Maternal family history of Alzheimer's disease predisposes to reduced brain glucose metabolism

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 104; no. 48; pp. 19067 - 19072
• Main Authors: Mosconi, Lisa, Brys, Miroslaw, Switalski, Remigiusz, Mistur, Rachel, Glodzik, Lidia, Pirraglia, Elizabeth, Tsui, Wai, De Santi, Susan, de Leon, Mony J
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 27.11.2007; National Acad Sciences
• Series: From the Cover
• Subjects: Aged; Aged, 80 and over; Alzheimer disease; Alzheimer Disease - diagnostic imaging; Alzheimer Disease - epidemiology; Alzheimer Disease - genetics; Alzheimer Disease - metabolism; Alzheimer's disease; Alzheimers disease; apolipoprotein E; Apolipoprotein E4 - genetics; Biological Sciences; brain; Brain Mapping; Cerebral Cortex - diagnostic imaging; Cerebral Cortex - metabolism; Cognition & reasoning; cortex; Dementia; education; Effects; Family history; Female; Fluorine Radioisotopes - pharmacokinetics; Fluorodeoxyglucose F18 - pharmacokinetics; gender; Genes, Mitochondrial; Genetic Heterogeneity; Genetic Predisposition to Disease; Genetics; Genomic Imprinting; genotype; Genotypes; Glucose; Glucose - metabolism; Humans; Magnetic Resonance Imaging; Male; memory; Metabolism; Middle Aged; Mitochondrial DNA; Mothers; Neurology; Parents; Parietal lobe; patients; Positron emission tomography; Predisposing factors; Retrospective Studies; Risk; Risk factors; tomography

Having a parent affected with late-onset Alzheimer's disease (AD) is a risk factor for developing AD among cognitively normal subjects. We examined whether cognitively normal subjects with a parental family history of AD show cerebral metabolic rate of glucose (CMRglc) reductions consistent wit...