Usefulness of Plasma Galectin-3 Levels in Systolic Heart Failure to Predict Renal Insufficiency and Survival

• Published in: The American journal of cardiology Vol. 108; no. 3; pp. 385 - 390
• Main Authors: Tang, W.H. Wilson, Shrestha, Kevin, Shao, Zhili, Borowski, Allen G., Troughton, Richard W., Thomas, James D., Klein, Allan L.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.08.2011; Elsevier; Elsevier Limited
• Subjects: Adult; Age Factors; Aged; Biological and medical sciences; Cardiology; Cardiology. Vascular system; Cardiovascular; Chronic Disease; Cohort Studies; Echocardiography, Doppler; Female; Follow-Up Studies; Galectin 3 - blood; Glomerular Filtration Rate - physiology; Heart; Heart failure; Heart failure, cardiogenic pulmonary edema, cardiac enlargement; Heart Failure, Systolic - blood; Heart Failure, Systolic - diagnostic imaging; Heart Failure, Systolic - mortality; Hemodynamics - physiology; Humans; Kaplan-Meier Estimate; Kidney diseases; Male; Medical sciences; Middle Aged; Mortality; Nephrology. Urinary tract diseases; Nephropathies. Renovascular diseases. Renal failure; Predictive Value of Tests; Prognosis; Proportional Hazards Models; Prospective Studies; Proteins; Reference Values; Renal failure; Renal Insufficiency - blood; Renal Insufficiency - diagnostic imaging; Renal Insufficiency - mortality; Survival Rate; Ultrasonic imaging; Ventricular Dysfunction, Left - blood; Ventricular Dysfunction, Left - diagnostic imaging; Ventricular Dysfunction, Left - mortality; Kidney disease; Heart failure; Biological fluid; Urinary system disease; Prognosis; Cardiovascular disease; Survival; Blood plasma; Heart disease; Renal failure; Level; Circulatory system; Cardiology; Predictive factor

Galectin-3 plays an important role in fibroblast activation and fibrosis in animal models. Increased galectin-3 levels are associated with poor long-term survival in heart failure (HF). We examined the relation between plasma galectin-3 levels and myocardial indexes of systolic HF. We measured plasm...