Evolution of chromosome organization driven by selection for reduced gene expression noise

The distribution of genes on eukaryotic chromosomes is nonrandom, but the reasons behind this are not well understood. The commonly observed clustering of essential genes is a case in point. Here we model and test a new hypothesis. Essential proteins are unusual in that random fluctuations in abunda...

Full description

Saved in:
Bibliographic Details
Published inNature genetics Vol. 39; no. 8; pp. 945 - 949
Main Authors Hurst, Laurence D, Batada, Nizar N
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group US 01.08.2007
Nature Publishing Group
Subjects
Online AccessGet full text

Cover

Loading…
Abstract The distribution of genes on eukaryotic chromosomes is nonrandom, but the reasons behind this are not well understood. The commonly observed clustering of essential genes is a case in point. Here we model and test a new hypothesis. Essential proteins are unusual in that random fluctuations in abundance (noise) can be highly deleterious. We hypothesize that persistently open chromatin domains are sinks for essential genes, as they enable reduced noise by avoidance of transcriptional bursting associated with chromatin remodeling. Simulation of the model captures clustering and correctly predicts that (i) essential gene clusters are associated with low nucleosome occupancy (ii) noise-sensitive nonessential genes cluster with essential genes (iii) nonessential genes of similar knockout fitness are physically linked (iv) genes in domains rich in essential genes have low noise (v) essential genes are rare subtelomerically and (vi) essential gene clusters are preferentially conserved. We conclude that different noise characteristics of different genomic domains favors nonrandom gene positioning. This has implications for gene therapy and understanding transgenic phenotypes.
AbstractList The distribution of genes on eukaryotic chromosomes is nonrandom, but the reasons behind this are not well understood. The commonly observed clustering of essential genes is a case in point. Here we model and test a new hypothesis. Essential proteins are unusual in that random fluctuations in abundance (noise) can be highly deleterious. We hypothesize that persistently open chromatin domains are sinks for essential genes, as they enable reduced noise by avoidance of transcriptional bursting associated with chromatin remodeling. Simulation of the model captures clustering and correctly predicts that (i) essential gene clusters are associated with low nucleosome occupancy (ii) noise-sensitive nonessential genes cluster with essential genes (iii) nonessential genes of similar knockout fitness are physically linked (iv) genes in domains rich in essential genes have low noise (v) essential genes are rare subtelomerically and (vi) essential gene clusters are preferentially conserved. We conclude that different noise characteristics of different genomic domains favors nonrandom gene positioning. This has implications for gene therapy and understanding transgenic phenotypes.
Audience Academic
Author Hurst, Laurence D
Batada, Nizar N
Author_xml – givenname: Laurence D
  surname: Hurst
  fullname: Hurst, Laurence D
  organization: Department of Biology and Biochemistry, University of Bath
– givenname: Nizar N
  surname: Batada
  fullname: Batada, Nizar N
  organization: Department of Biology and Biochemistry, University of Bath
BackLink http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18948965$$DView record in Pascal Francis
https://www.ncbi.nlm.nih.gov/pubmed/17660811$$D View this record in MEDLINE/PubMed
BookMark eNqN0t1r1TAUAPAiE_eh_gUiRZniQ2dObpKmj2NsOhgM_HrwpaTpSc1ok7ukHZt_vbm7xctVUelDyjm_nPYkZz_bcd5hlj0FcgRkId-6jpISHmR7wJkooAS5k96JgIKRhdjN9mO8IgQYI_JRtgulEEQC7GVfT298P43Wu9ybXH8LfvDRD5j70Clnv6v7VBvsDbq8ucsj9qjvY8aHPGA7aWzzDh3meLsMGOMq57yN-Dh7aFQf8cm8HmSfz04_nbwvLi7fnZ8cXxRacBiLCjRpW6WYoK0UnBiSItAYbNFIKRQreSPS_zatQg6q4ZRVSspSGKObirHFQfZ6XXcZ_PWEcawHGzX2vXLop1hLwSoOXMokX_1VCgmE8EX5T0iJJFwAJPjiF3jlp-BSuzWlVAha8kVCL9eoUz3W1hk_BqVXFetjkEJSymmV1NEfVHpaHKxOt21sim9teLO1IZkRb8dOTTHW5x8__L-9_LJt5-Z18DEGNPUy2EGFuxpIvRq2ej1sCT6fm5-aAdsNm6crgcMZqKhVb4Jy2saNkxWTleCbG4wp5ToMm1P87ZPP1tKpcQr4s9Sc_gG33PEJ
CODEN NGENEC
CitedBy_id crossref_primary_10_1186_s12864_019_5432_8
crossref_primary_10_1007_s12038_015_9506_8
crossref_primary_10_1146_annurev_genet_120215_035400
crossref_primary_10_1007_s00404_017_4347_3
crossref_primary_10_1371_journal_pone_0006396
crossref_primary_10_1186_1471_2164_12_440
crossref_primary_10_1093_molbev_msq192
crossref_primary_10_1016_j_tig_2012_01_006
crossref_primary_10_1038_nature14244
crossref_primary_10_1111_j_1365_2958_2009_06605_x
crossref_primary_10_1242_jeb_114306
crossref_primary_10_1093_molbev_msx264
crossref_primary_10_1101_gr_076059_108
crossref_primary_10_1093_molbev_msab104
crossref_primary_10_1088_1478_3975_acea4e
crossref_primary_10_1371_journal_pcbi_1011581
crossref_primary_10_1371_journal_pone_0155740
crossref_primary_10_1016_j_tig_2009_03_005
crossref_primary_10_1093_gbe_evw050
