Changes in trachoma indicators in Kiribati with two rounds of azithromycin mass drug administration, measured in serial population-based surveys

Baseline mapping in the two major population centers of Kiribati showed that trachoma was a public health problem in need of programmatic interventions. After conducting two annual rounds of antibiotic mass drug administration (MDA), Kiribati undertook trachoma impact surveys in 2019, using standard...

Full description

Saved in:
Bibliographic Details
Published inPLoS neglected tropical diseases Vol. 17; no. 7; p. e0011441
Main Authors Goodhew, E Brook, Taoaba, Raebwebwe, Harding-Esch, Emma M, Gwyn, Sarah E, Bakhtiari, Ana, Butcher, Robert, Cama, Anasaini, Guagliardo, Sarah Anne J, Jimenez, Cristina, Mpyet, Caleb D, Tun, Kab, Wickens, Karana, Solomon, Anthony W, Martin, Diana L, Tekeraoi, Rabebe
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 07.07.2023
Public Library of Science (PLoS)
Subjects
Online AccessGet full text

Cover

Loading…
Abstract Baseline mapping in the two major population centers of Kiribati showed that trachoma was a public health problem in need of programmatic interventions. After conducting two annual rounds of antibiotic mass drug administration (MDA), Kiribati undertook trachoma impact surveys in 2019, using standardized two-stage cluster surveys in the evaluation units of Kiritimati Island and Tarawa. In Kiritimati, 516 households were visited and in Tarawa, 772 households were visited. Nearly all households had a drinking water source and access to an improved latrine. The prevalence of trachomatous trichiasis remained above the elimination threshold (0.2% in ≥15-year-olds) and was virtually unchanged from baseline. The prevalence of trachomatous inflammation-follicular (TF) in 1-9-year-olds decreased by approximately 40% from baseline in both evaluation units but remained above the 5% TF prevalence threshold for stopping MDA. TF prevalence at impact survey was 11.5% in Kiritimati and 17.9% in Tarawa. Infection prevalence in 1-9-year-olds by PCR was 0.96% in Kiritimati and 3.3% in Tarawa. Using a multiplex bead assay to measure antibodies to the C. trachomatis antigen Pgp3, seroprevalence in 1-9-year-olds was 30.2% in Kiritimati and 31.4% in Tarawa. The seroconversion rate, in seroconversion events/100 children/year, was 9.0 in Kiritimati and 9.2 in Tarawa. Seroprevalence and seroconversion rates were both assessed by four different assays, with strong agreement between tests. These results show that, despite decreases in indicators associated with infection at impact survey, trachoma remains a public health problem in Kiribati, and provide additional information about changes in serological indicators after MDA.
AbstractList Baseline mapping in the two major population centers of Kiribati showed that trachoma was a public health problem in need of programmatic interventions. After conducting two annual rounds of antibiotic mass drug administration (MDA), Kiribati undertook trachoma impact surveys in 2019, using standardized two-stage cluster surveys in the evaluation units of Kiritimati Island and Tarawa. In Kiritimati, 516 households were visited and in Tarawa, 772 households were visited. Nearly all households had a drinking water source and access to an improved latrine. The prevalence of trachomatous trichiasis remained above the elimination threshold (0.2% in ≥15-year-olds) and was virtually unchanged from baseline. The prevalence of trachomatous inflammation—follicular (TF) in 1–9-year-olds decreased by approximately 40% from baseline in both evaluation units but remained above the 5% TF prevalence threshold for stopping MDA. TF prevalence at impact survey was 11.5% in Kiritimati and 17.9% in Tarawa. Infection prevalence in 1–9-year-olds by PCR was 0.96% in Kiritimati and 3.3% in Tarawa. Using a multiplex bead assay to measure antibodies to the C . trachomatis antigen Pgp3, seroprevalence in 1–9-year-olds was 30.2% in Kiritimati and 31.4% in Tarawa. The seroconversion rate, in seroconversion events/100 children/year, was 9.0 in Kiritimati and 9.2 in Tarawa. Seroprevalence and seroconversion rates were both assessed by four different assays, with strong agreement between tests. These results show that, despite decreases in indicators associated with infection at impact survey, trachoma remains a public health problem in Kiribati, and provide additional information about changes in serological indicators after MDA.
Baseline mapping in the two major population centers of Kiribati showed that trachoma was a public health problem in need of programmatic interventions. After conducting two annual rounds of antibiotic mass drug administration (MDA), Kiribati undertook trachoma impact surveys in 2019, using standardized two-stage cluster surveys in the evaluation units of Kiritimati Island and Tarawa. In Kiritimati, 516 households were visited and in Tarawa, 772 households were visited. Nearly all households had a drinking water source and access to an improved latrine. The prevalence of trachomatous trichiasis remained above the elimination threshold (0.2% in [greater than or equal to]15-year-olds) and was virtually unchanged from baseline. The prevalence of trachomatous inflammation-follicular (TF) in 1-9-year-olds decreased by approximately 40% from baseline in both evaluation units but remained above the 5% TF prevalence threshold for stopping MDA. TF prevalence at impact survey was 11.5% in Kiritimati and 17.9% in Tarawa. Infection prevalence in 1-9-year-olds by PCR was 0.96% in Kiritimati and 3.3% in Tarawa. Using a multiplex bead assay to measure antibodies to the C. trachomatis antigen Pgp3, seroprevalence in 1-9-year-olds was 30.2% in Kiritimati and 31.4% in Tarawa. The seroconversion rate, in seroconversion events/100 children/year, was 9.0 in Kiritimati and 9.2 in Tarawa. Seroprevalence and seroconversion rates were both assessed by four different assays, with strong agreement between tests. These results show that, despite decreases in indicators associated with infection at impact survey, trachoma remains a public health problem in Kiribati, and provide additional information about changes in serological indicators after MDA.
Baseline mapping in the two major population centers of Kiribati showed that trachoma was a public health problem in need of programmatic interventions. After conducting two annual rounds of antibiotic mass drug administration (MDA), Kiribati undertook trachoma impact surveys in 2019, using standardized two-stage cluster surveys in the evaluation units of Kiritimati Island and Tarawa. In Kiritimati, 516 households were visited and in Tarawa, 772 households were visited. Nearly all households had a drinking water source and access to an improved latrine. The prevalence of trachomatous trichiasis remained above the elimination threshold (0.2% in ≥15-year-olds) and was virtually unchanged from baseline. The prevalence of trachomatous inflammation-follicular (TF) in 1-9-year-olds decreased by approximately 40% from baseline in both evaluation units but remained above the 5% TF prevalence threshold for stopping MDA. TF prevalence at impact survey was 11.5% in Kiritimati and 17.9% in Tarawa. Infection prevalence in 1-9-year-olds by PCR was 0.96% in Kiritimati and 3.3% in Tarawa. Using a multiplex bead assay to measure antibodies to the C. trachomatis antigen Pgp3, seroprevalence in 1-9-year-olds was 30.2% in Kiritimati and 31.4% in Tarawa. The seroconversion rate, in seroconversion events/100 children/year, was 9.0 in Kiritimati and 9.2 in Tarawa. Seroprevalence and seroconversion rates were both assessed by four different assays, with strong agreement between tests. These results show that, despite decreases in indicators associated with infection at impact survey, trachoma remains a public health problem in Kiribati, and provide additional information about changes in serological indicators after MDA.
