Luteolin delays photoreceptor degeneration in a mouse model of retinitis pigmentosa
Luteolin is neuroprotective for retinal ganglion cells and retinal pigment epithelial cells after oxidative injury, whereby it can inhibit microglial neurotoxicity. Therefore, luteolin holds the potential to be useful for treatment of retinal diseases. The purpose of this study was to investigate wh...
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| Abstract | Luteolin is neuroprotective for retinal ganglion cells and retinal pigment epithelial cells after oxidative injury, whereby it can inhibit microglial neurotoxicity. Therefore, luteolin holds the potential to be useful for treatment of retinal diseases. The purpose of this study was to investigate whether luteolin exhibits neuroprotective effects on rod cells in rd10 mice, a slow photoreceptor-degenerative model of retinitis pigmentosa. Luteolin (100 mg/kg) intraperitoneally injected daily from postnatal day 14 (P14) to P25 significantly enhanced the visual performance and retinal light responses of rd10 mice at P25. Moreover, it increased the survival of photoreceptors and improved retinal structure. Mechanistically, luteolin treatment attenuated increases in reactive oxygen species, photoreceptor apoptosis, and reactive gliosis; increased mRNA levels of anti-inflammatory cytokines while lowering that of pro-inflammatory and chemoattractant cytokines; and lowered the ratio of phospho-JNK/JNK. Application of the JNK inhibitor SP600125 exerted a similar protective effect to luteolin, suggesting that luteolin delays photoreceptor degeneration and functional deterioration in rd10 mice through regulation of retinal oxidation and inflammation by inhibiting the JNK pathway. Therefore, luteolin may be useful as a supplementary treatment for retinitis pigmentosa. This study was approved by the Qualified Ethics Committee of Jinan University, China (approval No. IACUC-20181217-02) on December 17, 2018. |
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| AbstractList | Luteolin is neuroprotective for retinal ganglion cells and retinal pigment epithelial cells after oxidative injury, whereby it can inhibit microglial neurotoxicity. Therefore, luteolin holds the potential to be useful for treatment of retinal diseases. The purpose of this study was to investigate whether luteolin exhibits neuroprotective effects on rod cells in rd10 mice, a slow photoreceptor-degenerative model of retinitis pigmentosa. Luteolin (100 mg/kg) intraperitoneally injected daily from postnatal day 14 (P14) to P25 significantly enhanced the visual performance and retinal light responses of rd10 mice at P25. Moreover, it increased the survival of photoreceptors and improved retinal structure. Mechanistically, luteolin treatment attenuated increases in reactive oxygen species, photoreceptor apoptosis, and reactive gliosis; increased mRNA levels of anti-inflammatory cytokines while lowering that of pro-inflammatory and chemoattractant cytokines; and lowered the ratio of phospho-JNK/JNK. Application of the JNK inhibitor SP600125 exerted a similar protective effect to luteolin, suggesting that luteolin delays photoreceptor degeneration and functional deterioration in rd10 mice through regulation of retinal oxidation and inflammation by inhibiting the JNK pathway. Therefore, luteolin may be useful as a supplementary treatment for retinitis pigmentosa. This study was approved by the Qualified Ethics Committee of Jinan University, China (approval No. IACUC-20181217-02) on December 17, 2018. Luteolin is neuroprotective for retinal ganglion cells and retinal pigment epithelial cells after oxidative injury, whereby