A comparison of platelet function tests and thromboxane metabolites to evaluate aspirin response in healthy individuals and patients with coronary artery disease

• Published in: Thrombosis and haemostasis Vol. 103; no. 6; p. 1245
• Main Authors: Grove, Erik Lerkevang, Hvas, Anne-Mette, Johnsen, Helle Ladefoged, Hedegaard, Sofie Sommer, Pedersen, Susanne Bendesgaard, Mortensen, Jette, Kristensen, Steen Dalby
• Format: Journal Article
• Language: English
• Published: Germany 01.06.2010
• Subjects: Arachidonic Acid - metabolism; Aspirin - pharmacology; Blood Platelets - drug effects; Blood Platelets - metabolism; Blood Platelets - pathology; Cells, Cultured; Collagen - metabolism; Coronary Artery Disease - blood; Coronary Artery Disease - diagnosis; Coronary Artery Disease - metabolism; Coronary Artery Disease - urine; Cyclooxygenase 1 - metabolism; Drug Resistance; Enzyme Inhibitors - pharmacology; Epinephrine - pharmacology; Platelet Activation - drug effects; Reproducibility of Results; Sensitivity and Specificity; Thromboxanes - metabolism

Individualised antiplatelet therapy and platelet function testing have attracted considerable clinical interest, but several aspects of test performance have not been thoroughly evaluated. We investigated repeatability and concordance of light transmission aggregometry (LTA) induced with arachidonic...