Baseline mapping in the two major population centers of Kiribati showed that trachoma was a public health problem in need of programmatic interventions. After conducting two annual rounds of antibiotic mass drug administration (MDA), Kiribati undertook trachoma impact surveys in 2019, using standardized two-stage cluster surveys in the evaluation units of Kiritimati Island and Tarawa. In Kiritimati, 516 households were visited and in Tarawa, 772 households were visited. Nearly all households had a drinking water source and access to an improved latrine. The prevalence of trachomatous trichiasis remained above the elimination threshold (0.2% in ≥15-year-olds) and was virtually unchanged from baseline. The prevalence of trachomatous inflammation—follicular (TF) in 1–9-year-olds decreased by approximately 40% from baseline in both evaluation units but remained above the 5% TF prevalence threshold for stopping MDA. TF prevalence at impact survey was 11.5% in Kiritimati and 17.9% in Tarawa. Infection prevalence in 1–9-year-olds by PCR was 0.96% in Kiritimati and 3.3% in Tarawa. Using a multiplex bead assay to measure antibodies to the C . trachomatis antigen Pgp3, seroprevalence in 1–9-year-olds was 30.2% in Kiritimati and 31.4% in Tarawa. The seroconversion rate, in seroconversion events/100 children/year, was 9.0 in Kiritimati and 9.2 in Tarawa. Seroprevalence and seroconversion rates were both assessed by four different assays, with strong agreement between tests. These results show that, despite decreases in indicators associated with infection at impact survey, trachoma remains a public health problem in Kiribati, and provide additional information about changes in serological indicators after MDA. This study compares different indicators for the eye disease trachoma before and after two annual rounds of mass azithromycin treatment of affected communities of Kiribati. We saw decreases in the proportion of children with the sign TF (trachomatous inflammation—follicular) that is used by trachoma programs to make decisions about starting and stopping mass treatment, but these decreases were not sufficient to make the decision to stop. We also saw decreases in infection and antibody levels after treatment. The study provides important public health information to Kiribati trachoma programs, but also adds to the growing body of evidence to guide the use of alternative indicators–infection and antibody–to support these programs. Measuring antibody levels in communities over time helps us understand how antibody levels change as community infection prevalence decreases. Understanding antibody dynamics over time can help us better estimate antibody-based thresholds for surveillance after elimination of trachoma as a public health problem.
Audience Academic
Author Wickens, Karana
Solomon, Anthony W
Cama, Anasaini
Harding-Esch, Emma M
Mpyet, Caleb D
Butcher, Robert
Tun, Kab
Taoaba, Raebwebwe
Goodhew, E Brook
Bakhtiari, Ana
Gwyn, Sarah E
Martin, Diana L
Tekeraoi, Rabebe
Jimenez, Cristina
Guagliardo, Sarah Anne J
AuthorAffiliation 8 Department of Ophthalmology, College of Health Sciences, University of Jos; Jos, Nigeria, and Sightsavers, Nigeria Country Office, Kaduna, Nigeria
10 Department of Control of Neglected Tropical Diseases, World Health Organization, Geneva, Switzerland
6 The Fred Hollows Foundation, Melbourne, Australia
1 VAAS Contractors, Atlanta Georgia
4 Centers for Disease Control and Prevention, Atlanta Georgia
RTI International, UNITED REPUBLIC OF TANZANIA
2 Ministry of Health and Medical Services, South Tarawa, Kiribati
7 Sightsavers International, London United Kingdom
3 Clinical Research Department, London School of Hygiene & Tropical Medicine, London, United Kingdom
5 International Trachoma Initiative, Task Force for Global Health, Atlanta, Georgia
9 Oak Ridge Institute for Science and Education, Oak Ridge, Tennessee
AuthorAffiliation_xml – name: RTI International, UNITED REPUBLIC OF TANZANIA
– name: 3 Clinical Research Department, London School of Hygiene & Tropical Medicine, London, United Kingdom
– name: 8 Department of Ophthalmology, College of Health Sciences, University of Jos; Jos, Nigeria, and Sightsavers, Nigeria Country Office, Kaduna, Nigeria
– name: 2 Ministry of Health and Medical Services, South Tarawa, Kiribati
– name: 5 International Trachoma Initiative, Task Force for Global Health, Atlanta, Georgia
– name: 9 Oak Ridge Institute for Science and Education, Oak Ridge, Tennessee
– name: 1 VAAS Contractors, Atlanta Georgia
– name: 6 The Fred Hollows Foundation, Melbourne, Australia
– name: 4 Centers for Disease Control and Prevention, Atlanta Georgia
– name: 10 Department of Control of Neglected Tropical Diseases, World Health Organization, Geneva, Switzerland
– name: 7 Sightsavers International, London United Kingdom
Author_xml – sequence: 1
  givenname: E Brook
  surname: Goodhew
  fullname: Goodhew, E Brook
  organization: VAAS Contractors, Atlanta Georgia
– sequence: 2
  givenname: Raebwebwe
  surname: Taoaba
