Evidence for an association between KIBRA and late-onset Alzheimer's disease

• Published in: Neurobiology of aging Vol. 31; no. 6; pp. 901 - 909
• Main Authors: Corneveaux, Jason J., Liang, Winnie S., Reiman, Eric M., Webster, Jennifer A., Myers, Amanda J., Zismann, Victoria L., Joshipura, Keta D., Pearson, John V., Hu-Lince, Diane, Craig, David W., Coon, Keith D., Dunckley, Travis, Bandy, Daniel, Lee, Wendy, Chen, Kewei, Beach, Thomas G., Mastroeni, Diego, Grover, Andrew, Ravid, Rivka, Sando, Sigrid B., Aasly, Jan O., Heun, Reinhard, Jessen, Frank, Kölsch, Heike, Rogers, Joseph, Hutton, Michael L., Melquist, Stacey, Petersen, Ron C., Alexander, Gene E., Caselli, Richard J., Papassotiropoulos, Andreas, Stephan, Dietrich A., Huentelman, Matthew J.
• Format: Journal Article
• Language: English
• Published: London Elsevier Inc 01.06.2010; Elsevier
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - complications; Alzheimer Disease - diagnostic imaging; Alzheimer Disease - genetics; Alzheimer Disease - pathology; Apolipoproteins E - genetics; Biological and medical sciences; Brain - diagnostic imaging; Brain - enzymology; Brain - pathology; Brain Mapping; Cognition Disorders - etiology; Cognition Disorders - genetics; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Development. Senescence. Regeneration. Transplantation; Expression profiling; Female; Fundamental and applied biological sciences. Psychology; Gene Expression Profiling - methods; Genetic Predisposition to Disease; Genetics; Genome-Wide Association Study - methods; Genotype; Glial Fibrillary Acidic Protein - metabolism; Humans; Imaging; Internal Medicine; Intracellular Signaling Peptides and Proteins; Male; Medical sciences; Memory; Neurology; Neurons - metabolism; Neurons - pathology; Neuropsychological Tests; Oligonucleotide Array Sequence Analysis - methods; Phosphoproteins; Polymorphism, Single Nucleotide - genetics; Positron-Emission Tomography - methods; Proteins - genetics; Vertebrates: nervous system and sense organs; Genetics; Expression profiling; Imaging; Memory; Nervous system diseases; Senescence; Alzheimer disease; Central nervous system disease; Degenerative disease; Cerebral disorder

We recently reported evidence for an association between the individual variation in normal human episodic memory and a common variant of the KIBRA gene, KIBRA rs17070145 (T-allele). Since memory impairment is a cardinal clinical feature of Alzheimer's disease (AD), we investigated the possibil...