Evaluation of liposomal amphotericin B for the treatment of fungal keratitis in a tertiary eye care hospital
Purpose: To evaluate the efficacy of liposomal amphotericin B (L-AMB) for the treatment of fungal keratitis. Methods: Patients with fungal keratitis confirmed by potassium hydroxide (KOH) smear and/or confocal microscopy were administered topical L-AMB and randomized into three groups treated with t...
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Published in | Indian journal of ophthalmology Vol. 71; no. 2; pp. 518 - 523 |
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Wolters Kluwer India Pvt. Ltd
01.02.2023
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Abstract | Purpose: To evaluate the efficacy of liposomal amphotericin B (L-AMB) for the treatment of fungal keratitis. Methods: Patients with fungal keratitis confirmed by potassium hydroxide (KOH) smear and/or confocal microscopy were administered topical L-AMB and randomized into three groups treated with three different formulations. The medication was administered two hourly till clinical improvement was achieved, followed by six hourly till complete resolution. The outcome measures were time to clinical improvement, resolution of epithelial defect, stromal infiltrate, hypopyon, extent and density of corneal opacity, neovascularization, and best corrected visual acuity (BCVA) at 3 months. Results: Mean age of the patients was 46.6 ± 14.8 years, and trauma with vegetative matter was the most common predisposing factor. Aspergillus flavus (36%) was the most common fungus cultured, followed by Fusarium (23%). Mean time to clinical improvement, time to resolution of epithelial defect, mean time to resolution of infiltrate, and time to resolution of hypopyon were 3.45 ± 1.38, 25.35 ± 8.46, 37.97 ± 9.94, and 13.33 ± 4.90 days, respectively, and they were comparable among the three groups. There was a significant difference between treatment failure and success cases in terms of days of presentation (P < 0.01), size of the epithelial defect (P-value 0.04), and infiltrate size at presentation (P-value 0.04). At 3 months follow-up, no statistically significant difference was noted in BCVA and mean scar size among groups. Conclusion: L-AMB in a gel form is an effective antifungal agent that promotes the healing of fungal ulcers with notably least vascularization and better tolerance.
Trial registration number: CTRI/2020/04/024550 |
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AbstractList | Purpose: To evaluate the efficacy of liposomal amphotericin B (L-AMB) for the treatment of fungal keratitis. Methods: Patients with fungal keratitis confirmed by potassium hydroxide (KOH) smear and/or confocal microscopy were administered topical L-AMB and randomized into three groups treated with three different formulations. The medication was administered two hourly till clinical improvement was achieved, followed by six hourly till complete resolution. The outcome measures were time to clinical improvement, resolution of epithelial defect, stromal infiltrate, hypopyon, extent and density of corneal opacity, neovascularization, and best corrected visual acuity (BCVA) at 3 months. Results: Mean age of the patients was 46.6 ± 14.8 years, and trauma with vegetative matter was the most common predisposing factor. Aspergillus flavus (36%) was the most common fungus cultured, followed by Fusarium (23%). Mean time to clinical improvement, time to resolution of epithelial defect, mean time to resolution of infiltrate, and time to resolution of hypopyon were 3.45 ± 1.38, 25.35 ± 8.46, 37.97 ± 9.94, and 13.33 ± 4.90 days, respectively, and they were comparable among the three groups. There was a significant difference between treatment failure and success cases in terms of days of presentation (P < 0.01), size of the epithelial defect (P-value 0.04), and infiltrate size at presentation (P-value 0.04). At 3 months follow-up, no statistically significant difference was noted in BCVA and mean scar size among groups. Conclusion: L-AMB in a gel form is an effective antifungal agent that promotes the healing of fungal ulcers with notably least vascularization and better tolerance.
