Patients with severe factor XI deficiency have a reduced incidence of deep-vein thrombosis

• Published in: Thrombosis and haemostasis Vol. 105; no. 2; p. 269
• Main Authors: Salomon, Ophira, Steinberg, David M, Zucker, Michal, Varon, David, Zivelin, Ariella, Seligsohn, Uri
• Format: Journal Article
• Language: English
• Published: Germany 01.02.2011
• Subjects: Adult; Aged; Aged, 80 and over; Case-Control Studies; Factor XI Deficiency - epidemiology; Factor XI Deficiency - genetics; Female; Genetic Predisposition to Disease; Hemostasis - genetics; Humans; Incidence; Israel - epidemiology; Male; Middle Aged; Phenotype; Polymorphism, Genetic; Risk Assessment; Risk Factors; Severity of Illness Index; Venous Thrombosis - epidemiology; Venous Thrombosis - prevention & control; Young Adult; Israel

Factor XI (FXI) plays a dual role in haemostasis and thrombosis. It contributes to thrombin generation and promotes inhibition of fibrinolysis. Severe FXI deficiency was shown to confer protection against arterial and venous thrombosis in animal models without compromising haemostasis. We have previ...