it can inhibit microglial neurotoxicity. Therefore, luteolin holds the potential to be useful for treatment of retinal diseases. The purpose of this study was to investigate whether luteolin exhibits neuroprotective effects on rod cells in rd10 mice, a slow photoreceptor-degenerative model of retinitis pigmentosa. Luteolin (100 mg/kg) intraperitoneally injected daily from postnatal day 14 (P14) to P25 significantly enhanced the visual performance and retinal light responses of rd10 mice at P25. Moreover, it increased the survival of photoreceptors and improved retinal structure. Mechanistically, luteolin treatment attenuated increases in reactive oxygen species, photoreceptor apoptosis, and reactive gliosis; increased mRNA levels of anti-inflammatory cytokines while lowering that of pro-inflammatory and chemoattractant cytokines; and lowered the ratio of phospho-JNK/JNK. Application of the JNK inhibitor SP600125 exerted a similar protective effect to luteolin, suggesting that luteolin delays photoreceptor degeneration and functional deterioration in rd10 mice through regulation of retinal oxidation and inflammation by inhibiting the JNK pathway. Therefore, luteolin may be useful as a supplementary treatment for retinitis pigmentosa. This study was approved by the Qualified Ethics Committee of Jinan University, China (approval No. IACUC-20181217-02) on December 17, 2018.Luteolin is neuroprotective for retinal ganglion cells and retinal pigment epithelial cells after oxidative injury, whereby it can inhibit microglial neurotoxicity. Therefore, luteolin holds the potential to be useful for treatment of retinal diseases. The purpose of this study was to investigate whether luteolin exhibits neuroprotective effects on rod cells in rd10 mice, a slow photoreceptor-degenerative model of retinitis pigmentosa. Luteolin (100 mg/kg) intraperitoneally injected daily from postnatal day 14 (P14) to P25 significantly enhanced the visual performance and retinal light responses of rd10 mice at P25. Moreover, it increased the survival of photoreceptors and improved retinal structure. Mechanistically, luteolin treatment attenuated increases in reactive oxygen species, photoreceptor apoptosis, and reactive gliosis; increased mRNA levels of anti-inflammatory cytokines while lowering that of pro-inflammatory and chemoattractant cytokines; and lowered the ratio of phospho-JNK/JNK. Application of the JNK inhibitor SP600125 exerted a similar protective effect to luteolin, suggesting that luteolin delays photoreceptor degeneration and functional deterioration in rd10 mice through regulation of retinal oxidation and inflammation by inhibiting the JNK pathway. Therefore, luteolin may be useful as a supplementary treatment for retinitis pigmentosa. This study was approved by the Qualified Ethics Committee of Jinan University, China (approval No. IACUC-20181217-02) on December 17, 2018. R453%R774.6%Q429+.2; Luteolin is neuroprotective for retinal ganglion cells and retinal pigment epithelial cells after oxidative injury, whereby it can inhibit microglial neurotoxicity. Therefore, luteolin holds the potential to be useful for treatment of retinal diseases. The purpose of this study was to investigate whether luteolin exhibits neuroprotective effects on rod cells in rd10 mice, a slow photoreceptor-degenerative model of retinitis pigmentosa. Luteolin (100 mg/kg) intraperitoneally injected daily from postnatal day 14 (P14) to P25 significantly enhanced the visual performance and retinal light responses of rd10 mice at P25. Moreover, it increased the survival of photoreceptors and improved retinal structure. Mechanistically, luteolin treatment