYb4SoJPp8Koa6cKZQHjpuRN4i9xjUOAFuTUhVgtKiWpQ-rqJsIzmZGDiY9YW3aafN29uhkG0Z9NZMz8mrXjHdivFvn-0voI0qBtpLDWJ5sJtvulQpUJBJKZqSeTMPJO09buvlFVA4vgS4Won72_2E9J3eBFhYYEFfIA7K3Xl36F0C91u3LuL7-AjpQMKk
  priority: 102
  providerName: ProQuest
– databaseName: Scholars Portal Open Access Journals
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1LbxMxELZQEYgLgvIKFGQkJDiw4PVrvQeECqKqkNoTkXqzvH60EcluSFLR_h9-KDPOJu2KHrlEUeysvJ6x_Y08832EvGGhESZWsShNUIUMpSka51kRoucMPlLIpD5Hx_pwLL-fqJMrOaB-Apc3hnaoJzVeTD9c_Lr8DAv-U17wRn8sARIUeIValHWhIX6_zSWE6ZjHJ6-uFFSd1fJQyhogZcV6np8bHjA4ojKT_7_79bUDa5hMee10OnhA7vewku6v_eAhuRXbXXJnLTR5uUvuHvVX6I_In2OXqTZowOLjOW51FGtMqO9SivE99S6h2syUujbQn-7sd4TvELmDD1A37-arbjlZ0l7fhy7WWvZgXdolinWbmHsE0J5mBohJS0saL_ps2xaeQ7MqIJ0B_j_FJBw6n8Y8nllcYjXYdNLN3GMyPvj24-th0Us1FF4rsSp40CxIHxwSyjsnpPYuCF03DexivjHSR5Fqr1wE-BJK7UxsmGfJO82SDEk8ITtt18ZnhALk8Fo4lZw3smSs4UE47urSA1qMuhqRdxvr2PmakcPmSMZoi4a0aEhb1lazEfmC1tt2Qyrt_EO3OLX9yrSCR-2UajTztQxKQwBoUqpUcNxEALwj8hZtb9EFwcDe9XULMFqkzrL7KpMoQuQ5InuDnrBQ_bB54z124-cwcpilymhsfr1txn9i8lsbu3PoI4XEjbOEsTxdO9v2lTjSE0mjR6QauOHgnYct7eQs04gLwI5cVs__xyS9IPcASXLMoeN6j-ysFufxJaC1VfMqr8K_fm0_mQ
  priority: 102
  providerName: Scholars Portal
Title Natural diterpenes from coffee, cafestol and kahweol induce apoptosis through regulation of specificity protein 1 expression in human malignant pleural mesothelioma
URI https://www.ncbi.nlm.nih.gov/pubmed/22734486
https://www.proquest.com/docview/1036978687
https://search.proquest.com/docview/1434017915
https://pubmed.ncbi.nlm.nih.gov/PMC3431247
https://doaj.org/article/32e6a55b60c94d569968ff75da28e045
Volume 19
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3fb9MwELa2IRAvCAaMwqiMhAQPZLUTx3Eet2ndhNRqQkzqW-T4x1bRJlHbCfh_-EO5c5NqEW-8WFHtVE7uzv4uvvuOkI_MlolymYu4smkkLFdRqQ2LrDMxg8bbQOozmcqrG_F1ls72SNrlwoSgfVPOT6rF8qSa34XYymZpRl2c2Oh6cp7ArheLbLRP9kFBOxe9PTpI81AVD0tWA3TMWMvnw5UcccAOEZ61RjyPJBaBi5HdRWAi9YNdKZD3_7tEP9ij-vGTDzak8XPyrEWS9HQ74xdkz1WH5PG2tuTvQ_Jk0p6avyR_pjqwa1CL-cYNrm4U00qoqb137gs12mOBmQXVlaU_9N1PB9fgrIPYqW7qZlOv52valvShq235ehAorT3FVE0MNwI0TwPpw7yinLpfbYBtBf9DQyFAugTIf4txN7RZuDCfpVtjAthiXi_1K3Izvvh-fhW11RkiI9NkE8VWMiuM1cghr3UipNE2kXlZwsJlSiWMS3xuUu0AsVgutXIlM8wbLZkX1ievyUFVV-4NoYAyjEx06rVRgjNWxjbRsc65AYDoZDYgnzvpFM2WhKMIzouSBcq0QJkWPC8kG5AzlN5uGLJnhx_q1W3R6lCRxE7qNC0lM7mwqQSfT3mfpVbHygHGHZBPKPsCbRwEbHSbqgCzRbas4jQNvIngbA7IcW8k2Kbpd3faU7RrwxpmDm8pUxK7P-y68U6Md6tcfQ9jRCJwreQwl6Otsu0eqdPZAcl6ath75n4PGFJgDm8N5-1_3_mOPAXEGGOsXCyPycFmde_eAyrblEOwxVkGrRpfDsmjs4vp9bdh-MIB7eWMQzsRahhs9S-TFT-a
link.rule.ids 230,315,730,783,787,867,888,2109,2228,12068,12777,21400,24330,27936,27937,31731,31732,33385,33386,33756,33757,43322,43612,43817,53804,53806
