Role of leptin receptor gene polymorphisms in susceptibility to the development of essential hypertension: a case–control association study in a Northern Han Chinese population

• Published in: Journal of human hypertension Vol. 28; no. 9; pp. 551 - 556
• Main Authors: Liu, Y, Lou, Y-Q, Liu, K, Liu, J-L, Wang, Z-G, Wen, J, Zhao, Q, Wen, S-J, Xiao, L
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.09.2014; Nature Publishing Group
• Subjects: 631/208/457/649; 692/699/75/243; Adult; Asians - genetics; Blood Pressure - genetics; Case-Control Studies; Chi-Square Distribution; China - epidemiology; Development and progression; Disease susceptibility; Epidemiology; Female; Genetic aspects; Genetic Association Studies; Genetic polymorphisms; Genetic Predisposition to Disease; Genotype; Haplotypes; Health Administration; Humans; Hypertension; Hypertension - ethnology; Hypertension - genetics; Hypertension - physiopathology; Leptin; Linkage Disequilibrium; Logistic Models; Male; Medicine; Medicine & Public Health; Middle Aged; Odds Ratio; Original; original-article; Phenotype; Physiological aspects; Polymorphism, Genetic; Public Health; Receptors, Leptin - genetics; Risk Assessment; Risk Factors; China; essential hypertension; Chinese; haplotypes; polymorphism; leptin receptor; linkage disequilibrium
• ISSN: 0950-9240; 1476-5527; 1476-5527
• DOI: 10.1038/jhh.2013.149

In order to explore the potential association between the leptin receptor (LEPR) gene polymorphisms and essential hypertension (EH) risk in the Northern Han Chinese population, we recruited 823 hypertensive subjects and 491 healthy control subjects from the Northern Han Chinese. Genotyping was performed to identify the Lys109Arg, Gln223Arg and Lys656Asn polymorphisms of the LEPR gene. Significant associations were found in a dominant genetic model ([GG+AG] vs AA), P =0.007, odds ratio (OR)=3.697, 95% confidence interval (CI) 1.442–9.482), and in homozygote comparison (GG vs AA, P =0.005, OR=3.890, 95% CI 1.501–10.077) for the Gln223Arg polymorphism. No significant association could be found between Lys109Arg or Lys656Asn polymorphism and EH risk. Linkage disequilibrium was detected between the Lys109Arg and Gln223Arg polymorphisms, and haplotype analyses identified that the G-A haplotype was a protective haplotype for EH. Our studies demonstrated that the LEPR Gln223Arg polymorphism had an important role in a patient’s susceptibility to EH in the Northern Han Chinese population.