attenuated increases in reactive oxygen species, photoreceptor apoptosis, and reactive gliosis;increased mRNA levels of anti-inflammatory cytokines while lowering that of pro-inflammatory and chemoattractant cytokines;and lowered the ratio of phospho-JNK/JNK. Application of the JNK inhibitor SP600125 exerted a similar protective effect to luteolin, suggesting that luteolin delays photoreceptor degeneration and functional deterioration in rd10 mice through regulation of retinal oxidation and inflammation by inhibiting the JNK pathway. Therefore, luteolin may be useful as a supplementary treatment for retinitis pigmentosa. This study was approved by the Qualified Ethics Committee of Jinan University, China (approval No. IACUC-20181217-02) on December 17, 2018. |
| Audience | Academic |
| Author | Zhang, Hui-Jun Liang, Yi-Yao Liu, Xiao-Bin Yin, Gang Xu, Ying Zhang, Zai-Jun So, Kwok-Fai Liu, Feng Li, Ang Mi, Xue-Song |
| AuthorAffiliation | Guangdong-Hong Kong-Macau Institute of CNS Regeneration,Ministry of Education CNS Regeneration Collaborative Joint Laboratory,Jinan University,Guangzhou,Guangdong Province,China%Institute of New Drug Research and Guangzhou Key Laboratory of Innovative Chemical Drug Research in Cardio-cerebrovascular Diseases,Jinan University,Guangzhou,Guangdong Province,China%Department of Ophthalmology,the First Affiliated Hospital of Jinan University,Guangzhou,Guangdong Province,China%Guangdong-Hong Kong-Macau Institute of CNS Regeneration,Ministry of Education CNS Regeneration Collaborative Joint Laboratory,Jinan University,Guangzhou,Guangdong Province,China;Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory),Guangzhou,Guangdong Province,China;Co-Innovation Center of Neuroregeneration,Nantong University,Nantong,Jiangsu Province,China%Guangdong-Hong Kong-Macau Institute of CNS Regeneration,Ministry of Education CNS Regeneration Collaborative Joint Laboratory,Jinan Uni |
| AuthorAffiliation_xml | – name: Guangdong-Hong Kong-Macau Institute of CNS Regeneration,Ministry of Education CNS Regeneration Collaborative Joint Laboratory,Jinan University,Guangzhou,Guangdong Province,China%Institute of New Drug Research and Guangzhou Key Laboratory of Innovative Chemical Drug Research in Cardio-cerebrovascular Diseases,Jinan University,Guangzhou,Guangdong Province,China%Department of Ophthalmology,the First Affiliated Hospital of Jinan University,Guangzhou,Guangdong Province,China%Guangdong-Hong Kong-Macau Institute of CNS Regeneration,Ministry of Education CNS Regeneration Collaborative Joint Laboratory,Jinan University,Guangzhou,Guangdong Province,China;Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory),Guangzhou,Guangdong Province,China;Co-Innovation Center of Neuroregeneration,Nantong University,Nantong,Jiangsu Province,China%Guangdong-Hong Kong-Macau Institute of CNS Regeneration,Ministry of Education CNS Regeneration Collaborative Joint Laboratory,Jinan University,Guangzhou,Guangdong Province,China;Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory),Guangzhou,Guangdong Province,China%Guangdong-Hong Kong-Macau Institute of CNS Regeneration,Ministry of Education CNS Regeneration Collaborative Joint Laboratory,Jinan University,Guangzhou,Guangdong Province,China;Co-Innovation Center of Neuroregeneration,Nantong University,Nantong,Jiangsu Province,China – name: 4 Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory), Guangzhou, Guangdong Province, China – name: 1 Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Ministry of Education CNS Regeneration Collaborative Joint Laboratory, Jinan University, Guangzhou, Guangdong Province, China – name: 2 Institute of New Drug Research and Guangzhou Key Laboratory of Innovative Chemical Drug Research in Cardio-cerebrovascular Diseases, Jinan University, Guangzhou, Guangdong Province, China – name: 3 Department of Ophthalmology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong Province, China – name: 5 Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu Province, China |
