Polyphenols-gut microbiota interplay and brain neuromodulation

Increasing evidence suggests that food ingested polyphenols can have beneficial effects in neuronal protection acting against oxidative stress and inflammatory injury. Moreover, polyphenols have been reported to promote cognitive functions. Biotransformation of polyphenols is needed to obtain metabo...

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Published inNeural regeneration research Vol. 13; no. 12; pp. 2055 - 2059
Main Authors Filosa, Stefania, Di Meo, Francesco, Crispi, Stefania
Format Journal Article
LanguageEnglish
Published India Wolters Kluwer India Pvt. Ltd 01.12.2018
Medknow Publications and Media Pvt. Ltd
Medknow Publications & Media Pvt. Ltd
Institute of Biosciences and Bioresources, National Research Council, National Research Council, via P. Castellino, Naples, Italy
Istituto di Ricovero e Cura a Carattere Scientifico Neuromed, Pozzilli, Italy%Institute of Biosciences and Bioresources, National Research Council, National Research Council, via P. Castellino, Naples, Italy
Medknow Publications & Media Pvt Ltd
Wolters Kluwer Medknow Publications
Subjects
Animal cognition
Antioxidants
Bacteria
Bioavailability
Biological activity
Blood-brain barrier
Enzymes
Gut microbiota
Homeostasis
Metabolism
Metabolites
Microbiota
Microbiota (Symbiotic organisms)
Nervous system
Neurodegeneration
Organic chemicals
Pathogens
Polyphenols
polyphenols; gut-microbiota; gut-brain axis; metagenomic; neurodegeneration; neurotransmitters; prebiotics; probiotics
Prebiotics
Probiotics
Review
polyphenols
neurotransmitters
metagenomic
neurodegeneration
prebiotics
gut-microbiota
gut-brain axis
probiotics
Online AccessGet full text

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Abstract Increasing evidence suggests that food ingested polyphenols can have beneficial effects in neuronal protection acting against oxidative stress and inflammatory injury. Moreover, polyphenols have been reported to promote cognitive functions. Biotransformation of polyphenols is needed to obtain metabolites active in brain and it occurs through their processing by gut microbiota. Polyphenols metabolites could directly act as neurotransmitters crossing the blood-brain barrier or indirectly by modulating the cerebrovascular system. The microbiota-gut-brain axis is considered a neuroendocrine system that acts bidirectionally and plays an important role in stress responses. The metabolites produced by microbiota metabolism can modulate gut bacterial composition and brain biochemistry acting as neurotransmitters in the central nervous system. Gut microbiota composition can be influenced by dietary ingestion of natural bioactive molecules such as probiotics, prebiotics and polyphenol. Microbiota composition can be altered by dietary changes and gastrointestinal dysfunctions are observed in neurodegenerative diseases. In addition, several pieces of evidence support the idea that alterations in gut microbiota and enteric neuroimmune system could contribute to onset and progression of these age-related disorders. The impact of polyphenols on microbiota composition strengthens the idea that maintaining a healthy microbiome by modulating diet is essential for having a healthy brain across the lifespan. Moreover, it is emerging that they could be used as novel therapeutics to prevent brain from neurodegeneration.
AbstractList Increasing evidence suggests that food ingested polyphenols can have beneficial effects in neuronal protec-tion acting against oxidative stress and inflammatory injury. Moreover, polyphenols have been reported to promote cognitive functions. Biotransformation of polyphenols is needed to obtain metabolites active in brain and it occurs through their processing by gut microbiota. Polyphenols metabolites could directly act as neurotransmitters crossing the blood-brain barrier or indirectly by modulating the cerebrovascular system. The microbiota-gut-brain axis is considered a neuroendocrine system that acts bidirectionally and plays an important role in stress responses. The metabolites produced by microbiota metabolism can mod-ulate gut bacterial composition and brain biochemistry acting as neurotransmitters in the central nervous system. Gut microbiota composition can be influenced by dietary ingestion of natural bioactive molecules such as probiotics, prebiotics and polyphenol. Microbiota composition can be altered by dietary changes and gastrointestinal dysfunctions are observed in neurodegenerative diseases. In addition, several pieces of evidence support the idea that alterations in gut microbiota and enteric neuroimmune system could con-tribute to onset and progression of these age-related disorders. The impact of polyphenols on microbiota composition strengthens the idea that maintaining a healthy microbiome by modulating diet is essential for having a healthy brain across the lifespan. Moreover, it is emerging that they could be used as novel therapeutics to prevent brain from neurodegeneration.
