CREB/TRH pathway in the central nervous system regulates energy expenditure in response to deprivation of an essential amino acid

• Published in: International Journal of Obesity Vol. 39; no. 1; pp. 105 - 113
• Main Authors: Xia, T, Zhang, Q, Xiao, Y, Wang, C, Yu, J, Liu, H, Liu, B, Zhang, Y, Chen, S, Liu, Y, Chen, Y, Guo, F
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.01.2015; Nature Publishing Group
• Subjects: 631/378/1488; 631/443/319/333/1465; 692/699/1702/295; Adenovirus; Adenoviruses; Adipose tissue; Adipose tissue (brown); Amino acids; Animals; Antibodies; Antibodies - pharmacology; Bioenergetics; Biosynthesis; Blotting, Western; Body weight; Cellular signal transduction; Central nervous system; Central Nervous System - metabolism; Central Nervous System - physiopathology; Control; Cyclic AMP response element-binding protein; Deprivation; Diet; Energy; Energy balance; Energy expenditure; Energy metabolism; Energy Metabolism - drug effects; Epidemiology; Experiments; Extracellular signal-regulated kinase; Food intake; Gene expression; Health aspects; Health Promotion and Disease Prevention; Homeostasis; Hormones; Human subjects; Hypothalamus; Hypothalamus - metabolism; Hypothalamus - physiopathology; Injection; Injections, Intraventricular; Internal Medicine; Kinases; Laboratory animals; Leucine; Leucine - deficiency; Male; Medical research; Medicine; Medicine & Public Health; Medicine, Experimental; Metabolic Diseases; Metabolism; Mice; Mice, Inbred C57BL; Nervous system; Nutrient deficiency; Nutrition research; original-article; Oxygen consumption; Phosphatase; Phosphoprotein phosphatase; Physical activity; Physiological aspects; Properties; Protein phosphatase; Proteins; Public Health; Receptors, Thyrotropin-Releasing Hormone - drug effects; Receptors, Thyrotropin-Releasing Hormone - metabolism; Ribonucleic acid; RNA; Signal Transduction; Thyroid gland; Thyroid hormones; Thyroid-stimulating hormone; Thyrotropin releasing factor; Thyrotropin-releasing hormone; Thyrotropin-Releasing Hormone - metabolism; Transcription factors; Triiodothyronine; China; ERK1/2; CREB; TRH; PPP1R3C; hypothalamus; leucine deprivation

Background: In the central nervous system (CNS), thyrotropin-releasing hormone (TRH) has an important role in regulating energy balance. We previously showed that dietary deprivation of leucine in mice increases energy expenditure through CNS-dependent regulation. However, the involvement of central...