  fullname: Taoaba, Raebwebwe
  organization: Ministry of Health and Medical Services, South Tarawa, Kiribati
– sequence: 3
  givenname: Emma M
  surname: Harding-Esch
  fullname: Harding-Esch, Emma M
  organization: Clinical Research Department, London School of Hygiene & Tropical Medicine, London, United Kingdom
– sequence: 4
  givenname: Sarah E
  surname: Gwyn
  fullname: Gwyn, Sarah E
  organization: Centers for Disease Control and Prevention, Atlanta Georgia
– sequence: 5
  givenname: Ana
  surname: Bakhtiari
  fullname: Bakhtiari, Ana
  organization: International Trachoma Initiative, Task Force for Global Health, Atlanta, Georgia
– sequence: 6
  givenname: Robert
  surname: Butcher
  fullname: Butcher, Robert
  organization: Clinical Research Department, London School of Hygiene & Tropical Medicine, London, United Kingdom
– sequence: 7
  givenname: Anasaini
  surname: Cama
  fullname: Cama, Anasaini
  organization: The Fred Hollows Foundation, Melbourne, Australia
– sequence: 8
  givenname: Sarah Anne J
  surname: Guagliardo
  fullname: Guagliardo, Sarah Anne J
  organization: Centers for Disease Control and Prevention, Atlanta Georgia
– sequence: 9
  givenname: Cristina
  surname: Jimenez
  fullname: Jimenez, Cristina
  organization: Sightsavers International, London United Kingdom
– sequence: 10
  givenname: Caleb D
  surname: Mpyet
  fullname: Mpyet, Caleb D
  organization: Department of Ophthalmology, College of Health Sciences, University of Jos; Jos, Nigeria, and Sightsavers, Nigeria Country Office, Kaduna, Nigeria
– sequence: 11
  givenname: Kab
  surname: Tun
  fullname: Tun, Kab
  organization: Ministry of Health and Medical Services, South Tarawa, Kiribati
– sequence: 12
  givenname: Karana
  surname: Wickens
  fullname: Wickens, Karana
  organization: Oak Ridge Institute for Science and Education, Oak Ridge, Tennessee
– sequence: 13
  givenname: Anthony W
  surname: Solomon
  fullname: Solomon, Anthony W
  organization: Department of Control of Neglected Tropical Diseases, World Health Organization, Geneva, Switzerland
– sequence: 14
  givenname: Diana L
  orcidid: 0000-0001-9417-5562
  surname: Martin
  fullname: Martin, Diana L
  organization: Centers for Disease Control and Prevention, Atlanta Georgia
– sequence: 15
  givenname: Rabebe
  surname: Tekeraoi
  fullname: Tekeraoi, Rabebe
  organization: Ministry of Health and Medical Services, South Tarawa, Kiribati
BackLink https://www.ncbi.nlm.nih.gov/pubmed/37418501$$D View this record in MEDLINE/PubMed
https://www.osti.gov/servlets/purl/2425603$$D View this record in Osti.gov
BookMark eNptk9tu1DAQhiNURA_wBggikBAX7GLHduJcoariUFGJG7i2Js5k41ViL7bTqjwFj4zT3Va7qPKFrZlvftu_Zk6zI-ssZtlLSpaUVfTj2k3ewrDc2NguCaGUc_okO6E1E4uiYuJo73ycnYawJkTUQtJn2TGrOJWC0JPs70UPdoUhNzaPHnTvRkjn1miIzt-FvxtvGogmvzGxz-ONy72bbBty1-XwJ8W8G291AkcIIW_9tMqhHY01IQlG4-yHfEQIk8d2lgvoDQz5xm2m4S69aCCkVAKu8TY8z552MAR8sdvPsl9fPv-8-La4-vH18uL8aqFLUcQF7wgpkSEpAGVBZcmI0Fhq0kgsoa06BhS1RK1bJinrmlJyRmXB26opEQg7y15vdTeDC2pnZlCFFLSuOK9n4nJLtA7WauPNCP5WOTDqLuD8SoGPRg-oGNZIyopx4Jy3jMumLLCWlax0U1OEpPVpd9vUjNhqtMmb4UD0MGNNr1buWlHChOCsTgpvtgouRKOCNhF1r521qKMqeCFKwhL0fneNd78nDFGNJmgcBrDopvl3TKR-qMSs9_Y_9HEPdtQK0jeN7dzcJLOoOp9VeFlXRaKWj1BptTia9EbsTIofFLzbK-gRhtgHN0xzO4RDkG9B7V0IHrsHyyhR8xjcv1rNY6B2Y5DKXu3b_VB03_fsH1IHCE4
CitedBy_id crossref_primary_10_1038_s41598_024_57652_4
Cites_doi 10.1186/s12879-019-3935-1
10.1371/journal.pntd.0001873
10.1371/journal.pntd.0005230
10.1056/NEJMoa040979
10.1038/s41598-021-86639-8
10.1186/s13071-019-3743-x
10.1073/pnas.0408725102
10.1371/journal.pntd.0008316
10.1038/s41598-018-21127-0
10.1186/1471-2334-14-216
10.1371/journal.pntd.0000376
10.4269/ajtmh.20-0777
10.1080/09286586.2018.1500616
10.1167/iovs.06-0625
10.4269/ajtmh.17-0292
10.1038/s41598-018-22708-9
10.2471/BLT.19.248708
10.4269/ajtmh.21-0541
10.1128/JCM.00519-13
10.1016/j.jinf.2020.01.015
10.3109/09286586.2015.1037401
10.1038/s41467-018-07852-0
10.4269/ajtmh.17-0102
10.1371/journal.pntd.0000462
10.1371/journal.pntd.0005863
ContentType Journal Article
Copyright Copyright: This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.
COPYRIGHT 2023 Public Library of Science
This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication: https://creativecommons.org/publicdomain/zero/1.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml – notice: Copyright: This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.
– notice: COPYRIGHT 2023 Public Library of Science
– notice: This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication: https://creativecommons.org/publicdomain/zero/1.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
CorporateAuthor Oak Ridge Institute for Science and Education (ORISE), Oak Ridge, TN (United States)
CorporateAuthor_xml – sequence: 0
  name: Oak Ridge Institute for Science and Education (ORISE), Oak Ridge, TN (United States)
DBID NPM
AAYXX
CITATION
3V.
7QL
7SS
7T2
7T7
7U9
7X7
7XB
88E
8C1
8FD
8FI
8FJ
8FK
ABUWG
AFKRA
AZQEC
BENPR
C1K
CCPQU
DWQXO
F1W
FR3
FYUFA
GHDGH
H94
H95
H97
K9.
