Pitx2 regulates gonad morphogenesis

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 105; no. 32; pp. 11242 - 11247
• Main Authors: Rodríguez-León, Joaquín, Esteban, Concepción Rodríguez, Martí, Mercè, Santiago-Josefat, Belén, Dubova, Ilir, Rubiralta, Xavier, Belmonte, Juan Carlos Izpisúa
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 12.08.2008; National Acad Sciences
• Subjects: animal ovaries; Animals; Biological Sciences; Birds; Cell adhesion; Cell Adhesion - physiology; Cell Differentiation - physiology; Cell growth; Cell Proliferation; Cellular biology; Chick Embryo; Chickens; Chickens - physiology; chicks; cortex; Cyclin D1 - metabolism; Embryogenesis; Embryology; Embryonic growth stage; Embryos; epithelium; Epithelium - embryology; Female; females; Gene expression; Gene Expression Regulation, Developmental - physiology; genes; Genetics; Germ cells; Germ Cells - cytology; Germ Cells - physiology; Gonads; Homeobox Protein PITX2; Homeodomain Proteins; Male; males; Mitosis; mitotic spindle apparatus; Morphogenesis; Organ Size; ovarian development; Ovary - cytology; Ovary - embryology; Reproductive system; Spindle Apparatus - metabolism; testes; Testis - cytology; Testis - embryology; Topology; Transcription Factors; Vertebrates

Organ shape and size, and, ultimately, organ function, relate in part to the cell and tissue spatial arrangement that takes place during embryonic development. Despite great advances in the genetic regulatory networks responsible for tissue and organ development, it is not yet clearly understood how...