Enhanced innate type 2 immune response in peripheral blood from patients with asthma

• Published in: Journal of allergy and clinical immunology Vol. 134; no. 3; pp. 671 - 678.e4
• Main Authors: Bartemes, Kathleen R., Kephart, Gail M., Fox, Stephanie J., Kita, Hirohito
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.09.2014; Elsevier; Elsevier Limited
• Subjects: Allergies; allergy; Allergy and Immunology; Asthma; Asthma - diagnosis; Asthma - immunology; Biological and medical sciences; Blood Circulation; Cell Differentiation; Cell Separation; Cells, Cultured; Chlorophyll; Chronic obstructive pulmonary disease, asthma; Female; Flow Cytometry; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Humans; IL-13; IL-25; IL-33; IL-5; ILC2; Immune system; Immunity, Innate; Immunopathology; innate immunity; Interleukin-7 Receptor alpha Subunit - metabolism; Interleukins - immunology; Lymphocytes - immunology; Male; Medical sciences; Middle Aged; Pneumology; Receptors, Immunologic - metabolism; Receptors, Prostaglandin - metabolism; Rhinitis, Allergic - diagnosis; Rhinitis, Allergic - immunology; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Th2 Cells - immunology; AA; TSLP; IL-5; allergy; ILC2s; IL-25; asthma; IL-13; IL-33; ILC2; Lin; AR; FITC; innate immunity; SNP; HC; Fluorescein isothiocyanate; Healthy control; Lineage-negative; Allergic rhinitis; Allergic asthma; Group 2 innate lymphoid cells; Lineage-positive; Thymic stromal lymphopoietin; Single nucleotide polymorphism; Human; Lung disease; Allergy; Immunopathology; Immune response; Respiratory disease; Cytokine; Natural immunity; Interleukin 13; Blood; Asthma; Immunology; Interleukin 5; Bronchus disease; Obstructive pulmonary disease

In mice, group 2 innate lymphoid cells (ILC2s) likely mediate helminth immunity, inflammation, and tissue repair and remodeling. However, the involvement of ILC2s in human diseases, such as asthma, is not well understood. The goals of this study were to investigate whether peripheral blood specimens...