L.G
M0S
M1P
M7N
P64
PIMPY
PQEST
PQQKQ
PQUKI
7X8
OIOZB
OTOTI
5PM
DOA
DOI 10.1371/journal.pntd.0011441
DatabaseName PubMed
CrossRef
ProQuest Central (Corporate)
Bacteriology Abstracts (Microbiology B)
Entomology Abstracts (Full archive)
Health and Safety Science Abstracts (Full archive)
Industrial and Applied Microbiology Abstracts (Microbiology A)
Virology and AIDS Abstracts
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
Public Health Database (Proquest)
Technology Research Database
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central
ProQuest Central Essentials
ProQuest Central
Environmental Sciences and Pollution Management
ProQuest One Community College
ProQuest Central Korea
ASFA: Aquatic Sciences and Fisheries Abstracts
Engineering Research Database
Health Research Premium Collection
Health Research Premium Collection (Alumni)
AIDS and Cancer Research Abstracts
Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources
Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality
ProQuest Health & Medical Complete (Alumni)
Aquatic Science & Fisheries Abstracts (ASFA) Professional
Health & Medical Collection (Alumni Edition)
PML(ProQuest Medical Library)
Algology Mycology and Protozoology Abstracts (Microbiology C)
Biotechnology and BioEngineering Abstracts
Publicly Available Content Database
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
MEDLINE - Academic
OSTI.GOV - Hybrid
OSTI.GOV
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle PubMed
CrossRef
Publicly Available Content Database
Aquatic Science & Fisheries Abstracts (ASFA) Professional
Technology Research Database
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality
Environmental Sciences and Pollution Management
ProQuest Central
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Bacteriology Abstracts (Microbiology B)
Algology Mycology and Protozoology Abstracts (Microbiology C)
AIDS and Cancer Research Abstracts
Health & Safety Science Abstracts
Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources
Industrial and Applied Microbiology Abstracts (Microbiology A)
ProQuest Medical Library (Alumni)
ProQuest Public Health
Virology and AIDS Abstracts
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
Entomology Abstracts
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
ASFA: Aquatic Sciences and Fisheries Abstracts
Engineering Research Database
ProQuest One Academic
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList CrossRef



PubMed


Publicly Available Content Database

Database_xml – sequence: 1
  dbid: DOA
  name: Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Public Health
DocumentTitleAlternate Trachoma impact surveys in Kiribati including alternative indicators
EISSN 1935-2735
Editor Ngondi, Jeremiah M.
Editor_xml – sequence: 1
  givenname: Jeremiah M.
  surname: Ngondi
  fullname: Ngondi, Jeremiah M.
EndPage e0011441
ExternalDocumentID 2851974490
oai_doaj_org_article_3e9e06734a444d348b62e98787cb91ea
2425603
A759346972
10_1371_journal_pntd_0011441
37418501
Genre Journal Article
GeographicLocations Kiribati
Atlanta Georgia
United States--US
GeographicLocations_xml – name: Kiribati
– name: Atlanta Georgia
– name: United States--US
GrantInformation_xml – fundername: ;
– fundername: ;
  grantid: 1954-0
GroupedDBID ---
123
29O
2WC
3V.
53G
5VS
7X7
88E
8C1
8FI
8FJ
AAFWJ
ABDBF
ABUWG
ACGFO
ACIHN
ACPRK
ADBBV
AEAQA
AENEX
AFKRA
AFRAH
AHMBA
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AOIJS
BAWUL
BCNDV
BENPR
BPHCQ
BVXVI
BWKFM
CCPQU
CS3
DIK
DU5
E3Z
EAP
EAS
EBD
ECGQY
EMOBN
ESX
F5P
FPL
FYUFA
GROUPED_DOAJ
GX1
HMCUK
HYE
IAO
IHR
IHW
ITC
KQ8
M1P
M48
M~E
NPM
O5R
O5S
OK1
P2P
PGMZT
PIMPY
PQQKQ
PROAC
PSQYO
PV9
RNS
RPM
RZL
SV3
TR2
TUS
UKHRP
AAYXX
CITATION
AFPKN
7QL
7SS
7T2
7T7
7U9
7XB
8FD
8FK
AZQEC
C1K
DWQXO
F1W
FR3
H94
H95
H97
K9.
L.G
M7N
P64
PQEST
PQUKI
7X8
OIOZB
OTOTI
5PM
AAPBV
ABPTK
ID FETCH-LOGICAL-c652t-4f006e3e02ae82186305ce6c0b8e6ad7f3a1ec8eccd3813fb68431824d7b6ea03
IEDL.DBID RPM
ISSN 1935-2735
1935-2727
IngestDate Sun Oct 01 00:20:28 EDT 2023
Tue Oct 22 15:13:28 EDT 2024
Tue Sep 17 21:30:22 EDT 2024
Thu Dec 05 06:31:37 EST 2024
Fri Oct 25 08:10:28 EDT 2024
Fri Nov 08 21:36:26 EST 2024
Tue Nov 19 21:45:14 EST 2024
Tue Nov 12 23:50:14 EST 2024
Tue Aug 20 22:10:35 EDT 2024
Thu Nov 21 23:43:42 EST 2024
Wed Oct 16 00:39:53 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 7
Language English
License Copyright: This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.
This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.
Creative Commons CC0 public domain
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c652t-4f006e3e02ae82186305ce6c0b8e6ad7f3a1ec8eccd3813fb68431824d7b6ea03
Notes new_version
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
SC0014664
USDOE Office of Science (SC)
The authors report no competing interests to declare.
ORCID 0000-0001-9417-5562
0000000194175562
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10355439/
PMID 37418501
PQID 2851974490
PQPubID 1436337
ParticipantIDs plos_journals_2851974490
doaj_primary_oai_doaj_org_article_3e9e06734a444d348b62e98787cb91ea
pubmedcentral_primary_oai_pubmedcentral_nih_gov_10355439
osti_scitechconnect_2425603
proquest_miscellaneous_2835273759
proquest_journals_2851974490
gale_infotracmisc_A759346972
gale_infotracacademiconefile_A759346972
gale_healthsolutions_A759346972
crossref_primary_10_1371_journal_pntd_0011441
pubmed_primary_37418501
PublicationCentury 2000
PublicationDate 20230707
PublicationDateYYYYMMDD 2023-07-07
PublicationDate_xml – month: 7
  year: 2023
  text: 20230707
  day: 7
PublicationDecade 2020
PublicationPlace United States
PublicationPlace_xml – name: United States
– name: San Francisco