| Author_xml | – sequence: 1 givenname: Xiao-Bin surname: Liu fullname: Liu, Xiao-Bin organization: Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Ministry of Education CNS Regeneration Collaborative Joint Laboratory, Jinan University, Guangzhou, Guangdong Province – sequence: 2 givenname: Feng surname: Liu fullname: Liu, Feng organization: Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Ministry of Education CNS Regeneration Collaborative Joint Laboratory, Jinan University, Guangzhou, Guangdong Province – sequence: 3 givenname: Yi-Yao surname: Liang fullname: Liang, Yi-Yao organization: Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Ministry of Education CNS Regeneration Collaborative Joint Laboratory, Jinan University, Guangzhou, Guangdong Province – sequence: 4 givenname: Gang surname: Yin fullname: Yin, Gang organization: Institute of New Drug Research and Guangzhou Key Laboratory of Innovative Chemical Drug Research in Cardio-cerebrovascular Diseases, Jinan University, Guangzhou, Guangdong Province – sequence: 5 givenname: Hui-Jun surname: Zhang fullname: Zhang, Hui-Jun organization: Department of Ophthalmology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong Province – sequence: 6 givenname: Xue-Song surname: Mi fullname: Mi, Xue-Song organization: Department of Ophthalmology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong Province – sequence: 7 givenname: Zai-Jun surname: Zhang fullname: Zhang, Zai-Jun organization: Institute of New Drug Research and Guangzhou Key Laboratory of Innovative Chemical Drug Research in Cardio-cerebrovascular Diseases, Jinan University, Guangzhou, Guangdong Province – sequence: 8 givenname: Kwok-Fai surname: So fullname: So, Kwok-Fai organization: Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Ministry of Education CNS Regeneration Collaborative Joint Laboratory, Jinan University; Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory), Guangzhou, Guangdong Province; Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu Province – sequence: 9 givenname: Ang surname: Li fullname: Li, Ang organization: Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Ministry of Education CNS Regeneration Collaborative Joint Laboratory, Jinan University; Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory), Guangzhou, Guangdong Province – sequence: 10 givenname: Ying surname: Xu fullname: Xu, Ying organization: Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Ministry of Education CNS Regeneration Collaborative Joint Laboratory, Jinan University, Guangzhou, Guangdong Province; Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu Province |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33642401$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1155_2021_5838101 crossref_primary_10_1371_journal_pone_0302742 crossref_primary_10_1002_jnr_25021 crossref_primary_10_3390_antibiotics10111373 crossref_primary_10_1016_j_phymed_2025_156523 crossref_primary_10_3389_fnins_2022_868750 crossref_primary_10_1016_j_jmbbm_2021_105055 crossref_primary_10_4103_1673_5374_330622 crossref_primary_10_1007_s44187_024_00247_9 crossref_primary_10_1039_D3FO02716C crossref_primary_10_4103_1673_5374_390958 crossref_primary_10_1021_acs_jafc_2c07735 crossref_primary_10_1177_09603271211063165 crossref_primary_10_3390_ijms24032136 |
