Evolution of chromosome organization driven by selection for reduced gene expression noise

• Published in: Nature genetics Vol. 39; no. 8; pp. 945 - 949
• Main Authors: Hurst, Laurence D, Batada, Nizar N
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.08.2007; Nature Publishing Group
• Subjects: Agriculture; analysis; Animal Genetics and Genomics; Animals; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Cancer Research; Chromatin; Chromosomes; Eukaryotic Cells - metabolism; Evolution, Molecular; Fluctuations; Fundamental and applied biological sciences. Psychology; Gene Expression; Gene Function; Gene Order; Genetics; Genetics of eukaryotes. Biological and molecular evolution; Genome; Human Genetics; Hypothesis testing; Models, Genetic; Multigene Family; Noise reduction; Physiological aspects; Proteins; Yeasts - genetics; United Kingdom; Molecular evolution; Chromosome; Gene expression; Selection

The distribution of genes on eukaryotic chromosomes is nonrandom, but the reasons behind this are not well understood. The commonly observed clustering of essential genes is a case in point. Here we model and test a new hypothesis. Essential proteins are unusual in that random fluctuations in abunda...