Increasing evidence suggests that food ingested polyphenols can have beneficial effects in neuronal protection acting against oxidative stress and inflammatory injury. Moreover, polyphenols have been reported to promote cognitive functions. Biotransformation of polyphenols is needed to obtain metabolites active in brain and it occurs through their processing by gut microbiota. Polyphenols metabolites could directly act as neurotransmitters crossing the blood-brain barrier or indirectly by modulating the cerebrovascular system. The microbiota-gut-brain axis is considered a neuroendocrine system that acts bidirectionally and plays an important role in stress responses. The metabolites produced by microbiota metabolism can modulate gut bacterial composition and brain biochemistry acting as neurotransmitters in the central nervous system. Gut microbiota composition can be influenced by dietary ingestion of natural bioactive molecules such as probiotics, prebiotics and polyphenol. Microbiota composition can be altered by dietary changes and gastrointestinal dysfunctions are observed in neurodegenerative diseases. In addition, several pieces of evidence support the idea that alterations in gut microbiota and enteric neuroimmune system could contribute to onset and progression of these age-related disorders. The impact of polyphenols on microbiota composition strengthens the idea that maintaining a healthy microbiome by modulating diet is essential for having a healthy brain across the lifespan. Moreover, it is emerging that they could be used as novel therapeutics to prevent brain from neurodegeneration.
Increasing evidence suggests that food ingested polyphenols can have beneficial effects in neuronal protection acting against oxidative stress and inflammatory injury. Moreover, polyphenols have been reported to promote cognitive functions. Biotransformation of polyphenols is needed to obtain metabolites active in brain and it occurs through their processing by gut microbiota. Polyphenols metabolites could directly act as neurotransmitters crossing the blood-brain barrier or indirectly by modulating the cerebrovascular system. The microbiota-gut-brain axis is considered a neuroendocrine system that acts bidirectionally and plays an important role in stress responses. The metabolites produced by microbiota metabolism can modulate gut bacterial composition and brain biochemistry acting as neurotransmitters in the central nervous system. Gut microbiota composition can be influenced by dietary ingestion of natural bioactive molecules such as probiotics, prebiotics and polyphenol. Microbiota composition can be altered by dietary changes and gastrointestinal dysfunctions are observed in neurodegenerative diseases. In addition, several pieces of evidence support the idea that alterations in gut microbiota and enteric neuroimmune system could contribute to onset and progression of these age-related disorders. The impact of polyphenols on microbiota composition strengthens the idea that maintaining a healthy microbiome by modulating diet is essential for having a healthy brain across the lifespan. Moreover, it is emerging that they could be used as novel therapeutics to prevent brain from neurodegeneration.Increasing evidence suggests that food ingested polyphenols can have beneficial effects in neuronal protection acting against oxidative stress and inflammatory injury. Moreover, polyphenols have been reported to promote cognitive functions. Biotransformation of polyphenols is needed to obtain metabolites active in brain and it occurs through their processing by gut microbiota. Polyphenols metabolites could directly act as neurotransmitters crossing the blood-brain barrier or indirectly by modulating the cerebrovascular system. The microbiota-gut-brain axis is considered a neuroendocrine system that acts bidirectionally and plays an important role in stress responses. The metabolites produced by microbiota metabolism can modulate gut bacterial composition and brain biochemistry acting as neurotransmitters in the central nervous system. Gut microbiota composition can be influenced by dietary ingestion of natural bioactive molecules such as probiotics, prebiotics and polyphenol. Microbiota composition can be altered by dietary changes and gastrointestinal dysfunctions are observed in neurodegenerative diseases. In addition, several pieces of evidence support the idea that alterations in gut microbiota and enteric neuroimmune system could contribute to onset and progression of these age-related disorders. The impact of polyphenols on microbiota composition strengthens the idea that maintaining a healthy microbiome by modulating diet is essential for having a healthy brain across the lifespan. Moreover, it is emerging that they could be used as novel therapeutics to prevent brain from neurodegeneration.
