Tranexamic acid for the prevention and treatment of bleeding in surgery, trauma and bleeding disorders: a narrative review

• Published in: Thrombosis journal Vol. 19; no. 1; pp. 54 - 16
• Main Authors: Ockerman, Anna, Vanassche, Thomas, Garip, Melisa, Vandenbriele, Christophe, Engelen, Matthias M, Martens, Jeroen, Politis, Constantinus, Jacobs, Reinhilde, Verhamme, Peter
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 11.08.2021; BioMed Central; BMC
• Subjects: Acids; Antifibrinolytic agents; Aprotinin; Blood diseases; Brain; Care and treatment; Clinical trials; Database searching; Disease prevention; Drug dosages; Elective surgery; Epistaxis; Health aspects; Heart surgery; Hemophilia; Hemorrhage; Injuries; Internet/Web search services; Medicin och hälsovetenskap; Menstruation; Mortality; Online searching; Prevention; Review; Rhinoplasty; Tranexamic acid; Transplantation of organs, tissues, etc

We review the evidence for tranexamic acid (TXA) for the treatment and prevention of bleeding caused by surgery, trauma and bleeding disorders. We highlight therapeutic areas where evidence is lacking and discuss safety issues, particularly the concern regarding thrombotic complications. An electron...