Ultrasonic-induced tonic convulsion in rats after subchronic exposure to perfluorooctane sulfonate (PFOS)

• Published in: Journal of toxicological sciences Vol. 36; no. 1; pp. 55 - 62
• Main Authors: Sato, Itaru, Yoshida, Midori, Kawamoto, Kosuke, Tsuda, Shuji, Jin, Yihe, Yaegashi, Kaori, Saito, Norimitsu, Liu, Wei
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Society of Toxicology 01.01.2011; Japan Science and Technology Agency
• Subjects: Administration, Oral; Alkanesulfonic Acids - administration & dosage; Alkanesulfonic Acids - pharmacokinetics; Alkanesulfonic Acids - toxicity; Animals; Body Weight - drug effects; Brain - pathology; Convulsion; Dose-Response Relationship, Drug; Eating - drug effects; Environmental Pollutants - administration & dosage; Environmental Pollutants - pharmacokinetics; Environmental Pollutants - toxicity; Epilepsy, Tonic-Clonic - chemically induced; Epilepsy, Tonic-Clonic - pathology; Fluorocarbons - administration & dosage; Fluorocarbons - pharmacokinetics; Fluorocarbons - toxicity; Male; Neurotoxicity; Organ Size - drug effects; PFOS; Rats; Rats, Wistar; Subchronic; Time Factors; Tissue Distribution; Ultrasonics

Perfluorooctane sulfonate (PFOS) is one of the persistent organic pollutants distributed widely in the global environment. We have found that a single oral administration of PFOS induced tonic convulsion in mice and rats when a brief ultrasonic stimulus was applied to the animals. The aim of this st...