Cancer stem cells and chemoradiation resistance

• Published in: Cancer science Vol. 99; no. 10; pp. 1871 - 1877
• Main Authors: Ishii, Hideshi, Iwatsuki, Masaaki, Ieta, Keisuke, Ohta, Daisuke, Haraguchi, Naotsugu, Mimori, Koshi, Mori, Masaki
• Format: Journal Article
• Language: English
• Published: Melbourne, Australia Blackwell Publishing Asia 01.10.2008; Blackwell
• Subjects: Biological and medical sciences; Cell Physiological Phenomena; Cell Transformation, Neoplastic - pathology; Drug Resistance, Neoplasm; Forecasting; Humans; Medical sciences; Neoplasms - drug therapy; Neoplasms - pathology; Neoplastic Stem Cells - pathology; Review; Signal Transduction; Tumors; Resistance; Chemotherapy; Treatment; Cancerology; Stem cell; Combined treatment; Radiotherapy; Tumor cell

Cancer is a disease of genetic and epigenetic alterations, which are emphasized as the central mechanisms of tumor progression in the multistepwise model. Discovery of rare subpopulations of cancer stem cells (CSCs) has created a new focus in cancer research. The heterogeneity of tumors can be expla...