Host-microbial interactions in patients with chronic rhinosinusitis

• Published in: Journal of allergy and clinical immunology Vol. 133; no. 3; pp. 640 - 653.e4
• Main Author: Hamilos, Daniel L.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.03.2014; Elsevier; Elsevier Limited; American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc
• Subjects: Allergy and Immunology; antimicrobial; Asthma; Bacteria; biofilm; Biofilms; Biological and medical sciences; Chronic Disease; Chronic rhinosinusitis; Cytokines; Epithelium - physiology; Fundamental and applied biological sciences. Psychology; Fundamental immunology; host; Host-Pathogen Interactions; Humans; immunity; Immunity, Innate; Immunopathology; Infections - complications; innate; Ligands; Medical sciences; microbial; Mucociliary Clearance; Non tumoral diseases; Otorhinolaryngology. Stomatology; Proteins; Pseudomonas aeruginosa; Rhinitis - etiology; Rhinitis - immunology; Rhinitis - microbiology; Rodents; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Sinuses; Sinusitis - etiology; Sinusitis - immunology; Sinusitis - microbiology; Streptococcus infections; Studies; Th2 Cells - immunology; Toll-Like Receptors - physiology; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology; Viral infections; Viruses; Cp110; antimicrobial; NO; NP; Chronic rhinosinusitis; CRS; PLUNC; IESA; CRSwNP; IBD; immunity; CRSsNP; DMBT1; MBL; biofilm; host; LBP; TLR; CD; NOD; innate; hBD; microbial; EMCRS; CSLM; PCD; SEB; SP-D; SLPI; SP-A; AFRS; FISH; PNEC; BPI; SEM; HC; IL-22R; TEM; Confocal scanning laser microscopy; Human β-defensin; Chronic rhinosinusitis with nasal polyposis; Primary ciliary dyskinesia; Cultured primary nasal epithelial cell; Fluorescence in situ hybridization; Toll-like receptor; Bactericidal/permeability-increasing protein; Scanning electron microscopy; Inflammatory bowel disease; Crohn disease; Nitric oxide; Deleted in malignant brain tumor 1; Intraepithelial Staphylococcus aureus; LPS-binding protein; Nasal polyp; IL-22 receptor; Allergic fungal rhinosinusitis; Mannose-binding lectin; Healthy control subject; Secretory leukocyte proteinase inhibitor; Eosinophilic mucin chronic rhinosinusitis; Centrosomal protein 110; Palate lung and nasal epithelium clone; Surfactant protein A; Chronic rhinosinusitis without nasal polyps; Surfactant protein D; Transmission electron microscopy; Nucleotide-binding oligomerization domain; Staphylococcal enterotoxin B; Human; Immunopathology; Nose disease; Rhinitis; Immunity; Antimicrobial agent; Sinusitis; Chronic; Immunology; Biofilm; ENT disease; Paranasal sinus disease

There has been considerable investigation of host-microbial interactions in patients with chronic rhinosinusitis (CRS) in hopes of elucidating mechanisms of disease and better treatment. Most attention has been paid to bacterial infection and potential underlying defects in innate immunity. Bacteria...