| Cites_doi | 10.1167/iovs.04-0541 10.3389/fncel.2018.00203 10.1016/j.neuroscience.2008.06.042 10.1155/2013/480739 10.1080/10286020.2019.1642329 10.1167/iovs.05-0397 10.1167/iovs.13-12004 10.1016/j.neulet.2004.02.041 10.1016/j.yexcr.2017.06.024 10.1016/j.neuroscience.2014.09.013 10.1016/j.jns.2020.116679 10.1016/j.freeradbiomed.2004.01.001 10.1055/s-2007-967122 10.1016/j.bbrc.2012.12.004 10.1016/j.bcp.2018.06.003 10.1038/aps.2017.143 10.1093/brain/awg171 10.1016/j.neulet.2015.01.018 10.1002/cne.21144 10.5483/BMBRep.2017.50.1.114 10.4049/jimmunol.1900612 10.1046/j.1365-2222.2000.00768.x 10.1096/fj.03-0969fje 10.1167/iovs.11-8790 10.1378/chest.118.2.503 10.1007/s10753-017-0575-8 10.1038/srep17645 10.1155/2018/4623919 10.1093/hmg/ddw275 10.1155/2019/9682318 10.3892/mmr.2015.4287 10.1016/S0140-6736(06)69740-7 10.1038/s41598-017-11391-x 10.1073/pnas.1411248112 10.2147/OTT.S191158 10.1016/j.neuropharm.2014.07.012 10.3390/nu11040771 10.1038/eye.2015.236 10.1167/iovs.61.11.2 10.1016/j.fct.2010.06.029 10.1016/j.exer.2009.06.019 10.1016/S0165-5728(01)00303-4 10.1016/j.exer.2017.07.004 10.1186/1742-2094-7-3 10.1167/iovs.04-1369 10.3390/molecules18078083 10.1016/j.brainres.2006.10.031 10.1016/j.neuroscience.2015.04.060 10.1002/term.2522 10.1016/j.jnutbio.2010.01.011 10.1016/j.neuropharm.2018.06.027 10.1016/j.psyneuen.2019.104580 10.1177/1535370213477985 10.1038/srep07601 10.1007/978-0-387-34817-9_13 10.1016/j.exer.2015.04.015 10.1084/jem.20040819 10.1167/iovs.17-22881 10.1083/jcb.119.3.493 10.1016/j.lfs.2007.09.028 10.1016/j.bbrc.2014.05.036 10.1016/j.visres.2006.11.020 10.1016/j.carbon.2016.11.040 |
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| GrantInformation_xml | – fundername: The work was supported by the National Natural Science Foundation of China, Nos. 81470656 (to YX), 82071372 (to AL), 82074169 ; Guangdong Grant Key Technologies for Treatment of Brain Disorders', China, No. 2018B030332001 ; Ningxia Key Research and Development Program Grant (Yinchuan, Ningxia Hui Autonomous Region, China) ; Program of Introducing Talents of Discipline to Universities, China, No. B14036 ; (Outstanding Scholar Program of Bioland Laboratory ); and Science and Technology Program of Guangzhou, No. 202007030012 funderid: (to XSM); (to YX); (to KFS); (to YX, AL, KFS); (Outstanding Scholar Program of Bioland Laboratory ); (to KFS and AL) |
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| Keywords | JNK pathway luteolin retinal degeneration reactive gliosis photoreceptor reactive oxygen species retinitis pigmentosa apoptosis anti-inflammation flavonoid |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Author contributions: Study design: AL, YX; experiment performance: XBL, FL, YYL, GY, HJZ; data analysis: XBL, FL, GY, AL, YX; manuscript preparation: AL, YX; manuscript editing and review: XSM, ZJZ, KFS, AL, YX. All authors approved the final version of the paper. |
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| References | key-10.4103/1673-5374.303537-37 key-10.4103/1673-5374.303537-36 key-10.4103/1673-5374.303537-39 key-10.4103/1673-5374.303537-38 key-10.4103/1673-5374.303537-31 key-10.4103/1673-5374.303537-30 key-10.4103/1673-5374.303537-33 key-10.4103/1673-5374.303537-32 key-10.4103/1673-5374.303537-35 key-10.4103/1673-5374.303537-34 key-10.4103/1673-5374.303537-48 key-10.4103/1673-5374.303537-47 key-10.4103/1673-5374.303537-49 key-10.4103/1673-5374.303537-40 key-10.4103/1673-5374.303537-42 key-10.4103/1673-5374.303537-41 key-10.4103/1673-5374.303537-44 key-10.4103/1673-5374.303537-43 key-10.4103/1673-5374.303537-46 key-10.4103/1673-5374.303537-45 key-10.4103/1673-5374.303537-15 key-10.4103/1673-5374.303537-59 