A randomised pilot trial of the anti-von Willebrand factor aptamer ARC1779 in patients with type 2b von Willebrand disease - Jilma, Bernd; Paulinska, Petra; Jilma-Stohlawetz, Petra; Gilbert, James C; Hutabarat, Renta; Knöbl, Paul (Thrombosis and haemostasis, 2010)
Keywords: Adult; Aged; Aptamers, Nucleotide - administration & dosage; Aptamers, Nucleotide - adverse effects; Aptamers, Nucleotide - pharmacokinetics; Aptamers, Nucleotide - therapeutic use; Austria; Binding Sites; Deamino Arginine Vasopressin - administration & dosage; Deamino Arginine Vasopressin - adverse effects; Double-Blind Method; Factor VIII - metabolism; Female; Hemostatics - administration & dosage; Hemostatics - adverse effects; Hemostatics - pharmacokinetics; Hemostatics - therapeutic use; Humans; Infusions, Intravenous; Male; Middle Aged; Partial Thromboplastin Time; Pilot Projects; Platelet Count; Platelet Function Tests; Protein Multimerization; Thrombocytopenia - blood; Thrombocytopenia - chemically induced; Time Factors; Treatment Outcome; von Willebrand Disease, Type 2 - blood; von Willebrand Disease, Type 2 - drug therapy; von Willebrand Factor - antagonists & inhibitors; von Willebrand Factor - metabolism; Austria