– name: San Francisco, CA USA
PublicationTitle PLoS neglected tropical diseases
PublicationTitleAlternate PLoS Negl Trop Dis
PublicationYear 2023
Publisher Public Library of Science
Public Library of Science (PLoS)
Publisher_xml – sequence: 0
  name: Public Library of Science
– name: Public Library of Science
– name: Public Library of Science (PLoS)
References S Gwyn (pntd.0011441.ref016) 2021; 11
DL Martin (pntd.0011441.ref011) 2020; 14
EB Goodhew (pntd.0011441.ref026) 2014; 14
CJ Drakeley (pntd.0011441.ref021) 2005; 102
AW Solomon (pntd.0011441.ref012) 2015; 22
SK West (pntd.0011441.ref025) 2018; 8
A Cama (pntd.0011441.ref008) 2017; 11
World Health Organization (pntd.0011441.ref003) 2020; 95
L Dize (pntd.0011441.ref019) 2013; 51
A Pinsent (pntd.0011441.ref022) 2018; 9
P Corran (pntd.0011441.ref020) 2007; 23
S Gwyn (pntd.0011441.ref031) 2017; 97
EB Goodhew (pntd.0011441.ref014) 2012; 6
AW Solomon (pntd.0011441.ref005) 2020; 98
SJ Migchelsen (pntd.0011441.ref018) 2017; 11
World Health Organization (pntd.0011441.ref001) 2022
ZM Solomon A (pntd.0011441.ref023) 2006
SK West (pntd.0011441.ref028) 2007; 48
AW Solomon (pntd.0011441.ref027) 2004; 351
World Health Organization (pntd.0011441.ref004) 2010
RE Wiegand (pntd.0011441.ref017) 2018; 8
SE Gwyn (pntd.0011441.ref024) 2018; 98
R Butcher (pntd.0011441.ref007) 2020; 80
EM Harding-Esch (pntd.0011441.ref030) 2019; 12
RM Flueckiger (pntd.0011441.ref006) 2019; 19
B Thylefors (pntd.0011441.ref002) 1987; 65
M Gambhir (pntd.0011441.ref010) 2009; 3
SD Nash (pntd.0011441.ref009) 2021; 104
AW Solomon (pntd.0011441.ref013) 2018; 25
S Gwyn (pntd.0011441.ref015) 2021; 105
T Lakew (pntd.0011441.ref029) 2009; 3
References_xml – volume: 19
  start-page: 364
  issue: 1
  year: 2019
  ident: pntd.0011441.ref006
  article-title: Understanding the spatial distribution of trichiasis and its association with trachomatous inflammation-follicular
  publication-title: BMC Infect Dis
  doi: 10.1186/s12879-019-3935-1
  contributor:
    fullname: RM Flueckiger
– volume: 6
  start-page: e1873
  issue: 11
  year: 2012
  ident: pntd.0011441.ref014
  article-title: CT694 and pgp3 as serological tools for monitoring trachoma programs
  publication-title: PLoS Negl Trop Dis
  doi: 10.1371/journal.pntd.0001873
  contributor:
    fullname: EB Goodhew
– volume: 11
  start-page: e0005230
  issue: 1
  year: 2017
  ident: pntd.0011441.ref018
  article-title: Defining Seropositivity Thresholds for Use in Trachoma Elimination Studies
  publication-title: PLoS Negl Trop Dis
  doi: 10.1371/journal.pntd.0005230
  contributor:
    fullname: SJ Migchelsen
– volume: 351
  start-page: 1962
  issue: 19
  year: 2004
  ident: pntd.0011441.ref027
  article-title: Mass treatment with single-dose azithromycin for trachoma
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa040979
  contributor:
    fullname: AW Solomon
– volume: 11
  start-page: 7225
  issue: 1
  year: 2021
  ident: pntd.0011441.ref016
  article-title: Comparison of platforms for testing antibodies to Chlamydia trachomatis antigens in the Democratic Republic of the Congo and Togo
  publication-title: Sci Rep
  doi: 10.1038/s41598-021-86639-8
  contributor:
    fullname: S Gwyn
– volume: 12
  start-page: 497
  issue: 1
  year: 2019
  ident: pntd.0011441.ref030
  article-title: Impact of a single round of mass drug administration with azithromycin on active trachoma and ocular Chlamydia trachomatis prevalence and circulating strains in The Gambia and Senegal
  publication-title: Parasit Vectors
  doi: 10.1186/s13071-019-3743-x
  contributor:
    fullname: EM Harding-Esch
– volume: 102
  start-page: 5108
  issue: 14
  year: 2005
  ident: pntd.0011441.ref021
  article-title: Estimating medium- and long-term trends in malaria transmission by using serological markers of malaria exposure
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.0408725102
  contributor:
    fullname: CJ Drakeley
– year: 2022
  ident: pntd.0011441.ref001
  article-title: WHO Alliance for the Global Elimination of Trachoma: progress report on elimination of trachoma, 2021
  publication-title: Weekly Epidemiological Record
  contributor:
    fullname: World Health Organization
– volume: 65
  start-page: 477
  issue: 4
  year: 1987
  ident: pntd.0011441.ref002
  article-title: A simple system for the assessment of trachoma and its complications
  publication-title: Bull World Health Organ
  contributor:
    fullname: B Thylefors
– volume: 14
  start-page: e0008316
  issue: 9
  year: 2020
  ident: pntd.0011441.ref011
  article-title: The use of serology for trachoma surveillance: Current status and priorities for future investigation
  publication-title: PLoS Negl Trop Dis
  doi: 10.1371/journal.pntd.0008316
  contributor:
    fullname: DL Martin
– volume: 8
  start-page: 3520
  issue: 1
  year: 2018
  ident: pntd.0011441.ref025
  article-title: Longitudinal change in the serology of antibodies to Chlamydia trachomatis pgp3 in children residing in a trachoma area
  publication-title: Sci Rep
  doi: 10.1038/s41598-018-21127-0
  contributor:
    fullname: SK West
– volume: 14
  start-page: 216
  year: 2014
  ident: pntd.0011441.ref026
  article-title: Longitudinal analysis of antibody responses to trachoma antigens before and after mass drug administration
  publication-title: BMC Infect Dis
  doi: 10.1186/1471-2334-14-216
  contributor:
    fullname: EB Goodhew
– volume: 3
  start-page: e376
  issue: 2
  year: 2009
  ident: pntd.0011441.ref029
  article-title: Reduction and return of infectious trachoma in severely affected communities in Ethiopia
  publication-title: PLoS Negl Trop Dis
  doi: 10.1371/journal.pntd.0000376
  contributor:
    fullname: T Lakew
