Adipose-derived stem cells enhance myogenic differentiation in the mdx mouse model of muscular dystrophy via paracrine signaling

Adipose-derived stem cells have been shown to promote peripheral nerve regeneration through the paracrine secretion of neurotrophic factors. However, it is unclear whether these cells can promote myogenic differentiation in muscular dystrophy. Adipose-derived stem cells (6 × 10 6 ) were injected int...

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Published inNeural regeneration research Vol. 11; no. 10; pp. 1638 - 1643
Main Authors Cao, Ji-qing, Liang, Ying-yin, Li, Ya-qin, Zhang, Hui-li, Zhu, Yu-ling, Geng, Jia, Yang, Li-qing, Feng, Shan-wei, Yang, Juan, Kong, Jie, Zhang, Cheng
Format Journal Article
LanguageEnglish
Published India Wolters Kluwer India Pvt. Ltd 01.10.2016
Medknow Publications and Media Pvt. Ltd
Medknow Publications & Media Pvt. Ltd
Medknow Publications & Media Pvt Ltd
Wolters Kluwer Medknow Publications
Subjects
Analysis
Care and treatment
Health aspects
Immunoglobulins
Insulin
Insulin-like growth factors
Laboratory animals
Morphology
Muscular dystrophy
Mutation
Myogenesis
nerve regeneration; Duchenne muscular dystrophy; adipose-derived stem cells; myogenic differentiation; paracrine pathway; dystrophin; neural regeneration
Protein binding
Proteins
Radiation therapy
Rodents
Statistical analysis
Stem cell transplantation
Stem cells
China
United States > US
adipose-derived stem cells
myogenic differentiation; paracrine pathway
nerve regeneration
neural regeneration
dystrophin
Duchenne muscular dystrophy
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Abstract Adipose-derived stem cells have been shown to promote peripheral nerve regeneration through the paracrine secretion of neurotrophic factors. However, it is unclear whether these cells can promote myogenic differentiation in muscular dystrophy. Adipose-derived stem cells (6 × 10 6 ) were injected into the gastrocnemius muscle of mdx mice at various sites. Dystrophin expression was found in the muscle fibers. Phosphorylation levels of Akt, mammalian target of rapamycin (mTOR), eIF-4E binding protein 1 and S6 kinase 1 were increased, and the Akt/mTOR pathway was activated. Simultaneously, myogenin levels were increased, whereas cleaved caspase 3 and vimentin levels were decreased. Necrosis and fibrosis were reduced in the muscle fibers. These findings suggest that adipose-derived stem cells promote the regeneration and survival of muscle cells by inhibiting apoptosis and fibrosis, thereby alleviating muscle damage in muscular dystrophy.
AbstractList Adipose-derived stem cells have been shown to promote peripheral nerve regeneration through the paracrine secretion of neurotrophic factors. However, it is unclear whether these cells can promote myogenic differentiation in muscular dystrophy. Adipose-derived stem cells (6 × 10 6 ) were injected into the gastrocnemius muscle of mdx mice at various sites. Dystrophin expression was found in the muscle fibers. Phosphorylation levels of Akt, mammalian target of rapamycin (mTOR), eIF-4E binding protein 1 and S6 kinase 1 were increased, and the Akt/mTOR pathway was activated. Simultaneously, myogenin levels were increased, whereas cleaved caspase 3 and vimentin levels were decreased. Necrosis and fibrosis were reduced in the muscle fibers. These findings suggest that adipose-derived stem cells promote the regeneration and survival of muscle cells by inhibiting apoptosis and fibrosis, thereby alleviating muscle damage in muscular dystrophy.
Adipose-derived stem cells have been shown to promote peripheral nerve regeneration through the paracrine secretion of neurotrophic factors. However, it is unclear whether these cells can promote myogenic differentiation in muscular dystrophy. Adipose-derived stem cells (6 × 10 6 ) were injected into the gastrocnemius muscle of mdx mice at various sites. Dystrophin expression was found in the muscle fibers. Phosphorylation levels of Akt, mammalian target of rapamycin (mTOR), eIF-4E binding protein 1 and S6 kinase 1 were increased, and the Akt/mTOR pathway was activated. Simultaneously, myogenin levels were increased, whereas cleaved caspase 3 and vimentin levels were decreased. Necrosis and fibrosis were reduced in the muscle fibers. These findings suggest that adipose-derived stem cells promote the regeneration and survival of muscle cells by inhibiting apoptosis and fibrosis, thereby alleviating muscle damage in muscular dystrophy.
