Neuroinflammation in psychiatric disorders: PET imaging and promising new targets

• Published in: The Lancet. Psychiatry Vol. 7; no. 12; p. 1064
• Main Authors: Meyer, Jeffrey H, Cervenka, Simon, Kim, Min-Jeong, Kreisl, William C, Henter, Ioline D, Innis, Robert B
• Format: Journal Article
• Language: English
• Published: England 01.12.2020
• Subjects: Animals; Biomarkers - metabolism; Brain - diagnostic imaging; Brain - pathology; Humans; Inflammation - diagnostic imaging; Mental Disorders - diagnostic imaging; Positron-Emission Tomography; Receptors, GABA - metabolism

Neuroinflammation is a multifaceted physiological and pathophysiological response of the brain to injury and disease. Given imaging findings of 18 kDa translocator protein (TSPO) and the development of radioligands for other inflammatory targets, PET imaging of neuroinflammation is at a particularly...