crossref_primary_10_1073_pnas_1100059108
crossref_primary_10_15252_msb_20177961
crossref_primary_10_1371_journal_pcbi_1005585
crossref_primary_10_15252_msb_20209503
crossref_primary_10_1093_nar_gkt1364
crossref_primary_10_1093_molbev_msr175
crossref_primary_10_1016_j_molcel_2011_11_029
crossref_primary_10_1371_journal_pgen_1000502
crossref_primary_10_1016_j_ygeno_2009_01_008
crossref_primary_10_15252_msb_20145704
crossref_primary_10_1038_nrg2592
crossref_primary_10_1016_j_csbj_2020_01_001
crossref_primary_10_1016_j_bpj_2011_04_021
crossref_primary_10_1073_pnas_1100210108
crossref_primary_10_3389_fgene_2015_00336
crossref_primary_10_1093_molbev_msu131
crossref_primary_10_1016_j_ceb_2010_04_004
crossref_primary_10_1371_journal_pcbi_1002021
crossref_primary_10_1073_pnas_1219381110
crossref_primary_10_1002_cbin_10992
crossref_primary_10_1038_msb_2009_58
crossref_primary_10_1097_MOP_0000000000000072
crossref_primary_10_3389_fgene_2014_00374
crossref_primary_10_1073_pnas_0806317105
crossref_primary_10_1093_nar_gkae432
crossref_primary_10_1088_0256_307X_27_1_010501
crossref_primary_10_1073_pnas_1304461110
crossref_primary_10_1016_j_arr_2013_11_001
crossref_primary_10_1371_journal_pbio_1000115
crossref_primary_10_7554_eLife_29739
crossref_primary_10_1371_journal_pgen_1002077
crossref_primary_10_1016_j_biochi_2014_10_019
crossref_primary_10_1016_j_ygeno_2020_10_037
crossref_primary_10_1038_msb_2008_11
crossref_primary_10_1038_s41514_021_00072_9
crossref_primary_10_1016_j_cels_2020_10_005
crossref_primary_10_1093_gbe_evr025
crossref_primary_10_3389_fmicb_2018_02158
crossref_primary_10_1016_j_compbiolchem_2014_08_017
crossref_primary_10_1093_nar_gkq844
crossref_primary_10_1038_s41467_017_00052_2
crossref_primary_10_1038_s41467_019_11116_w
crossref_primary_10_1016_j_tig_2021_07_008
crossref_primary_10_1016_j_febslet_2012_03_051
crossref_primary_10_1371_journal_pgen_1001011
crossref_primary_10_1093_gbe_evy045
crossref_primary_10_1038_msb_2009_9
crossref_primary_10_1186_1752_0509_6_4
crossref_primary_10_1016_j_cell_2015_02_017
crossref_primary_10_1093_gbe_evu089
crossref_primary_10_1093_gbe_evv179
crossref_primary_10_3390_genes12010049
crossref_primary_10_1007_s11693_010_9055_2
crossref_primary_10_1016_j_fbr_2020_07_001
crossref_primary_10_1371_journal_pgen_1002190
crossref_primary_10_1002_bies_201900205
crossref_primary_10_1093_gbe_evt158
crossref_primary_10_4018_ijsss_2012070102
crossref_primary_10_1093_nar_gkx198
crossref_primary_10_1016_j_celrep_2012_09_017
crossref_primary_10_3109_1040841X_2015_1122571
crossref_primary_10_1016_j_placenta_2012_03_001
crossref_primary_10_1111_j_1420_9101_2009_01817_x
crossref_primary_10_1093_molbev_msx068
crossref_primary_10_1371_journal_pbio_3000519
crossref_primary_10_1038_nrg3092
crossref_primary_10_1186_gb_2011_12_3_r23
crossref_primary_10_1093_nar_gkz1134
crossref_primary_10_1101_gr_139378_112
crossref_primary_10_1186_1471_2164_10_521
crossref_primary_10_1093_molbev_msaa335
crossref_primary_10_1016_j_cell_2008_09_050
crossref_primary_10_1073_pnas_1200790109
crossref_primary_10_1177_1933719111404611
crossref_primary_10_1016_j_pbiomolbio_2012_04_004
crossref_primary_10_1101_gr_142125_112
crossref_primary_10_1089_cmb_2008_15TT
crossref_primary_10_1101_gr_254342_119
crossref_primary_10_1016_j_copbio_2008_06_011
crossref_primary_10_1093_bioinformatics_btp027
crossref_primary_10_1016_j_crme_2012_10_023
crossref_primary_10_1371_journal_pone_0002835
crossref_primary_10_1186_1741_7007_11_15
crossref_primary_10_1016_j_celrep_2012_09_022
crossref_primary_10_1016_j_ijbiomac_2017_03_165
crossref_primary_10_1186_1471_2164_13_343
crossref_primary_10_1186_1471_2105_13_253
crossref_primary_10_1016_j_cbd_2022_100992
crossref_primary_10_1038_s41467_021_27070_5
crossref_primary_10_1016_j_ceb_2015_10_005
crossref_primary_10_1371_journal_pbio_1000329
crossref_primary_10_1371_journal_pgen_1002443
crossref_primary_10_1146_annurev_biophys_083012_130401
crossref_primary_10_1371_journal_pcbi_1000952
crossref_primary_10_1371_journal_pcbi_1000953
crossref_primary_10_1093_molbev_msw236
crossref_primary_10_1371_journal_pgen_1008389
crossref_primary_10_1016_j_jtbi_2017_07_006
crossref_primary_10_1371_journal_pbio_1000171
crossref_primary_10_1016_j_cels_2016_03_009
crossref_primary_10_1002_biot_202300062
crossref_primary_10_15252_msb_20209539
crossref_primary_10_1074_mcp_RA118_000935
crossref_primary_10_1093_dnares_dsw005
crossref_primary_10_1186_1471_2164_12_91
crossref_primary_10_1371_journal_pgen_1000533
crossref_primary_10_1002_yea_3152
crossref_primary_10_1101_gr_097378_109
crossref_primary_10_1371_journal_pcbi_1003135
crossref_primary_10_1128_JB_00475_09
crossref_primary_10_15252_msb_20177548
crossref_primary_10_1002_pmic_202200220
crossref_primary_10_1186_s13227_022_00206_4
crossref_primary_10_1534_genetics_117_300467
crossref_primary_10_1042_BST0381155
crossref_primary_10_1186_1752_0509_6_128
crossref_primary_10_1073_pnas_0914302107
crossref_primary_10_7554_eLife_37272
crossref_primary_10_1016_j_bbrc_2009_05_072
crossref_primary_10_1098_rsbl_2008_0732
