Pharmacological Characterization of the Novel Anxiolytic β-Carboline Abecarnil in Rodents and Primates

• Published in: Japanese journal of pharmacology Vol. 64; no. 3; pp. 179 - 188
• Main Authors: Ozawa, Masaki, Nakada, Yukie, Sugimachi, Keiko, Yabuuchi, Fumie, Akai, Tetsuo, Mizuta, Eiji, Kuno, Sadako, Yamaguchi, Motonori
• Format: Journal Article
• Language: English
• Published: Kyoto The Japanese Pharmacological Society 1994; Japanese Pharmacological Society
• Subjects: Abecarnil; Aggression - drug effects; Animals; Anti-Anxiety Agents - metabolism; Anti-Anxiety Agents - pharmacology; Anxiolytic; Behavior, Animal - drug effects; Benzodiazepines; Benzodiazepines - pharmacology; Binding, Competitive; Biological and medical sciences; Carbolines - metabolism; Carbolines - pharmacology; Cerebellum - drug effects; Cerebellum - metabolism; Cerebellum - ultrastructure; Flumazenil - metabolism; GABA; Hexobarbital - pharmacology; Kidney - drug effects; Kidney - metabolism; Kidney - ultrastructure; Macaca fascicularis; Male; Medical sciences; Mice; Mice, Inbred ICR; Motor Activity - drug effects; Neuropharmacology; Pharmacology. Drug treatments; primates; Psycholeptics: tranquillizer, neuroleptic; Psychology. Psychoanalysis. Psychiatry; Psychopharmacology; Rats; Rats, Wistar; Receptors, GABA-A - classification; Receptors, GABA-A - drug effects; Receptors, GABA-A - metabolism; Reflex - drug effects; Spinal Cord - drug effects; Spinal Cord - metabolism; Spinal Cord - ultrastructure; Tritium; β-Carboline; GABA; β-Carboline; Abecarnil; Anxiolytic; Benzodiazepines; Psychotropic; Rodentia; Anxiety disorder; Oral administration; Vertebrata; Chemotherapy; Mammalia; Carboline derivatives; Treatment; Tranquillizer; Animal; Primates; Anxiety; Comparative study

β-Carboline abecarnil was behaviorally and biochemically characterized as a new anxiolytic agent in rodents and primates in comparison with the benzodiazepine (BZ) anxiolytics. Oral treatment with abecarnil (0.5 – 10 mg/kg) showed a potent anticonflict activity in the water-lick test in rats. The mi...