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1bb9MwFLZgiMsLgnELDDASEjwQzUkcx3lCAzEKrH3apL1Zji9bRZuEthPwf_ihnOO63SIkXqqodiJHxz7-TnzO9xHymtmmkK5yaSZtmXKbybTRhqXWmZzBj7eB1Gc8EaMT_vW0PI0f3JYxrXLjE4Ojtp3Bb-SwugsBEY-Q1fv-R4qqUXi6GiU0rpMbvIC9GivFDz9vTxHKOgjkoXo1oMiKRWqfTIr9DGBEiseuaVangZ_yclcK5P3_uugre9Qwf_LKhnR4j9yNSJIerE1_n1xz7S65udaW_L1Lbo3jqfkD8meiA7sGtVhv3KN3o1hWQk3nvXPvqNEeBWZmVLeWftfnPx1cQ7AOZqe67_pVt5wuaZT0oYu1fD0YlHaeYqkmphsBmqeB9GHa0oy6XzHBtoXn0CAESOcA-c8w74b2MxfGM3dLLACbTbu5fkhODj8dfxylUZ0hNaIsVmluBbPcWI0c8loXXBhtwUZNA47LNJIbV_jalNoBYrGZ0NI1zDBvtGCeW188Ijtt17onhALKMKLQpddG8oyxJreFznWdGQCITlQJebuxjurXJBwqBC9SKDSkQkOqrFaCJeQDWm_bDdmzwx_d4kzFxaiK3Aldlo1gpua2FBDzSe-r0upcOsC4CXmDtle4xsHARsdSBRgtsmWpgzLwJkKwmZC9QU9Ym2bYvJk9KvqGpbqcyQl5tW3GOzHfrXXdBfThBUdfmcFYHq8n2_aVcmQk4lIkpBpMw8E7D1va6XlgDi8ALua8evr_Yb0kt0fH4yN19GXy7Rm5AxAxx-S4XOyRndXiwj0HGLZqXoS19heIizOL
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwELdgiIkXBANGYYCRkOCBrHbsOMnjGFTjo9UemLQ3y_HHVtEmUdsJ-H_4Q7lz06oRb7xUUe1El9yd_Tv57neEvGGuEoXPfcILlyXS8SKpjGWJ8zZl8BNcJPUZT9TZhfxymV3utPqKSfu2mh7Xs_lxPb2OuZXt3A43eWLD8_GpgF0vlfmwdWF4m9wBn2VqE6h3BwhZGXvjYeNqAJA561h9eKGGHBBEgieuCS8Tha3gUuR4kVhOvbM3RQr_fxfqnZ2qn0W5sy2NHpD7HZ6kJ2u5H5Jbvj4gd9cdJn8fkP1xd3b-iPyZmMixQR1WHbe4xlEsLqG2CcH799SagG1mZtTUjv4w1z89XEPIDsqnpm3aVbOcLmnX2Icu1k3sQa20CRQLNjHpCDA9jdQP05py6n91abY1PIfGdoB0DsD_CrNvaDvzUZ65X2IZ2GzazM1jcjH69P30LOl6NCRWZWKVpE4xJ60zyCRvjJDKGidUWVWwfNmqkNaLUNrMeMAtjitT-IpZFqxRLEgXxBOyVze1f0ooYA2rhMmCsYXkjFWpEyY1JbcAE73KB-TdRju6XVNx6BjCFEqjTjXqVPNSKzYgH1B722nIoR3_aBZXurMkLVKvTJZVitlSukxB5FeEkGfOpIUHpDsgb1H3Gj0dFGxNV7AA0iJnlj7JInsihJwDctSbCR5q-8Mb69HdCrEEyeEr5YXC4dfbYbwTs95q39zAHCkkrpgcZDlcG9v2lTY2OyB5zwx779wfAXeK_OGd-zz77ztfkf3zjyP97fPk63NyDyBkislzqToie6vFjX8BMG1VvYwO-RekST3c
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Natural+diterpenes+from+coffee%2C+cafestol+and+kahweol+induce+apoptosis+through+regulation+of+specificity+protein+1+expression+in+human+malignant+pleural+mesothelioma&rft.jtitle=Journal+of+biomedical+science&rft.au=Lee+Kyung-Ae&rft.au=Chae+Jung-Il&rft.au=Shim+Jung-Hyun&rft.date=2012-06-26&rft.pub=BMC&rft.issn=1021-7770&rft.eissn=1423-0127&rft.volume=19&rft.issue=1&rft.spage=60&rft_id=info:doi/10.1186%2F1423-0127-19-60&rft.externalDBID=DOA&rft.externalDocID=oai_doaj_org_article_32e6a55b60c94d569968ff75da28e045
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1423-0127&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1423-0127&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1423-0127&client=summon