crossref_primary_10_1016_j_tig_2015_04_008
crossref_primary_10_1038_s41467_021_25129_x
crossref_primary_10_4161_nucl_20263
crossref_primary_10_1016_j_gene_2015_03_011
crossref_primary_10_1111_evo_12732
Cites_doi 10.1073/pnas.0403929101
10.1371/journal.pgen.0020032
10.1371/journal.pgen.0030072
10.1073/pnas.240462997
10.1101/gr.1589103
10.1038/ng1616
10.1038/ng1111
10.1371/journal.pbio.0020137
10.1186/1475-4924-1-5
10.1038/ng1400
10.1038/nrg1319
10.1534/genetics.104.036871
10.1016/j.cell.2004.08.011
10.1038/nature00935
10.1093/genetics/57.3.625
10.1126/science.1105891
10.1128/JB.185.19.5673-5684.2003
10.1371/journal.pbio.0040309
10.1101/gad.10.14.1796
10.1186/1471-2164-7-265
10.1073/pnas.95.26.15641
10.1038/nature01278
10.1038/nature04785
10.1002/bies.20435
ContentType Journal Article
Copyright Springer Nature America, Inc. 2007
2007 INIST-CNRS
COPYRIGHT 2007 Nature Publishing Group
Copyright Nature Publishing Group Aug 2007
Copyright_xml – notice: Springer Nature America, Inc. 2007
– notice: 2007 INIST-CNRS
– notice: COPYRIGHT 2007 Nature Publishing Group
– notice: Copyright Nature Publishing Group Aug 2007
DBID IQODW
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
IOV
ISR
3V.
7QL
7QP
7QR
7SS
7T7
7TK
7TM
7U9
7X7
7XB
88A
88E
8AO
8C1
8FD
8FE
8FH
8FI
8FJ
8FK
8G5
ABUWG
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
C1K
CCPQU
DWQXO
FR3
FYUFA
GHDGH
GNUQQ
GUQSH
H94
HCIFZ
K9.
LK8
M0S
M1P
M2O
M7N
M7P
MBDVC
P64
PQEST
PQQKQ
PQUKI
Q9U
RC3
7QO
7X8
DOI 10.1038/ng2071
DatabaseName Pascal-Francis
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
Gale In Context: Opposing Viewpoints
Gale In Context: Science
ProQuest Central (Corporate)
Bacteriology Abstracts (Microbiology B)
Calcium & Calcified Tissue Abstracts
Chemoreception Abstracts
Entomology Abstracts (Full archive)
Industrial and Applied Microbiology Abstracts (Microbiology A)
Neurosciences Abstracts
Nucleic Acids Abstracts
Virology and AIDS Abstracts
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Biology Database (Alumni Edition)
Medical Database (Alumni Edition)
ProQuest Pharma Collection
Public Health Database
Technology Research Database
ProQuest SciTech Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
Research Library (Alumni Edition)
ProQuest Central (Alumni)
ProQuest Central
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Natural Science Collection
Environmental Sciences and Pollution Management
ProQuest One Community College
ProQuest Central Korea
Engineering Research Database
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
Research Library Prep
AIDS and Cancer Research Abstracts
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Biological Sciences
Health & Medical Collection (Alumni Edition)
PML(ProQuest Medical Library)
Research Library
Algology Mycology and Protozoology Abstracts (Microbiology C)
Biological Science Database
Research Library (Corporate)
Biotechnology and BioEngineering Abstracts
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central Basic
Genetics Abstracts
Biotechnology Research Abstracts
MEDLINE - Academic
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
Research Library Prep
ProQuest Central Student
Technology Research Database
ProQuest Central Essentials
Nucleic Acids Abstracts
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
Research Library (Alumni Edition)
ProQuest Natural Science Collection
ProQuest Pharma Collection
Environmental Sciences and Pollution Management
ProQuest Biology Journals (Alumni Edition)
ProQuest Central
Genetics Abstracts
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
Natural Science Collection
ProQuest Central Korea
Bacteriology Abstracts (Microbiology B)
Algology Mycology and Protozoology Abstracts (Microbiology C)
Biological Science Collection
AIDS and Cancer Research Abstracts
ProQuest Research Library
Chemoreception Abstracts
Industrial and Applied Microbiology Abstracts (Microbiology A)
ProQuest Medical Library (Alumni)
ProQuest Public Health
Virology and AIDS Abstracts
ProQuest Biological Science Collection
ProQuest Central Basic
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
Biological Science Database
ProQuest SciTech Collection
Neurosciences Abstracts
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
Entomology Abstracts
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
Engineering Research Database
ProQuest One Academic
Calcium & Calcified Tissue Abstracts
ProQuest Central (Alumni)
Biotechnology Research Abstracts
MEDLINE - Academic
DatabaseTitleList Research Library Prep
MEDLINE
Genetics Abstracts

Genetics Abstracts
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 3
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
Agriculture
EISSN 1546-1718
EndPage 949
ExternalDocumentID 1311402351
A186822529
10_1038_ng2071
17660811
18948965
ng2071
Genre Research Support, Non-U.S. Gov't
Journal Article
GeographicLocations United Kingdom
GeographicLocations_xml – name: United Kingdom
GrantInformation_xml – fundername: Medical Research Council
  grantid: G0300415
GroupedDBID -
08R
123
1AW
29M
39C
3O-
3V.
