Catalytic organometallic anticancer complexes

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 105; no. 33; pp. 11628 - 11633
• Main Authors: Dougan, Sarah J, Habtemariam, Abraha, McHale, Sarah E, Parsons, Simon, Sadler, Peter J
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 19.08.2008; National Acad Sciences
• Subjects: animal ovaries; antineoplastic agents; Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; aqueous solutions; biphenyl; Cancer; Catalysis; catalysts; Cell Line, Tumor; Cell lines; Cell Survival - drug effects; Cells; Chlorides; Cytotoxicity; Electrochemistry; Fluorescence; glutathione; Glutathione - metabolism; Humans; Hydrolysis; Iodides; Ligands; Metals; Molecular Structure; neoplasm cells; neoplasms; Neoplasms - metabolism; Neoplasms - pathology; Organic chemicals; Organometallic Compounds - chemical synthesis; Organometallic Compounds - chemistry; Organometallic Compounds - pharmacology; organomineral complexes; Oxidation; Oxidation-Reduction; p-cymene; Physical Sciences; Proteins; Reactive oxygen species; Reactive Oxygen Species - metabolism; Redox reactions; reducing agents; Ruthenium; Ruthenium Compounds - chemical synthesis; Ruthenium Compounds - chemistry; Ruthenium Compounds - pharmacology; Structure-Activity Relationship; Toxicity

Organometallic complexes offer chemistry that is not accessible to purely organic molecules and, hence, potentially new mechanisms of drug action. We show here that the presence of both an iodido ligand and a σ-donor/π-acceptor phenylazopyridine ligand confers remarkable inertness toward ligand subs...