Audience Academic
Author Crispi, Stefania
Filosa, Stefania
Di Meo, Francesco
AuthorAffiliation Institute of Biosciences and Bioresources, National Research Council, National Research Council, via P. Castellino, Naples, Italy;Istituto di Ricovero e Cura a Carattere Scientifico Neuromed, Pozzilli, Italy%Institute of Biosciences and Bioresources, National Research Council, National Research Council, via P. Castellino, Naples, Italy
AuthorAffiliation_xml – name: Institute of Biosciences and Bioresources, National Research Council, National Research Council, via P. Castellino, Naples, Italy;Istituto di Ricovero e Cura a Carattere Scientifico Neuromed, Pozzilli, Italy%Institute of Biosciences and Bioresources, National Research Council, National Research Council, via P. Castellino, Naples, Italy
– name: 2 Istituto di Ricovero e Cura a Carattere Scientifico Neuromed, Pozzilli, Italy
– name: 1 Institute of Biosciences and Bioresources, National Research Council, via P. Castellino, Naples, Italy
Author_xml – sequence: 1
  givenname: Stefania
  surname: Filosa
  fullname: Filosa, Stefania
  organization: Institute of Biosciences and Bioresources, National Research Council, via P. Castellino, Naples; Istituto di Ricovero e Cura a Carattere Scientifico Neuromed, Pozzilli
– sequence: 2
  givenname: Francesco
  surname: Di Meo
  fullname: Di Meo, Francesco
  organization: Institute of Biosciences and Bioresources, National Research Council, via P. Castellino, Naples
– sequence: 3
  givenname: Stefania
  surname: Crispi
  fullname: Crispi, Stefania
  organization: Institute of Biosciences and Bioresources, National Research Council, via P. Castellino, Naples
BackLink https://www.ncbi.nlm.nih.gov/pubmed/30323120$$D View this record in MEDLINE/PubMed
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Issue 12
Keywords polyphenols
neurotransmitters
metagenomic
neurodegeneration
prebiotics
gut-microbiota
gut-brain axis
probiotics
Language English
License http://creativecommons.org/licenses/by-nc-sa/4.0
This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
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Author contributions: Manuscript conception: SC; manuscript writing and revising: SF, FDM and SC; literature collection and figure design: FDM.
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PublicationTitle Neural regeneration research
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Institute of Biosciences and Bioresources, National Research Council, National Research Council, via P. Castellino, Naples, Italy
Istituto di Ricovero e Cura a Carattere Scientifico Neuromed, Pozzilli, Italy%Institute of Biosciences and Bioresources, National Research Council, National Research Council, via P. Castellino, Naples, Italy
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Snippet Increasing evidence suggests that food ingested polyphenols can have beneficial effects in neuronal protection acting against oxidative stress and inflammatory...
Increasing evidence suggests that food ingested polyphenols can have beneficial effects in neuronal protec-tion acting against oxidative stress and...
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SubjectTerms Animal cognition
Antioxidants
Bacteria
Bioavailability
Biological activity
Blood-brain barrier
Enzymes
Gut microbiota
Homeostasis
Metabolism
Metabolites
Microbiota
Microbiota (Symbiotic organisms)
Nervous system
Neurodegeneration
Organic chemicals
Pathogens
Polyphenols
polyphenols; gut-microbiota; gut-brain axis; metagenomic; neurodegeneration; neurotransmitters; prebiotics; probiotics
Prebiotics
Probiotics
Review
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Title Polyphenols-gut microbiota interplay and brain neuromodulation
URI http://www.nrronline.org/article.asp?issn=1673-5374;year=2018;volume=13;issue=12;spage=2055;epage=2059;aulast=Filosa;type=0
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