Specific immunotherapy modifies allergen-specific CD4+ T-cell responses in an epitope-dependent manner

• Published in: Journal of allergy and clinical immunology Vol. 133; no. 3; pp. 872 - 879.e7
• Main Authors: Wambre, Erik, DeLong, Jonathan H., James, Eddie A., Torres-Chinn, Nadia, Pfützner, Wolfgang, Möbs, Christian, Durham, Stephen R., Till, Stephen J., Robinson, David, Kwok, William W.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.03.2014; Elsevier; Elsevier Limited
• Subjects: Allergens - immunology; Allergies; allergy; Allergy and Immunology; Biological and medical sciences; CD4; CD4-Positive T-Lymphocytes - immunology; Cytokines; Desensitization, Immunologic; epitope; Epitopes, T-Lymphocyte - immunology; ex vivo; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Grasses; Humans; Immune Tolerance; Immunopathology; Immunophenotyping; Immunotherapy; Lymphocytes; Medical sciences; Peptides; peptide–MHC class II tetramer; peripheral tolerance; Phleum - immunology; pollen; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Statistical analysis; T cell receptors; T cells; Th1 Cells - immunology; Th2 Cells - immunology; Tumor Necrosis Factor Receptor Superfamily, Member 7 - analysis; ASIT; pollen; pMHCII; allergy; peripheral tolerance; T cells; CD4; PE; Immunotherapy; peptide–MHC class II tetramer; ex vivo; epitope; TGP; Allergen-specific immunotherapy; Timothy grass pollen; Peptide–MHC class II; Phycoerythrin; Allergy; Immunopathology; CD4 T lymphocyte; Immune response; Antigenic determinant; Peptides; Major histocompatibility system; Class II histocompatibility antigen; Tolerance; Immunology; Treatment; peptide-MHC class II tetramer; Ex vivo; Tetramer; T-Lymphocyte; Pollen; Allergen

Understanding the mechanisms by which the immune system induces and controls allergic inflammation at the T-cell epitope level is critical for the design of new allergy vaccine strategies. We sought to characterize allergen-specific T-cell responses linked with allergy or peripheral tolerance and to...