No support for premature central nervous system aging in HIV-1 when measured by cerebrospinal fluid phosphorylated tau (p-tau)

• Published in: Virulence Vol. 8; no. 5; pp. 599 - 604
• Main Authors: Krut, Jan J., Price, Richard W., Zetterberg, Henrik, Fuchs, Dietmar, Hagberg, Lars, Yilmaz, Aylin, Cinque, Paola, Nilsson, Staffan, Gisslén, Magnus
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 04.07.2017
• Subjects: Adult; Aging, Premature - diagnosis; Aging, Premature - etiology; Aging, Premature - physiopathology; AIDS Dementia Complex - cerebrospinal fluid; AIDS Dementia Complex - diagnosis; Antiretroviral Therapy, Highly Active; biomarker analysis; Biomarkers - cerebrospinal fluid; Brain - pathology; Brain - virology; cerebrospinal fluid; Cohort Studies; Cross-Sectional Studies; Female; HIV; HIV - isolation & purification; HIV Infections - complications; HIV Infections - drug therapy; HIV Infections - physiopathology; HIV-1 associated cognitive motor complex; Humans; Male; Middle Aged; Neopterin - cerebrospinal fluid; Neurosciences; Neurovetenskaper; Phosphorylation; Research Paper; Retrospective Studies; RNA, Viral - blood; RNA, Viral - cerebrospinal fluid; tau protein; tau Proteins - blood; tau Proteins - cerebrospinal fluid; tau Proteins - chemistry; HIV; HIV-1 associated cognitive motor complex; biomarker analysis; tau protein; cerebrospinal fluid

Background: The prevalence of neurocognitive deficits are reported to be high in HIV-1 positive patients, even with suppressive antiretroviral treatment, and it has been suggested that HIV can cause accelerated aging of the brain. In this study we measured phosphorylated tau (p-tau) in cerebrospinal...