– volume: 104
  start-page: 207
  issue: 1
  year: 2021
  ident: pntd.0011441.ref009
  article-title: Population-Based Prevalence of Chlamydia trachomatis Infection and Antibodies in Four Districts with Varying Levels of Trachoma Endemicity in Amhara, Ethiopia
  publication-title: Am J Trop Med Hyg
  doi: 10.4269/ajtmh.20-0777
  contributor:
    fullname: SD Nash
– volume: 25
  start-page: 399
  issue: 5–6
  year: 2018
  ident: pntd.0011441.ref013
  article-title: A diagnostic instrument to help field graders evaluate active trachoma
  publication-title: Ophthalmic Epidemiol
  doi: 10.1080/09286586.2018.1500616
  contributor:
    fullname: AW Solomon
– volume: 48
  start-page: 1492
  issue: 4
  year: 2007
  ident: pntd.0011441.ref028
  article-title: Trachoma and ocular Chlamydia trachomatis were not eliminated three years after two rounds of mass treatment in a trachoma hyperendemic village
  publication-title: Invest Ophthalmol Vis Sci
  doi: 10.1167/iovs.06-0625
  contributor:
    fullname: SK West
– volume: 97
  start-page: 1662
  issue: 6
  year: 2017
  ident: pntd.0011441.ref031
  article-title: Comparison of Platforms for Testing Antibody Responses against the Chlamydia trachomatis Antigen Pgp3
  publication-title: Am J Trop Med Hyg
  doi: 10.4269/ajtmh.17-0292
  contributor:
    fullname: S Gwyn
– volume: 8
  start-page: 4232
  issue: 1
  year: 2018
  ident: pntd.0011441.ref017
  article-title: Latent class modeling to compare testing platforms for detection of antibodies against the Chlamydia trachomatis antigen Pgp3
  publication-title: Sci Rep
  doi: 10.1038/s41598-018-22708-9
  contributor:
    fullname: RE Wiegand
– volume: 98
  start-page: 698
  issue: 10
  year: 2020
  ident: pntd.0011441.ref005
  article-title: The simplified trachoma grading system, amended
  publication-title: Bull World Health Organ
  doi: 10.2471/BLT.19.248708
  contributor:
    fullname: AW Solomon
– volume-title: Report of the 3rd Global Scientific Meeting on Trachoma
  year: 2010
  ident: pntd.0011441.ref004
  contributor:
    fullname: World Health Organization
– volume: 105
  start-page: 1362
  issue: 5
  year: 2021
  ident: pntd.0011441.ref015
  article-title: The Performance of Immunoassays to Measure Antibodies to the Chlamydia trachomatis Antigen Pgp3 in Different Epidemiological Settings for Trachoma
  publication-title: Am J Trop Med Hyg
  doi: 10.4269/ajtmh.21-0541
  contributor:
    fullname: S Gwyn
– volume: 51
  start-page: 1611
  issue: 5
  year: 2013
  ident: pntd.0011441.ref019
  article-title: Comparison of the Abbott m2000 RealTime CT assay and the Cepheid GeneXpert CT/NG assay to the Roche Amplicor CT assay for detection of Chlamydia trachomatis in ocular samples from Tanzania
  publication-title: J Clin Microbiol
  doi: 10.1128/JCM.00519-13
  contributor:
    fullname: L Dize
– volume-title: A Guide for Program Managers
  year: 2006
  ident: pntd.0011441.ref023
  contributor:
    fullname: ZM Solomon A
– volume: 80
  start-page: 454
  issue: 4
  year: 2020
  ident: pntd.0011441.ref007
  article-title: Ocular Chlamydia trachomatis infection, anti-Pgp3 antibodies and conjunctival scarring in Vanuatu and Tarawa, Kiribati before antibiotic treatment for trachoma
  publication-title: J Infect
  doi: 10.1016/j.jinf.2020.01.015
  contributor:
    fullname: R Butcher
– volume: 22
  start-page: 214
  issue: 3
  year: 2015
  ident: pntd.0011441.ref012
  article-title: The Global Trachoma Mapping Project: Methodology of a 34-Country Population-Based Study
  publication-title: Ophthalmic Epidemiol
  doi: 10.3109/09286586.2015.1037401
  contributor:
    fullname: AW Solomon
– volume: 9
  start-page: 5444
  issue: 1
  year: 2018
  ident: pntd.0011441.ref022
  article-title: The utility of serology for elimination surveillance of trachoma
  publication-title: Nat Commun
  doi: 10.1038/s41467-018-07852-0
  contributor:
    fullname: A Pinsent
– volume: 23
  start-page: 575
  issue: 12
  year: 2007
  ident: pntd.0011441.ref020
  article-title: Serology
  publication-title: a robust indicator of malaria transmission intensity? Trends Parasitol
  contributor:
    fullname: P Corran
– volume: 98
  start-page: 216
  issue: 1
  year: 2018
  ident: pntd.0011441.ref024
  article-title: Prevalence of Chlamydia trachomatis-Specific Antibodies before and after Mass Drug Administration for Trachoma in Community-Wide Surveys of Four Communities in Nepal
  publication-title: Am J Trop Med Hyg
  doi: 10.4269/ajtmh.17-0102
  contributor:
    fullname: SE Gwyn
– volume: 95
  start-page: 349
  issue: 30
  year: 2020
  ident: pntd.0011441.ref003
  article-title: WHO Alliance for the Global Elimination of Trachoma by 2020
  publication-title: progress report, 2019. Weekly Epidemiological Record
  contributor:
    fullname: World Health Organization
– volume: 3
  start-page: e462
  issue: 6
  year: 2009
  ident: pntd.0011441.ref010
  article-title: The development of an age-structured model for trachoma transmission dynamics, pathogenesis and control
  publication-title: PLoS Negl Trop Dis
  doi: 10.1371/journal.pntd.0000462
  contributor:
    fullname: M Gambhir
– volume: 11
  start-page: e0005863
  issue: 9
  year: 2017
  ident: pntd.0011441.ref008
  article-title: Prevalence of signs of trachoma, ocular Chlamydia trachomatis infection and antibodies to Pgp3 in residents of Kiritimati Island, Kiribati
  publication-title: PLoS Negl Trop Dis
  doi: 10.1371/journal.pntd.0005863
  contributor:
    fullname: A Cama
SSID ssj0059581
Score 2.4335058
Snippet Baseline mapping in the two major population centers of Kiribati showed that trachoma was a public health problem in need of programmatic interventions. After...