key-10.4103/1673-5374.303537-14 key-10.4103/1673-5374.303537-58 key-10.4103/1673-5374.303537-17 key-10.4103/1673-5374.303537-16 key-10.4103/1673-5374.303537-19 key-10.4103/1673-5374.303537-18 key-10.4103/1673-5374.303537-51 key-10.4103/1673-5374.303537-50 key-10.4103/1673-5374.303537-53 key-10.4103/1673-5374.303537-52 key-10.4103/1673-5374.303537-11 key-10.4103/1673-5374.303537-55 key-10.4103/1673-5374.303537-10 key-10.4103/1673-5374.303537-54 key-10.4103/1673-5374.303537-13 key-10.4103/1673-5374.303537-57 key-10.4103/1673-5374.303537-12 key-10.4103/1673-5374.303537-56 key-10.4103/1673-5374.303537-1 key-10.4103/1673-5374.303537-2 key-10.4103/1673-5374.303537-3 key-10.4103/1673-5374.303537-4 key-10.4103/1673-5374.303537-9 key-10.4103/1673-5374.303537-26 key-10.4103/1673-5374.303537-25 key-10.4103/1673-5374.303537-28 key-10.4103/1673-5374.303537-27 key-10.4103/1673-5374.303537-5 key-10.4103/1673-5374.303537-6 key-10.4103/1673-5374.303537-29 key-10.4103/1673-5374.303537-7 key-10.4103/1673-5374.303537-8 key-10.4103/1673-5374.303537-62 key-10.4103/1673-5374.303537-61 key-10.4103/1673-5374.303537-20 key-10.4103/1673-5374.303537-64 key-10.4103/1673-5374.303537-63 key-10.4103/1673-5374.303537-22 key-10.4103/1673-5374.303537-21 key-10.4103/1673-5374.303537-24 key-10.4103/1673-5374.303537-23 key-10.4103/1673-5374.303537-60 |
| References_xml | – ident: key-10.4103/1673-5374.303537-40 doi: 10.1167/iovs.04-0541 – ident: key-10.4103/1673-5374.303537-45 doi: 10.3389/fncel.2018.00203 – ident: key-10.4103/1673-5374.303537-4 doi: 10.1016/j.neuroscience.2008.06.042 – ident: key-10.4103/1673-5374.303537-41 doi: 10.1155/2013/480739 – ident: key-10.4103/1673-5374.303537-54 doi: 10.1080/10286020.2019.1642329 – ident: key-10.4103/1673-5374.303537-31 doi: 10.1167/iovs.05-0397 – ident: key-10.4103/1673-5374.303537-15 doi: 10.1167/iovs.13-12004 – ident: key-10.4103/1673-5374.303537-50 doi: 10.1016/j.neulet.2004.02.041 – ident: key-10.4103/1673-5374.303537-59 doi: 10.1016/j.yexcr.2017.06.024 – ident: key-10.4103/1673-5374.303537-12 doi: 10.1016/j.neuroscience.2014.09.013 – ident: key-10.4103/1673-5374.303537-52 doi: 10.1016/j.jns.2020.116679 – ident: key-10.4103/1673-5374.303537-53 doi: 10.1016/j.freeradbiomed.2004.01.001 – ident: key-10.4103/1673-5374.303537-16 – ident: key-10.4103/1673-5374.303537-64 doi: 10.1055/s-2007-967122 – ident: key-10.4103/1673-5374.303537-38 doi: 10.1016/j.bbrc.2012.12.004 – ident: key-10.4103/1673-5374.303537-58 doi: 10.1016/j.bcp.2018.06.003 – ident: key-10.4103/1673-5374.303537-27 doi: 10.1038/aps.2017.143 – ident: key-10.4103/1673-5374.303537-36 doi: 10.1093/brain/awg171 – ident: key-10.4103/1673-5374.303537-57 doi: 10.1016/j.neulet.2015.01.018 – ident: key-10.4103/1673-5374.303537-10 doi: 10.1002/cne.21144 – ident: key-10.4103/1673-5374.303537-1 doi: 10.5483/BMBRep.2017.50.1.114 – ident: key-10.4103/1673-5374.303537-60 doi: 10.4049/jimmunol.1900612 – ident: key-10.4103/1673-5374.303537-25 doi: 10.1046/j.1365-2222.2000.00768.x – ident: key-10.4103/1673-5374.303537-17 doi: 10.1096/fj.03-0969fje – ident: key-10.4103/1673-5374.303537-34 doi: 10.1167/iovs.11-8790 – ident: key-10.4103/1673-5374.303537-8 doi: 10.1378/chest.118.2.503 – ident: key-10.4103/1673-5374.303537-46 doi: 10.1007/s10753-017-0575-8 – ident: key-10.4103/1673-5374.303537-22 doi: 10.1038/srep17645 – ident: key-10.4103/1673-5374.303537-28 doi: 10.1155/2018/4623919 – ident: key-10.4103/1673-5374.303537-49 doi: 10.1093/hmg/ddw275 – ident: key-10.4103/1673-5374.303537-37 doi: 10.1155/2019/9682318 – ident: key-10.4103/1673-5374.303537-21 doi: 10.3892/mmr.2015.4287 – ident: key-10.4103/1673-5374.303537-14 doi: 10.1016/S0140-6736(06)69740-7 – ident: