Systemic inflammation alters the neuroinflammatory response: a prospective clinical trial in traumatic brain injury

• Published in: Journal of neuroinflammation Vol. 18; no. 1; p. 221
• Main Authors: Lassarén, Philipp, Lindblad, Caroline, Frostell, Arvid, Carpenter, Keri L H, Guilfoyle, Mathew R, Hutchinson, Peter J A, Helmy, Adel, Thelin, Eric Peter
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 25.09.2021; BioMed Central; BMC
• Subjects: Blood; Brain; Brain - metabolism; Brain Injuries, Traumatic - drug therapy; C-reactive protein; Catheters; Cerebrospinal fluid; Clinical trials; Cytokines; Cytokines - analysis; Cytokines - metabolism; Development and progression; Extracellular Fluid - metabolism; Female; Granulocyte colony-stimulating factor; Health aspects; Human; Humans; IL1-ra; Immunomodulating Agents - therapeutic use; Inflammation; Injuries; Interleukin 1; Interleukin 1 receptor antagonist; Interleukin 1 Receptor Antagonist Protein - therapeutic use; Laboratories; Macrophage inflammatory protein; Male; Medicin och hälsovetenskap; Microdialysis; Microdialysis - methods; Nervous system; Nervous system diseases; Neuroinflammation; Neuroinflammatory Diseases; Patients; Platelet-derived growth factor; Principal components analysis; RANTES; Statistical analysis; Streptococcus infections; Systemic diseases; Traumatic brain injury; Sweden; United Kingdom > UK; United States > US; Human; Infection; Traumatic brain injury; Cytokines; IL1-ra; Neuroinflammation; Inflammation

Neuroinflammation following traumatic brain injury (TBI) has been shown to be associated with secondary injury development; however, how systemic inflammatory mediators affect this is not fully understood. The aim of this study was to see how systemic inflammation affects markers of neuroinflammatio...