Head and neck cancer in the betel quid chewing area : recent advances in molecular carcinogenesis

• Published in: Cancer science Vol. 99; no. 8; pp. 1507 - 1514
• Main Authors: Chen, Yin‐Ju, Chang, Joseph Tung‐Chieh, Liao, Chun‐Ta, Wang, Hung‐Ming, Yen, Tzu‐Chen, Chiu, Ching‐Chi, Lu, Ya‐Ching, Li, Hsiao‐Fang, Cheng, Ann‐Joy
• Format: Journal Article
• Language: English
• Published: Melbourne, Australia Blackwell Publishing Asia 01.08.2008; Blackwell
• Subjects: Adult; Alcohol Drinking - adverse effects; Areca - adverse effects; Biological and medical sciences; Carcinoma, Squamous Cell - etiology; Carcinoma, Squamous Cell - genetics; Carcinoma, Squamous Cell - metabolism; Female; Genetic Predisposition to Disease; Head and Neck Neoplasms - etiology; Head and Neck Neoplasms - genetics; Head and Neck Neoplasms - metabolism; Humans; Male; Medical sciences; Middle Aged; Mouth Neoplasms - etiology; Mouth Neoplasms - genetics; Mouth Neoplasms - metabolism; Mutation; Otorhinolaryngology (head neck, general aspects and miscellaneous); Otorhinolaryngology. Stomatology; Papillomavirus Infections - complications; Polymorphism, Genetic; Precancerous Conditions - etiology; Precancerous Conditions - genetics; Precancerous Conditions - metabolism; Review; Risk Factors; Smoking - adverse effects; Survival Analysis; Taiwan - epidemiology; Tumors; Taiwan; Carcinogen; Cancerology; ENT disease; Betel; Head and neck cancer; Malignant tumor; Chewing; Carcinogenesis; Cancer
• ISSN: 1347-9032; 1349-7006; 1349-7006
• DOI: 10.1111/j.1349-7006.2008.00863.x

Head and neck cancer (HNC) is one of the 10 most frequent cancers worldwide, with an estimated over 500 000 new cases being diagnosed annually. The overall 5‐year survival rate in patients with HNC is one of the lowest among common malignant neoplasms and has not significantly changed during the las...