Adipose-derived stem cells have been shown to promote peripheral nerve regeneration through the paracrine secretion of neurotrophic factors. However, it is unclear whether these cells can promote myogenic differentiation in muscular dystrophy. Adipose-derived stem cells (6 × 10 ) were injected into the gastrocnemius muscle of mdx mice at various sites. Dystrophin expression was found in the muscle fibers. Phosphorylation levels of Akt, mammalian target of rapamycin (mTOR), eIF-4E binding protein 1 and S6 kinase 1 were increased, and the Akt/mTOR pathway was activated. Simultaneously, myogenin levels were increased, whereas cleaved caspase 3 and vimentin levels were decreased. Necrosis and fibrosis were reduced in the muscle fibers. These findings suggest that adipose-derived stem cells promote the regeneration and survival of muscle cells by inhibiting apoptosis and fibrosis, thereby alleviating muscle damage in muscular dystrophy.
Audience Academic
Author Yang, Li-qing
Li, Ya-qin
Cao, Ji-qing
Zhang, Cheng
Zhu, Yu-ling
Yang, Juan
Geng, Jia
Zhang, Hui-li
Feng, Shan-wei
Kong, Jie
Liang, Ying-yin
AuthorAffiliation 2 Guangdong Key Laboratory for the Diagnosis and Treatment of Major Neurological Disease, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China
1 Department of Neurology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China
4 Department of Neurology, Yantai Yuhuangding Hospital, Yantai, Shandong Province, China
3 First Affiliated Hospital, Kunming Medical College, Kunming, Yunnan Province, China
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CitedBy_id crossref_primary_10_1089_hum_2017_213
crossref_primary_10_18632_aging_102802
crossref_primary_10_1002_mus_26614
crossref_primary_10_3390_cells10071803
crossref_primary_10_1016_j_mtadv_2024_100465
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10.1002/jcb.24619
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10.1016/j.transproceed.2010.04.031
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Keywords adipose-derived stem cells
myogenic differentiation; paracrine pathway
nerve regeneration
neural regeneration
dystrophin
Duchenne muscular dystrophy
Language English
License http://creativecommons.org/licenses/by-nc-sa/3.0
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Author contributions: JQC collected the data, designed and performed the experiment and wrote the paper. YYL, YQL, HLZ and YLZ collected and analyzed the data. JG, LQY, SWF, JY and JK performed the experiment and analyzed the data. CZ designed the study, revised the paper. All authors approved the final version of the paper.
These authors contributed equally to this paper.
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Snippet Adipose-derived stem cells have been shown to promote peripheral nerve regeneration through the paracrine secretion of neurotrophic factors. However, it is...
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StartPage 1638
SubjectTerms Analysis
Care and treatment
Health aspects
Immunoglobulins
Insulin
Insulin-like growth factors
Laboratory animals
Morphology
Muscular dystrophy
Mutation
Myogenesis
nerve regeneration; Duchenne muscular dystrophy; adipose-derived stem cells; myogenic differentiation; paracrine pathway; dystrophin; neural regeneration
Protein binding
Proteins
Radiation therapy
Rodents
Statistical analysis
Stem cell transplantation
Stem cells
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Title Adipose-derived stem cells enhance myogenic differentiation in the mdx mouse model of muscular dystrophy via paracrine signaling
URI http://www.nrronline.org/article.asp?issn=1673-5374;year=2016;volume=11;issue=10;spage=1638;epage=1643;aulast=Cao;type=0
https://www.ncbi.nlm.nih.gov/pubmed/27904496
https://www.proquest.com/docview/2382723875/abstract/
https://search.proquest.com/docview/1845250615
https://pubmed.ncbi.nlm.nih.gov/PMC5116844
https://doaj.org/article/389b50d152e84bfa895a42550bca8a41
Volume 11
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