SourceID plos
doaj
pubmedcentral
osti
proquest
gale
crossref
pubmed
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
StartPage e0011441
SubjectTerms Antibodies
Antigens
Azithromycin
Biology and Life Sciences
Disease control
Dosage and administration
Drinking water
Drug therapy
Drugs
Earth Sciences
Ethics
Evaluation
Eye examinations
Health aspects
Households
Indicators
Infections
Infectious Diseases
Medical laboratories
Medicine and Health Sciences
Nucleotide sequence
Parasitology
Patient outcomes
People and Places
Polls & surveys
Polyvinyl alcohol
Prevalence studies (Epidemiology)
Public health
Research and Analysis Methods
Seroconversion
Serology
Surveys
Tetracycline
Tetracyclines
Towns
Trachoma
Tropical diseases
Tropical Medicine
Viral antibodies
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELbQHhAXxLtpCxgJiQuhie04zrEgqgpUTlTqzfIrsBKbrHazIPgV_GRm7GzUoEpcuMYT79rzjfON7Zkh5KVwPgCLb3MvK5ML38rcgCuUi6YQLZdNmTb0Lz7J80vx4aq6ulbqC--EpfTAaeJOeGgCFlMRRgjhuVBWsgCOsqqdbcqQqFHB9s5UWoOrporlSYGdYMQVq8egOV6XJ6OO3qy7wcdzCCHK2Ucp5u6fVuhFD6aGmU-_9dubWOjflymvfZ3O7pG7I62kp2k498mt0D0gty_Gg_OH5HeKItjSZUfhfayQYigeVzt0uuPjj8vN0oKeKG7N0uFHTzdYcmlL-5aaX0usp7D6Cb3RFfBt6je7L9TMMu--pqu04eixuwRtup4KhOX4wfQUBL4Deh6Ry7P3n9-d52MxhtzJig25aME-Aw8FM0FhIStYKFyQrrAqSOPrlpsyOAWI8EACeGulAm6imPC1lcEU_DFZdH0XDggtAQWtKQKvrBJMWNUYG8vlMFE7qdqM5Htt6HXKuaHjwVsNvkqaT43a06P2MvIWVTbJYsbs-ABwpEcc6X_hKCPPUeE6hZ9Odq9P66rhQjY1y8irKIGWj5oyYwADDApzaM0kj2eSYLFu1nyEoNLAcTBRr8MbTW7Q6PzJgmfkALG2H-lWM4XBxQKsB_rd4-_m5hdTM_4kXp_rQr9DGY6J9uAfZORJgus0WzzmLypgFtUMyLPpnLd0y68xEXlZIFvlzeH_UMARucOAQMar0PUxWQybXXgKhG-wz6Jt_wFrj1Nx
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: ProQuest Central
  dbid: BENPR
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3da9UwFA96ByKI6PxY3dQIgi_WtU2apk-yycZQNkQc7K2kSboVvO313l5F_wr_ZM9JcquV4WtzSNucj_xyTs45hLzk2lhA8U1sRK5ibhoRKzgKxbxMeMNEmXqH_umZODnn7y_yi-BwW4VrlRub6Ay16TX6yPcziSmWHOZ4u_gaY9cojK6GFho3yVaWMilnZOvw6Ozjp40tzsvctSkFlIKZV1kRkudYke4HXr1ZdINx8QjO08nm5Gr4j5Z61oPKYQXUL_3qOjT676XKv3ap43vkboCX9MDLw31yw3bb5NZpCKBvkzveTUd99tED8stnF6xo21GYDzunKIphbI2Hcff4Q7tsa-AfRZctHb73dImtmFa0b6j62WKfhfkPmJ3OAYdTs1xfUjWpyPuazr0j0uB0XuTpYmwcFuNGaigQfAOpekjOj48-vzuJQ5OGWIs8G2LegN5aZpNMWYkNrsCAaCt0UksrlCkaplKrJUiKAXDAmlpIwCwy46aohVUJe0RmXd_ZHUJTkI5GJZblteQZr2WpatdGJ-OFFrKJSLzhTrXwtTgqF5Ar4Azj17dCblaBmxE5RBaOtFhJ2z3ol5dVUMyK2dJisx6uOOeGcVmLzJYS7Jiuy9SqiDxHAah8WupoD6qDIi8ZF2WRReSVo0CLgJxSIbEBfgpra00o9yaUoMl6MryLQlYB9sECvhpvOumhwkOhSFhEdlD2Nn-6qv5oBMy7kcfrh1-Mw_hKvFbX2X6NNAwL8MEXROSxF99xtZira5TAKsqJYE-WczrStVeuQHmaIIpl5ZP_f9cuuZ0BZHSXn4s9MhuWa_sUIN5QPwt6_Bs-5FHk
  priority: 102
  providerName: ProQuest
– databaseName: Scholars Portal Journals: Open Access
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwdV3di9QwEA_HCSKI6Plx9U6NIPhij7ZJ0_RB5BSPQ1mfXLi3kCbpuXDbrt2uev4V_snOJN1iZe-1maZN5jfJ5GPmR8grbqwDL76Orch1zG0tYg1LoZiXCa-ZKNOwoT_7Is7n_NNFfrFHtpytQweudy7tkE9q3l2d_Pp-_Q4M_q1nbSjS7Usnq6a3_mSBYyT7rQzmRrzkNePjuUJe5jIdAuhuenMyQfk8_uNovd-C2WEW1Kt2vcsj_f9i5T8z1dl9cm9wMelpwMQDsueaA3J7NhyiH5C7YauOhgikh-RPiDBY00VDoT5kT9EUj7INLsj948-LblGBDilu29L-Z0s7pGNa07am-vcCuRaW11A7XYIvTm23uaR6kpX3DV2GzUiL1QXY09VIHhbjZGopCPwAZD0i87OPXz-cxwNRQ2xEnvUxr8F2HXNJpp1EkisYRIwTJqmkE9oWNdOpMxLQYsFBYHUlJOom47aohNMJe0z2m7Zxh4SmgJBaJ47lleQZr2SpK0-lk_HCCFlHJN5qR61CPg7lD-UKWMeE_lWoTTVoMyLvUYWjLGbT9g_a7lINxqmYKx0S9nDNObeMy0pkrpQwlpmqTJ2OyAsEgAqhqeOYoE6LvGRclEUWkddeAnGKmtJDcAM0CvNrTSSPJ5JgzWZSfIQgU-D_YBJfg7edTK9wYSgSFpFDxN62pWuVSQw85mBZUO8Wj7uLX47F-Em8Wte4doMyDJPwwR9E5EmA79hbzOc2SqAX5QTYk-6cljSLbz5JeZqgJ8vKpzf_8hG5k4HL6C8_F8dkv-827hm4eH313FvtX061Upk
  priority: 102
  providerName: Scholars Portal
Title Changes in trachoma indicators in Kiribati with two rounds of azithromycin mass drug administration, measured in serial population-based surveys
URI https://www.ncbi.nlm.nih.gov/pubmed/37418501
https://www.proquest.com/docview/2851974490
