Luteolin delays photoreceptor degeneration in a mouse model of retinitis pigmentosa

• Published in: Neural regeneration research Vol. 16; no. 10; pp. 2109 - 2120
• Main Authors: Liu, Xiao-Bin, Liu, Feng, Liang, Yi-Yao, Yin, Gang, Zhang, Hui-Jun, Mi, Xue-Song, Zhang, Zai-Jun, So, Kwok-Fai, Li, Ang, Xu, Ying
• Format: Journal Article
• Language: English
• Published: India Wolters Kluwer India Pvt. Ltd 01.10.2021; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; Co-Innovation Center of Neuroregeneration,Nantong University,Nantong,Jiangsu Province,China%Guangdong-Hong Kong-Macau Institute of CNS Regeneration,Ministry of Education CNS Regeneration Collaborative Joint Laboratory,Jinan University,Guangzhou,Guangdong Province,China; Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory),Guangzhou,Guangdong Province,China%Guangdong-Hong Kong-Macau Institute of CNS Regeneration,Ministry of Education CNS Regeneration Collaborative Joint Laboratory,Jinan University,Guangzhou,Guangdong Province,China; Co-Innovation Center of Neuroregeneration,Nantong University,Nantong,Jiangsu Province,China; Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory),Guangzhou,Guangdong Province,China; Guangdong-Hong Kong-Macau Institute of CNS Regeneration,Ministry of Education CNS Regeneration Collaborative Joint Laboratory,Jinan University,Guangzhou,Guangdong Province,China%Institute of New Drug Research and Guangzhou Key Laboratory of Innovative Chemical Drug Research in Cardio-cerebrovascular Diseases,Jinan University,Guangzhou,Guangdong Province,China%Department of Ophthalmology,the First Affiliated Hospital of Jinan University,Guangzhou,Guangdong Province,China%Guangdong-Hong Kong-Macau Institute of CNS Regeneration,Ministry of Education CNS Regeneration Collaborative Joint Laboratory,Jinan University,Guangzhou,Guangdong Province,China; Wolters Kluwer - Medknow; Wolters Kluwer Medknow Publications
• Subjects: anti-inflammation; apoptosis; flavonoid; jnk pathway; luteolin; photoreceptor; reactive gliosis; reactive oxygen species; retinal degeneration; retinitis pigmentosa; Bioflavonoids; Care and treatment; Cell receptors; Cytokines; Degeneration (Pathology); Development and progression; Flavones; Flavonoids; Genetic aspects; Health aspects; Photoreceptors; Reactive oxygen species; Retinitis pigmentosa; China; JNK pathway; luteolin; retinal degeneration; reactive gliosis; photoreceptor; reactive oxygen species; retinitis pigmentosa; apoptosis; anti-inflammation; flavonoid

Luteolin is neuroprotective for retinal ganglion cells and retinal pigment epithelial cells after oxidative injury, whereby it can inhibit microglial neurotoxicity. Therefore, luteolin holds the potential to be useful for treatment of retinal diseases. The purpose of this study was to investigate wh...