The ALPK1 pathway drives the inflammatory response to Campylobacter jejuni in human intestinal epithelial cells

• Published in: PLoS pathogens Vol. 17; no. 8; p. e1009787
• Main Authors: Cui, Jiannan, Duizer, Coco, Bouwman, Lieneke I., van Rooijen, Kristel S., Voogdt, Carlos G. P., van Putten, Jos P. M., de Zoete, Marcel R.
• Format: Journal Article
• Language: English
• Published: San Francisco, CA USA Public Library of Science 02.08.2021; Public Library of Science (PLoS)
• Subjects: Biology and Life Sciences; Campylobacter infections; Cellular signal transduction; Colorectal diseases; Complications and side effects; Development and progression; Epithelial cells; Gastrointestinal diseases; Health aspects; Inflammation; Medicine and Health Sciences; Physical Sciences; Protein kinases; Netherlands

The Gram-negative bacterium Campylobacter jejuni is a major cause of foodborne disease in humans. After infection, C . jejuni rapidly colonizes the mucus layer of the small and large intestine and induces a potent pro-inflammatory response characterized by the production of a large repertoire of cyt...