4.4
53G
55
5BI
5M7
5RE
5S5
70F
7X7
85S
88A
88E
8AO
8C1
8FE
8FH
8FI
8FJ
8G5
8R4
8R5
AADWK
AAEEF
AALRV
AAPBV
AAYJO
AAYOK
AAZLF
ABAWZ
ABDBF
ABEFU
ABFLS
ABGIJ
ABOCM
ABPTK
ABUWG
ACGFS
ACIWK
ACNCT
ACPRK
ADBBV
ADBIT
ADQMX
AEDAW
AENEX
AETEA
AFFNX
AFKRA
AFRAH
AFSHS
AGCDD
AGEZK
AGHTU
AHBCP
AHGBK
AHMBA
AHSBF
ALFFA
ALMA_UNASSIGNED_HOLDINGS
ARMCB
ASPBG
AVWKF
AXYYD
AZFZN
AZQEC
B0M
BBAFP
BBNVY
BENPR
BHPHI
BKKNO
BPHCQ
BVXVI
CS3
DB5
DU5
DWQXO
DZ
EAD
EAP
EBC
EBD
EBS
EE.
EJD
EMB
EMK
EPL
ESX
EXGXG
F5P
FEDTE
FQGFK
FSGXE
FYUFA
G8K
GJ
GNUQQ
GUQSH
GX1
HCIFZ
HVGLF
HZ
IAO
IH2
IHR
INH
INR
IOV
IPNFZ
ISR
ITC
K78
KM
L7B
LK8
M0L
M1P
M2O
M7P
MVM
N9A
NNMJJ
OHM
P2P
PADUT
PQEST
PQQKQ
PQUKI
PRINS
PROAC
PSQYO
Q2X
RIG
RNS
RNT
RNTTT
RVV
SHXYY
SIXXV
SJN
SNYQT
SV3
TAOOD
TBHMF
TDRGL
TN5
TSG
TUS
VQA
X
X7M
XIP
XJT
Y6R
YHZ
ZA5
ZGI
ZXP
ZY4
---
-DZ
-~X
.55
.GJ
0R~
2FS
36B
AAHBH
AARCD
AAYZH
ABCQX
ABDPE
ABJNI
ABLJU
ABTAH
ACBWK
ACGFO
ACMJI
ADFRT
AFBBN
AGAYW
AHOSX
AIBTJ
ALIPV
AMTXH
CCPQU
EMOBN
HMCUK
HZ~
LGEZI
LOTEE
NADUK
NXXTH
ODYON
UKHRP
XOL
~8M
~KM
AADEA
AAEXX
AAJMP
AAUGY
ABEEJ
ABVXF
ACBMV
ACBRV
ACBYP
ACIGE
ACTTH
ACVWB
ADMDM
ADZGE
AEFTE
AGGBP
AJDOV
IQODW
NYICJ
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7QL
7QP
7QR
7SS
7T7
7TK
7TM
7U9
7XB
8FD
8FK
C1K
FR3
H94
K9.
M7N
MBDVC
P64
Q9U
RC3
7QO
7X8
ID FETCH-LOGICAL-c651t-91c0ddaa462d8650f091c1bfedef886a475b6766bdae51ab5249a8876ffcb9443
IEDL.DBID 8C1
ISSN 1061-4036
IngestDate Wed Dec 04 09:54:25 EST 2024
Wed Dec 04 14:26:41 EST 2024
Wed Dec 04 04:49:21 EST 2024
Tue Nov 19 07:19:12 EST 2024
Tue Nov 19 21:41:24 EST 2024
Wed Nov 13 00:04:05 EST 2024
Sat Sep 28 21:42:26 EDT 2024
Sat Sep 28 21:42:05 EDT 2024
Fri Dec 06 02:40:32 EST 2024
Wed Oct 16 00:43:31 EDT 2024
Sun Oct 22 16:03:34 EDT 2023
Thu Dec 12 04:11:23 EST 2024
Tue Jun 15 14:00:59 EDT 2021
IsPeerReviewed true
IsScholarly true
Issue 8
Keywords Molecular evolution
Chromosome
Gene expression
Selection
Language English
License CC BY 4.0
http://www.springer.com/tdm
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c651t-91c0ddaa462d8650f091c1bfedef886a475b6766bdae51ab5249a8876ffcb9443
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
PMID 17660811
PQID 222662753
PQPubID 23462
PageCount 5
ParticipantIDs proquest_miscellaneous_864951588
proquest_miscellaneous_68100537
proquest_miscellaneous_20805611
proquest_journals_222662753
gale_infotracmisc_A186822529
gale_infotracacademiconefile_A186822529
gale_incontextgauss_ISR_A186822529
gale_incontextgauss_IOV_A186822529
crossref_primary_10_1038_ng2071
pubmed_primary_17660811
pascalfrancis_primary_18948965
springer_journals_10_1038_ng2071
nature_primary_ng2071
ProviderPackageCode AEDAW
AAZLF
AADWK
AAYJO
70F
ADQMX
EE.
