Involvement of T-complex protein 1-ring complex/chaperonin containing T-complex protein 1 (TRiC/CCT) in retrograde axonal transport through tau phosphorylation

• Published in: Neural regeneration research Vol. 14; no. 4; pp. 588 - 590
• Main Author: Chen, Xu-Qiao
• Format: Journal Article
• Language: English
• Published: India Wolters Kluwer India Pvt. Ltd 01.04.2019; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; Department of Neurosciences, University of California San Diego, La Jolla, CA, USA; Medknow Publications & Media Pvt Ltd; Wolters Kluwer Medknow Publications
• Subjects: Analysis; Artificial chromosomes; Binding sites; Brain research; Brain-derived neurotrophic factor; Cellular signal transduction; Competition; Cyclin-dependent kinases; Disease; Gene expression; Heat shock proteins; Kinases; Molecular chaperones; Nervous system; Phosphorylation; Velocity
• ISSN: 1673-5374; 1876-7958
• DOI: 10.4103/1673-5374.247460

Either overexpression of a single or all eight subunits (CCT1-8) or treatment of the substrate-binding apical domain of yeast CCT1 (ApiCCT1) prevented mutant Huntingtin aggregation and improved cellular and neuronal functions (Zhao et al., 2016). [...]the average retrograde velocity (the relative velocity calculated from moving time with pause time included) in CCT5-expressing neurons was significantly faster than observed in control neurons. [...]an overload of tau in axons may induce an adverse effect on axonal transport (Wang and Mandelkow, 2016). Furthermore, almost all the transfected CCT5 subunits formed a complex in which tau was absent (Chen et al., 2018b). [...]it is possible that the effect of CCT5 on tau phosphorylation requires an oligomeric complex that is either self-assembled by transfected CCT5 or assembled by CCT5 with other endogenous CCT subunits.