key-10.4103/1673-5374.303537-20 doi: 10.1038/s41598-017-11391-x – ident: key-10.4103/1673-5374.303537-23 doi: 10.1073/pnas.1411248112 – ident: key-10.4103/1673-5374.303537-61 doi: 10.2147/OTT.S191158 – ident: key-10.4103/1673-5374.303537-35 doi: 10.1016/j.neuropharm.2014.07.012 – ident: key-10.4103/1673-5374.303537-44 doi: 10.3390/nu11040771 – ident: key-10.4103/1673-5374.303537-26 doi: 10.1038/eye.2015.236 – ident: key-10.4103/1673-5374.303537-43 doi: 10.1167/iovs.61.11.2 – ident: key-10.4103/1673-5374.303537-7 doi: 10.1016/j.fct.2010.06.029 – ident: key-10.4103/1673-5374.303537-3 doi: 10.1016/j.exer.2009.06.019 – ident: key-10.4103/1673-5374.303537-32 doi: 10.1016/S0165-5728(01)00303-4 – ident: key-10.4103/1673-5374.303537-62 doi: 10.1016/j.exer.2017.07.004 – ident: key-10.4103/1673-5374.303537-9 doi: 10.1186/1742-2094-7-3 – ident: key-10.4103/1673-5374.303537-13 doi: 10.1167/iovs.04-1369 – ident: key-10.4103/1673-5374.303537-55 doi: 10.3390/molecules18078083 – ident: key-10.4103/1673-5374.303537-2 doi: 10.1016/j.brainres.2006.10.031 – ident: key-10.4103/1673-5374.303537-33 doi: 10.1016/j.neuroscience.2015.04.060 – ident: key-10.4103/1673-5374.303537-19 doi: 10.1002/term.2522 – ident: key-10.4103/1673-5374.303537-24 doi: 10.1016/j.jnutbio.2010.01.011 – ident: key-10.4103/1673-5374.303537-56 doi: 10.1016/j.neuropharm.2018.06.027 – ident: key-10.4103/1673-5374.303537-63 doi: 10.1016/j.psyneuen.2019.104580 – ident: key-10.4103/1673-5374.303537-30 doi: 10.1177/1535370213477985 – ident: key-10.4103/1673-5374.303537-51 doi: 10.1038/srep07601 – ident: key-10.4103/1673-5374.303537-42 doi: 10.1007/978-0-387-34817-9_13 – ident: key-10.4103/1673-5374.303537-48 doi: 10.1016/j.exer.2015.04.015 – ident: key-10.4103/1673-5374.303537-18 doi: 10.1084/jem.20040819 – ident: key-10.4103/1673-5374.303537-29 doi: 10.1167/iovs.17-22881 – ident: key-10.4103/1673-5374.303537-11 doi: 10.1083/jcb.119.3.493 – ident: key-10.4103/1673-5374.303537-6 doi: 10.1016/j.lfs.2007.09.028 – ident: key-10.4103/1673-5374.303537-39 doi: 10.1016/j.bbrc.2014.05.036 – ident: key-10.4103/1673-5374.303537-5 doi: 10.1016/j.visres.2006.11.020 – ident: key-10.4103/1673-5374.303537-47 doi: 10.1016/j.carbon.2016.11.040 |
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| Snippet | Luteolin is neuroprotective for retinal ganglion cells and retinal pigment epithelial cells after oxidative injury, whereby it can inhibit microglial... R453%R774.6%Q429+.2; Luteolin is neuroprotective for retinal ganglion cells and retinal pigment epithelial cells after oxidative injury, whereby it can inhibit... |
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| SubjectTerms | anti-inflammation; apoptosis; flavonoid; jnk pathway; luteolin; photoreceptor; reactive gliosis; reactive oxygen species; retinal degeneration; retinitis pigmentosa Bioflavonoids Care and treatment Cell receptors Cytokines Degeneration (Pathology) Development and progression Flavones Flavonoids Genetic aspects Health aspects Photoreceptors Reactive oxygen species Retinitis pigmentosa |
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| Title | Luteolin delays photoreceptor degeneration in a mouse model of retinitis pigmentosa |
| URI | http://www.nrronline.org/article.asp?issn=1673-5374;year=2021;volume=16;issue=10;spage=2109;epage=2120;aulast=Liu;type=0 https://www.ncbi.nlm.nih.gov/pubmed/33642401 https://www.proquest.com/docview/2532908240 https://www.proquest.com/docview/2494875370 https://d.wanfangdata.com.cn/periodical/zgsjzsyj-e202110041 https://pubmed.ncbi.nlm.nih.gov/PMC8343326 https://doaj.org/article/4b1422e7fe3944b38dffb9213ce928c7 |
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