RNTTT
RVV
ABGIJ
DB5
RNT
AHGBK
PublicationCentury 2000
PublicationDate 2007-08-01
PublicationDateYYYYMMDD 2007-08-01
PublicationDate_xml – month: 08
  year: 2007
  text: 2007-08-01
  day: 01
PublicationDecade 2000
PublicationPlace New York
PublicationPlace_xml – name: New York
– name: London
– name: United States
PublicationTitle Nature genetics
PublicationTitleAbbrev Nat Genet
PublicationTitleAlternate Nat Genet
PublicationYear 2007
Publisher Nature Publishing Group US
Nature Publishing Group
Publisher_xml – sequence: 0
  name: Nature Publishing Group US
– name: Nature Publishing Group
References Seoighe, C. (b15) 2000; 97
Hentges, K.E., Pollock, D.D., Liu, B., Justice, M.J. (10.1371/journal.pgen.0030072 b6) 2007; 3
Nei, M. (b19) 1967; 57
Batada, N.N., Urrutia, A.O., Hurst, L.D. (b18)
Fraser, H.B., Hirsh, A.E., Giaever, G., Kumm, J., Eisen, M.B. (10.1371/journal.pbio.0020137 b9) 2004; 2
Gilbert, N., Boyle, S., Fiegler, H., Woodfine, K., Carter, N.P., Bickmore, W.A. (b21) 2004; 118
Spellman, P.T., Rubin, G.M. (10.1186/1475-4924-1-5 b20) 2002; 1
Krylov, D.M., Wolf, Y.I., Rogozin, I.B., Koonin, E.V. (b23) 2003; 13
Cook, D.L., Gerber, A.N., Tapscott, S.J. (b7) 1998; 95
Pal, C., Hurst, L.D. (b5) 2003; 33
Raj, A., Peskin, C.S., Tranchina, D., Vargas, D.Y., Tyagi, S. (10.1371/journal.pbio.0040309 b12) 2006; 4
Gustafson, A.M., Snitkin, E.S., Parker, S.C.J., DeLisi, C., Kasif, S. (10.1186/1471-2164-7-265 b24) 2006; 7
Giaever, G. (b25) 2002; 418
Lee, C.K., Shibata, Y., Rao, B., Strahl, B.D., Lieb, J.D. (b14) 2004; 36
Amsterdam, A. (b22) 2004; 101
Fischer, G., Rocha, E.P.C., Brunet, F., Vergassola, M., Dujon, B. (10.1371/journal.pgen.0020032 b2) 2006; 2
Knop, M. (b17) 2006; 28
Hurst, L.D., Pal, C., Lercher, M.J. (b1) 2004; 5
Kamath, R.S. (b4) 2003; 421
Newman, J.R. (b8) 2006; 441
Raser, J.M., O'Shea, E.K. (b13) 2005; 309
Gerdes, S.Y. (b3) 2003; 185
Becskei, A., Kaufmann, B.B., van Oudenaarden, A. (b11) 2005; 37
Deutschbauer, A.M. (b10) 2005; 169
Maillet, L. (b16) 1996; 10
RS Kamath (BFng2071_CR4) 2003; 421
KE Hentges (BFng2071_CR6) 2007; 3
CK Lee (BFng2071_CR14) 2004; 36
C Seoighe (BFng2071_CR15) 2000; 97
HB Fraser (BFng2071_CR9) 2004; 2
SY Gerdes (BFng2071_CR3) 2003; 185
A Becskei (BFng2071_CR11) 2005; 37
LD Hurst (BFng2071_CR1) 2004; 5
G Fischer (BFng2071_CR2) 2006; 2
JR Newman (BFng2071_CR8) 2006; 441
AM Gustafson (BFng2071_CR24) 2006; 7
C Pal (BFng2071_CR5) 2003; 33
G Giaever (BFng2071_CR25) 2002; 418
DL Cook (BFng2071_CR7) 1998; 95
L Maillet (BFng2071_CR16) 1996; 10
A Raj (BFng2071_CR12) 2006; 4
A Amsterdam (BFng2071_CR22) 2004; 101
N Gilbert (BFng2071_CR21) 2004; 118
DM Krylov (BFng2071_CR23) 2003; 13
BFng2071_CR18
M Nei (BFng2071_CR19) 1967; 57
AM Deutschbauer (BFng2071_CR10) 2005; 169
JM Raser (BFng2071_CR13) 2005; 309
PT Spellman (BFng2071_CR20) 2002; 1
M Knop (BFng2071_CR17) 2006; 28
References_xml – volume: 28
  start-page: 696
  year: 2006
  end-page: 708
  ident: b17
  publication-title: Bioessays
  contributor:
    fullname: Knop, M.
– volume: 95
  start-page: 15641
  year: 1998
  end-page: 15646
  ident: b7
  publication-title: Proc. Natl. Acad. Sci. USA
  contributor:
    fullname: Tapscott, S.J.
– volume: 10
  start-page: 1796
  year: 1996
  end-page: 1811
  ident: b16
  publication-title: Genes Dev.
  contributor:
    fullname: Maillet, L.