https://search.proquest.com/docview/2835273759
https://www.osti.gov/servlets/purl/2425603
https://pubmed.ncbi.nlm.nih.gov/PMC10355439
https://doaj.org/article/3e9e06734a444d348b62e98787cb91ea
http://dx.doi.org/10.1371/journal.pntd.0011441
Volume 17
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1La9wwEBbJFkIupe-4SbcqFHqps7Yly_IxWRJCy4ZQGtibkWQ5NWTtZdfb0v6K_uTOyA_qklMvPlhj7UozI30jzYOQ99zkFlB84eciVj7PC-ErMIV8nga8YCIN2wP9xbW4uuWflvFyj4g-FsY57Rtdnlb3q9Oq_OZ8K9crM-v9xGY3i3kY4C7J0tk-2Yf9t7fR2_U3TmNXmhSQCUZbRUkXMMeScNbx53RdNbm7gwAwcEgOmEvh0tWF6fcml8J_WKgnNWgcJkC9r7cPgdF_fSr_2qQun5DHHbqkZ-0onpI9Wz0jB4vu_vw5-d0GE2xpWVH4HgulKIq31gZtb_f6c7kpNbCL4gktbX7UdIOVl7a0Lqj6VWJZhdVP6I2uAHbTfLO7o2qUgPcjXbXnjjl210o4XQ91wnzcN3MKBN9BiF6Q28uLr_Mrv6vJ4BsRR43PC1BTy2wQKSuxnhWsF8YKE2hphcqTgqnQGgmCkQMWYIUWEiCKjHieaGFVwF6SSVVX9ojQEIShUIFlsZY84lqmSruqORFPjJCFR_yeG9m6Tb2Rufu3BEyWdj4zZGTWMdIj58iygRYTZ7sX9eYu68QnYza1WJuHK855zrjUIrKphGXL6DS0yiNvkeFZG4U6qH92lsQp4yJNIo98cBS4ACCnVBfHAIPCVFojypMRJSiuGTUfo1BlAHUwX69BxybTZGgDioB55AhlrR_pNoskxhhzUCLot5e_h5vfDc34k-hFV9l6hzQM8-3BP_DIq1Zch9nqdcAjciTIo-kct4B6unzkvTq-_v9Pj8lhBOjR-UEnJ2TSbHb2DaC9Rk9BxZcJPOU8nJJH5xfXN1-m7uQEngsup075_wAVYFnp
link.rule.ids 230,314,727,780,784,864,885,2102,2221,12056,12223,21388,24318,27924,27925,31719,31720,33266,33267,33744,33745,43310,43579,43805,53791,53793,73745,74014,74302
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwELZgkQAJISiPhhZqJCQuhCax4zgnVCqqhT5OrdSb5dhOWYlNlt0sCH4FP5kZxxsIqrjGIyfxfDMej-dByCturAMrvo6tyHXMbS1iDUehmJcJr5ko096hf3omphf802V-GRxuqxBWudGJXlHb1qCPfD-TmGLJYY53i68xdo3C29XQQuMmuQXbfoGolodDiEde5r5JKdgomHeVFSF1jhXpfuDU20XTWX8bwXk62pp8Bf9BT09aEDisf_qlXV1ni_4bUvnXHnX0gNwPxiU96NHwkNxwzRa5fRquz7fIvd5JR_vco0fkV59bsKKzhsJ82DdFU7zENngU94-PZ8tZBdyj6LCl3feWLrER04q2NdU_Z9hlYf4DZqdzsMKpXa6vqB7V431D570b0uJ0PeDpYmgbFuM2aikQfANMPSYXRx_OD6dxaNEQG5FnXcxrkFrHXJJpJ7G9FagP44RJKumEtkXNdOqMBJxYMA1YXQkJFovMuC0q4XTCnpBJ0zZum9AUsFHrxLG8kjzjlSx15ZvoZLwwQtYRiTfcUYu-Eofy13EFnGD69VXITRW4GZH3yMKBFuto-wft8koFsVTMlQ5b9XDNObeMy0pkrpSgxUxVpk5HZA8BoPqk1EEbqIMiLxkXZZFF5LWnQH2AnNIhrQF-CitrjSh3R5Qgx2Y0vIMgU2D5YPleg3FOplN4JBQJi8g2Ym_zpyv1Rx5g3g0erx9-OQzjKzGornHtGmkYlt-DL4jI0x6-w2oxX9UogVWUI2CPlnM80sw--_LkaYI2LCuf_f-79sid6fnpiTr5eHa8Q-5mYDz6MOhil0y65do9B2Ovq154if4NSMFTOg
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwELZgkSokhKA8GlqokZC4EDaJHcc5oVKoCqUVByr1Zjm2U1Zik2U3C4JfwU9mxvEGgiqu8chJPA-PxzPzEfKMG-vAi69jK3Idc1uLWMNRKOZlwmsmyrQP6J-eieNz_v4ivwj5T6uQVrmxid5Q29ZgjHyaSSyx5DDHtA5pER_fHL1afI0RQQpvWgOcxnVyA1HmsI--PBzSPfIy94Cl4K9gDVZWhDI6VqTTwLWXi6az_maC83S0Tflu_oPNnrSgfNgL9Uu7usov_Te98q_96ugOuR0cTXrQS8Zdcs0122TrNFylb5NbfcCO9nVI98ivvs5gRWcNhfkQQ0VTvNA2eCz3j09my1kFnKQYvKXd95YuEZRpRdua6p8zRFyY_4DZ6Rw8cmqX60uqR715X9B5H5K0OF0v_HQxQIjFuKVaCgTfQL7uk_Ojt58Oj-MA1xAbkWddzGvQYMdckmknEeoKTIlxwiSVdELbomY6dUaCzFhwE1hdCQnei8y4LSrhdMIekEnTNm6H0BTkpNaJY3klecYrWerKA-pkvDBC1hGJN9xRi74rh_JXcwWcZvr1VchNFbgZkdfIwoEWe2r7B-3yUgUVVcyVDmF7uOacW8ZlJTJXSrBopipTpyOyjwKg-gLVwTKogyIvGRdlkUXkuadA24Cc0qHEAX4Ku2yNKPdGlKDTZjS8i0KmwAvCVr4Gc55Mp_B4KBIWkR2Uvc2frtQf3YB5N_J49fDTYRhfiQl2jWvXSMOwFR98QUQe9uI7rBbzHY4SWEU5EuzRco5Hmtln36o8TdCfZeWj_3_XPtkCZVYf3p2d7JKbGfiRPiO62COTbrl2j8Hv66onXqF_Axw_V18
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Changes+in+trachoma+indicators+in+Kiribati+with+two+rounds+of+azithromycin+mass+drug+administration%2C+measured+in+serial+population-based+surveys&rft.jtitle=PLoS+neglected+tropical+diseases&rft.au=E.+Brook+Goodhew&rft.au=Taoaba%2C+Raebwebwe&rft.au=Harding-Esch%2C+Emma&rft.au=Gwyn%2C+Sarah&rft.date=2023-07-07&rft.pub=Public+Library+of+Science&rft.eissn=1935-2735&rft.volume=17&rft.issue=7&rft_id=info:doi/10.1371%2Fjournal.pntd.0011441&rft.externalDocID=2851974490
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1935-2735&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1935-2735&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1935-2735&client=summon