– volume: 2
  start-page: e137
  year: 2004
  ident: 10.1371/journal.pbio.0020137 b9
  publication-title: PLoS Biol. [online]
  contributor:
    fullname: Eisen, M.B.
– volume: 2
  start-page: e32
  year: 2006
  ident: 10.1371/journal.pgen.0020032 b2
  publication-title: PLoS Genet. [online]
  contributor:
    fullname: Dujon, B.
– volume: 101
  start-page: 12792
  year: 2004
  end-page: 12797
  ident: b22
  publication-title: Proc. Natl. Acad. Sci. USA
  contributor:
    fullname: Amsterdam, A.
– volume: 441
  start-page: 840
  year: 2006
  end-page: 846
  ident: b8
  publication-title: Nature
  contributor:
    fullname: Newman, J.R.
– volume: 309
  start-page: 2010
  year: 2005
  end-page: 2013
  ident: b13
  publication-title: Science
  contributor:
    fullname: O'Shea, E.K.
– volume: 185
  start-page: 5673
  year: 2003
  end-page: 5684
  ident: b3
  publication-title: J. Bacteriol.
  contributor:
    fullname: Gerdes, S.Y.
– volume: 33
  start-page: 392
  year: 2003
  end-page: 395
  ident: b5
  publication-title: Nat. Genet.
  contributor:
    fullname: Hurst, L.D.
– volume: 13
  start-page: 2229
  year: 2003
  end-page: 2235
  ident: b23
  publication-title: Genome Res.
  contributor:
    fullname: Koonin, E.V.
– volume: 57
  start-page: 625
  year: 1967
  end-page: 641
  ident: b19
  publication-title: Genetics
  contributor:
    fullname: Nei, M.
– ident: b18
  article-title: Trends Genet
  contributor:
    fullname: Hurst, L.D.
– volume: 37
  start-page: 937
  year: 2005
  end-page: 944
  ident: b11
  publication-title: Nat. Genet.
  contributor:
    fullname: van Oudenaarden, A.
– volume: 97
  start-page: 14433
  year: 2000
  end-page: 14437
  ident: b15
  publication-title: Proc. Natl. Acad. Sci. USA
  contributor:
    fullname: Seoighe, C.
– volume: 7
  start-page: 265
  year: 2006
  ident: 10.1186/1471-2164-7-265 b24
  publication-title: BMC Genomics
  contributor:
    fullname: Kasif, S.
– volume: 3
  start-page: e72
  year: 2007
  ident: 10.1371/journal.pgen.0030072 b6
  publication-title: PLoS Genet. [online]
  contributor:
    fullname: Justice, M.J.
– volume: 36
  start-page: 900
  year: 2004
  end-page: 905
  ident: b14
  publication-title: Nat. Genet.
  contributor:
    fullname: Lieb, J.D.
– volume: 421
  start-page: 231
  year: 2003
  end-page: 237
  ident: b4
  publication-title: Nature
  contributor:
    fullname: Kamath, R.S.
– volume: 418
  start-page: 387
  year: 2002
  end-page: 391
  ident: b25
  publication-title: Nature
  contributor:
    fullname: Giaever, G.
– volume: 169
  start-page: 1915
  year: 2005
  end-page: 1925
  ident: b10
  publication-title: Genetics
  contributor:
    fullname: Deutschbauer, A.M.
– volume: 118
  start-page: 555
  year: 2004
  end-page: 566
  ident: b21
  publication-title: Cell
  contributor:
    fullname: Bickmore, W.A.
– volume: 5
  start-page: 299
  year: 2004
  end-page: 310
  ident: b1
  publication-title: Nat. Rev. Genet.
  contributor:
    fullname: Lercher, M.J.
– volume: 1
  start-page: 5
  year: 2002
  ident: 10.1186/1475-4924-1-5 b20
  publication-title: J. Biol.
  contributor:
    fullname: Rubin, G.M.
– volume: 4
  start-page: e309
  year: 2006
  ident: 10.1371/journal.pbio.0040309 b12
  publication-title: PLoS Biol. [online]
  contributor:
    fullname: Tyagi, S.
– volume: 101
  start-page: 12792
  year: 2004
  ident: BFng2071_CR22
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0403929101
  contributor:
    fullname: A Amsterdam
– ident: BFng2071_CR18
– volume: 2
  start-page: e32
  year: 2006
  ident: BFng2071_CR2
  publication-title: PLoS Genet. [online]
  doi: 10.1371/journal.pgen.0020032
  contributor:
    fullname: G Fischer
– volume: 3
  start-page: e72
  year: 2007
  ident: BFng2071_CR6
  publication-title: PLoS Genet. [online]
  doi: 10.1371/journal.pgen.0030072
  contributor:
    fullname: KE Hentges
– volume: 97
  start-page: 14433
  year: 2000
  ident: BFng2071_CR15
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.240462997
  contributor:
    fullname: C Seoighe
– volume: 13
  start-page: 2229
  year: 2003
  ident: BFng2071_CR23
  publication-title: Genome Res.
  doi: 10.1101/gr.1589103
  contributor:
    fullname: DM Krylov
– volume: 37
  start-page: 937
  year: 2005
  ident: BFng2071_CR11
  publication-title: Nat. Genet.
  doi: 10.1038/ng1616
  contributor:
    fullname: A Becskei
– volume: 33
  start-page: 392
  year: 2003
  ident: BFng2071_CR5
  publication-title: Nat. Genet.
  doi: 10.1038/ng1111
  contributor:
    fullname: C Pal
– volume: 2
  start-page: e137
  year: 2004
  ident: BFng2071_CR9
  publication-title: PLoS Biol. [online]
  doi: 10.1371/journal.pbio.0020137
  contributor:
    fullname: HB Fraser
– volume: 1
  start-page: 5
  year: 2002
  ident: BFng2071_CR20
  publication-title: J. Biol.
  doi: 10.1186/1475-4924-1-5
  contributor:
    fullname: PT Spellman
– volume: 36
  start-page: 900
  year: 2004
  ident: BFng2071_CR14
  publication-title: Nat. Genet.
  doi: 10.1038/ng1400
  contributor:
    fullname: CK Lee
– volume: 5
  start-page: 299
  year: 2004
  ident: BFng2071_CR1
  publication-title: Nat. Rev. Genet.
  doi: 10.1038/nrg1319
  contributor:
    fullname: LD Hurst
– volume: 169
  start-page: 1915
  year: 2005
  ident: BFng2071_CR10
  publication-title: Genetics
  doi: 10.1534/genetics.104.036871
  contributor:
    fullname: AM Deutschbauer
– volume: 118
  start-page: 555
  year: 2004
  ident: BFng2071_CR21
  publication-title: Cell
  doi: 10.1016/j.cell.2004.08.011
  contributor:
    fullname: N Gilbert
– volume: 418
  start-page: 387
  year: 2002
  ident: BFng2071_CR25
  publication-title: Nature
  doi: 10.1038/nature00935
  contributor:
    fullname: G Giaever
– volume: 57
  start-page: 625
  year: 1967
  ident: BFng2071_CR19
  publication-title: Genetics
  doi: 10.1093/genetics/57.3.625
  contributor:
    fullname: M Nei
– volume: 309
  start-page: 2010
  year: 2005
  ident: BFng2071_CR13
  publication-title: Science
  doi: 10.1126/science.1105891
  contributor:
    fullname: JM Raser
– volume: 185
  start-page: 5673
  year: 2003
  ident: BFng2071_CR3
  publication-title: J. Bacteriol.
  doi: 10.1128/JB.185.19.5673-5684.2003
  contributor:
    fullname: SY Gerdes
– volume: 4
  start-page: e309
  year: 2006
  ident: BFng2071_CR12
  publication-title: PLoS Biol. [online]
  doi: 10.1371/journal.pbio.0040309
  contributor:
    fullname: A Raj
– volume: 10
  start-page: 1796
  year: 1996
  ident: BFng2071_CR16
  publication-title: Genes Dev.
  doi: 10.1101/gad.10.14.1796
  contributor:
    fullname: L Maillet
– volume: 7
  start-page: 265
  year: 2006
  ident: BFng2071_CR24
  publication-title: BMC Genomics
  doi: 10.1186/1471-2164-7-265
  contributor:
    fullname: AM Gustafson
– volume: 95
  start-page: 15641
  year: 1998
  ident: BFng2071_CR7
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.95.26.15641
  contributor:
    fullname: DL Cook
– volume: 421
  start-page: 231
  year: 2003
  ident: BFng2071_CR4
  publication-title: Nature
  doi: 10.1038/nature01278
  contributor:
    fullname: RS Kamath
– volume: 441
  start-page: 840
  year: 2006
  ident: BFng2071_CR8
  publication-title: Nature
  doi: 10.1038/nature04785
  contributor:
    fullname: JR Newman
– volume: 28
  start-page: 696
  year: 2006
  ident: BFng2071_CR17
  publication-title: Bioessays
  doi: 10.1002/bies.20435
  contributor:
    fullname: M Knop
SSID ssj0014408
Score 2.3647206
Snippet The distribution of genes on eukaryotic chromosomes is nonrandom, but the reasons behind this are not well understood. The commonly observed clustering of...
SourceID proquest
gale
crossref
pubmed
pascalfrancis
springer
nature
SourceType Aggregation Database
Index Database
Publisher
StartPage 945
SubjectTerms Agriculture
analysis
Animal Genetics and Genomics
Animals
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Cancer Research
Chromatin
Chromosomes
Eukaryotic Cells - metabolism
Evolution, Molecular
Fluctuations
Fundamental and applied biological sciences. Psychology
Gene Expression
Gene Function
Gene Order
Genetics
Genetics of eukaryotes. Biological and molecular evolution
Genome
Human Genetics
Hypothesis testing
Models, Genetic
Multigene Family
Noise reduction
Physiological aspects
Proteins
Yeasts - genetics
Title Evolution of chromosome organization driven by selection for reduced gene expression noise
URI http://dx.doi.org/10.1038/ng2071
https://link.springer.com/article/10.1038/ng2071
https://www.ncbi.nlm.nih.gov/pubmed/17660811
https://www.proquest.com/docview/222662753
https://search.proquest.com/docview/20805611
https://search.proquest.com/docview/68100537
https://search.proquest.com/docview/864951588
Volume 39
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3db9QwDI_YJiQkhPgYo2wcEULiqVpzbdP0CY3ppsHDQIOhEy9VPgcPtMf1DrH_HrtJe1RwvLZW69qO_Uvt2IS8tLZ0TjsXS6Z0nDlYcxIiYawSVapE24SbrtvnBT-_yt7N83mozWlDWWXvEztHbRqN_8iPIY51vcrT14sfMQ6NwuRqmKCxQ_YYxjk8KH46VHhg2tKfhOO4TcIspR8tlIrj-nqaFGwUi4JHHhpq3l3IFsTk_HyLfwHQv5KnXUw6u0_uBTBJT7z2H5Bbtn5IbvvxkjePyJfZz2BYtHFUf8XKu7b5bmnzxwFMapbo8Ki6oW03EwevAZKlS2zqag0FC7PU_goFszWtm2-t3SdXZ7NPp-dxmKUQa56zFfg0nRgjZcanRgAqc4ATNFPOGuuE4DIrcsULzpWRNmdS5bAtk-CAOGhSlVmWPia7dVPbJ4RC3DNJmcpSpgA_FDwO9kyssBLBm8ymEXneS7Va-JYZVZfqTkXl5R6RFyjsCvtP1Fjgci3XbVu9ff-5OsH2_eBjpuU2oo-XI6JXgcg1q6XUMhwqAE6xr9WI8mhECatIj27ve8UPLPesTkZ2sPkiUWai5HlEDnvDqMLyb6vBWEEWw118I1a01bZZAwlAdcCubDsFdorDbjsRoVsoBIftLcuFiMiBN8kNe6BLQHvweNrb6Ia9sTae_vcLDskd_zsbax6PyO5qubbPAIet1ITsFPNi0q25Cdl7M7v4cPkbgwU0DQ
link.rule.ids 314,780,784,12056,12223,21388,27924,27925,31719,31720,33266,33267,33744,33745,43310,43579,43805,73745,74014,74302
linkProvider ProQuest
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3db9QwDI9gCDEJIT4GlI0tQkg8VWuvbZo-oWnadIMxJNjQxEuUz8HD2uN6h9h_j92kPSo4XlurdW3H_qV2bEJeW1s5p52LZap0nDtYcxIiYawSValE24SZrtvnGZte5O8ui8tQm9OGssreJ3aO2jQa_5HvQxzrepVnb2c_YhwahcnVMEHjNrkDUb9Eo-aHQ4UHpi39STiG2yTMUvrRQhnfr68mSZmOYlHwyENDzfsz2YKYnJ9v8S8A-lfytItJxw_JgwAm6YHX_iNyy9aPyV0_XvLmCfl69DMYFm0c1d-w8q5tri1t_jiASc0cHR5VN7TtZuLgNUCydI5NXa2hYGGW2l-hYLamdfO9tVvk4vjo_HAah1kKsWZFugCfphNjpMzZxHBAZQ5wgk6Vs8Y6zpnMy0KxkjFlpC1SqQrYlklwQAw0qao8z56Sjbqp7XNCIe6ZpMpkJTOAHwoeB3umtLQSwZvMJxHZ66UqZr5lhuhS3RkXXu4ReYXCFth_osYClyu5bFtx8vGLOMD2_eBjJtU6os-fRkRvApFrFnOpZThUAJxiX6sR5c6IElaRHt3e8oofWO5Z3R3ZweqLeJXzihUR2e4NQ4Tl34rBWEEWw118I1a01bZZAglAdcCu6XoK7BSH3XYiQtdQcAbb27TgPCLPvEmu2ANdAtqDx9PeRlfsjbXx4r9fsEfuTc8_nIrTk7P322TT_9rG-scdsrGYL-1LwGQLtdutvN9yqzSI
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwELagCIRUoQIthL4shMQp2mSTeJ0TqkpXLaCCgKKKi-Vn4UCy3ewi-u-ZiZ0sESzXZJRM7PHM58z4G0JeWFs6p52LZap0nDtYcxIiYawSVapE24SZlu3znJ1e5G8ui8tAKdSEssrOJ7aO2tQa_5GPII61XOXZyIWqiA-vp69m1zE2kMJEa-imcZvcwSZzSKPPj_tqD0xh-lNxDLdMmLH0bYYyPqquxskkHcSl4J17cs3NmWxgyJzvdfEvMPpXIrWNT9Mt8iAAS3rkLeEhuWWrR-SubzV585h8PfkZjIzWjupvWIXX1D8srf84jEnNHJ0fVTe0afvj4DVAtXSOBK_WULA2S-2vUDxb0ar-3thtcjE9-Xx8Goe-CrFmRboA_6YTY6TM2dhwQGgOMINOlbPGOs6ZzCeFYhPGlJG2SKUqYIsmwRkxmFVV5nm2QzaqurJPCYUYaJIyk6XMAIooeBzsn9KJlQjkZD6OyGE3qmLm6TNEm_bOuPDjHpHnONgCuSgqnNYruWwacfb-izhCKn_wN-NyndCnjwOhl0HI1Yu51DIcMABNkeNqILk3kIQVpQe3t_3E9yp3qh4M7GD1RbzMecmKiOx2hiGCK2hEb7gwFv1dfCNWt1W2XoIIwHbAsel6CWSNQ-adiNA1EpzBVjctOI_IE2-SK_VgLgH5weNpZ6Mr9Yaz8ey_X3BI7sGiE-_Ozt_ukvv-LzeWQu6RjcV8afcBni3UQbvwfgPmKjit
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Evolution+of+chromosome+organization+driven+by+selection+for+reduced+gene+expression+noise&rft.jtitle=Nature+genetics&rft.au=BATADA%2C+Nizar+N&rft.au=HURST%2C+Laurence+D&rft.date=2007-08-01&rft.pub=Nature+Publishing+Group&rft.issn=1061-4036&rft.eissn=1546-1718&rft.volume=39&rft.issue=8&rft.spage=945&rft.epage=949&rft_id=info:doi/10.1038%2Fng2071&rft.externalDBID=n%2Fa&rft.externalDocID=18948965
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1061-4036&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1061-4036&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1061-4036&client=summon