Trial registration number: CTRI/2020/04/024550 Purpose: To evaluate the efficacy of liposomal amphotericin B (L-AMB) for the treatment of fungal keratitis. Methods: Patients with fungal keratitis confirmed by potassium hydroxide (KOH) smear and/or confocal microscopy were administered topical L-AMB and randomized into three groups treated with three different formulations. The medication was administered two hourly till clinical improvement was achieved, followed by six hourly till complete resolution. The outcome measures were time to clinical improvement, resolution of epithelial defect, stromal infiltrate, hypopyon, extent and density of corneal opacity, neovascularization, and best corrected visual acuity (BCVA) at 3 months. Results: Mean age of the patients was 46.6 ± 14.8 years, and trauma with vegetative matter was the most common predisposing factor. Aspergillus flavus (36%) was the most common fungus cultured, followed by Fusarium (23%). Mean time to clinical improvement, time to resolution of epithelial defect, mean time to resolution of infiltrate, and time to resolution of hypopyon were 3.45 ± 1.38, 25.35 ± 8.46, 37.97 ± 9.94, and 13.33 ± 4.90 days, respectively, and they were comparable among the three groups. There was a significant difference between treatment failure and success cases in terms of days of presentation (P < 0.01), size of the epithelial defect (P-value 0.04), and infiltrate size at presentation (P-value 0.04). At 3 months follow-up, no statistically significant difference was noted in BCVA and mean scar size among groups. Conclusion: L-AMB in a gel form is an effective antifungal agent that promotes the healing of fungal ulcers with notably least vascularization and better tolerance. Trial registration number: CTRI/2020/04/024550 PurposeTo evaluate the efficacy of liposomal amphotericin B (L-AMB) for the treatment of fungal keratitis. MethodsPatients with fungal keratitis confirmed by potassium hydroxide (KOH) smear and/or confocal microscopy were administered topical L-AMB and randomized into three groups treated with three different formulations. The medication was administered two hourly till clinical improvement was achieved, followed by six hourly till complete resolution. The outcome measures were time to clinical improvement, resolution of epithelial defect, stromal infiltrate, hypopyon, extent and density of corneal opacity, neovascularization, and best corrected visual acuity (BCVA) at 3 months. ResultsMean age of the patients was 46.6 ± 14.8 years, and trauma with vegetative matter was the most common predisposing factor. Aspergillus flavus (36%) was the most common fungus cultured, followed by Fusarium (23%). Mean time to clinical improvement, time to resolution of epithelial defect, mean time to resolution of infiltrate, and time to resolution of hypopyon were 3.45 ± 1.38, 25.35 ± 8.46, 37.97 ± 9.94, and 13.33 ± 4.90 days, respectively, and they were comparable among the three groups. There was a significant difference between treatment failure and success cases in terms of days of presentation (P < 0.01), size of the epithelial defect (P-value 0.04), and infiltrate size at presentation (P-value 0.04). At 3 months follow-up, no statistically significant difference was noted in BCVA and mean scar size among groups. ConclusionL-AMB in a gel form is an effective antifungal agent that promotes the healing of fungal ulcers with notably least vascularization and better tolerance. Trial registration numberCTRI/2020/04/024550. To evaluate the efficacy of liposomal amphotericin B (L-AMB) for the treatment of fungal keratitis. Patients with fungal keratitis confirmed by potassium hydroxide (KOH) smear and/or confocal microscopy were administered topical L-AMB and randomized into three groups treated with three different formulations. The medication was administered two hourly till clinical improvement was achieved, followed by six hourly till complete resolution. The outcome measures were time to clinical improvement, resolution of epithelial defect, stromal infiltrate, hypopyon, extent and density of corneal opacity, neovascularization, and best corrected visual acuity (BCVA) at 3 months. Mean age of the patients was 46.6 ± 14.8 years, and trauma with vegetative matter was the most common predisposing factor. Aspergillus flavus (36%) was the most common fungus cultured, followed by Fusarium (23%). Mean time to clinical improvement, time to resolution of epithelial defect, mean time to resolution of infiltrate, and time to resolution of hypopyon were 3.45 ± 1.38, 25.35 ± 8.46, 37.97 ± 9.94, and 13.33 ± 4.90 days, respectively, and they were comparable among the three groups. There was a significant difference between treatment failure and success cases in terms of days of presentation (P < 0.01), size of the epithelial defect (P-value 0.04), and infiltrate size at presentation (P-value 0.04). At 3 months follow-up, no statistically significant difference was noted in BCVA and mean scar size among groups. L-AMB in a gel form is an effective antifungal agent that promotes the healing of fungal ulcers with notably least vascularization and better tolerance. CTRI/2020/04/024550. |
Audience | Professional |
Author | Kumar, Vishal Gupta, Noopur Velpandian, T Vanathi, Murugesan Satpathy, Gita Tandon, Radhika Kumari, Pooja Ahmed, Nishat Lomi, Neiwete |
AuthorAffiliation | Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India |
AuthorAffiliation_xml | – name: Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India |
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Keywords | liposomal amphotericin B fungal keratitis Clinical efficacy |
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Paper presented in World Ophthalmology Congress, Barcelona 2018, Manuscript submitted for publication contributor: fullname: Parmanand – volume: 8 start-page: 35 year: 2019 ident: R16-20240828 article-title: Evaluation of liposomal and conventional amphotericin B in experimental fungal keratitis rabbit model publication-title: Transl Vis Sci Technol doi: 10.1167/tvst.8.3.35 contributor: fullname: Rudramurthy – volume: 7 start-page: 907 year: 2021 ident: R1-20240828 article-title: Recent perspectives in the management of fungal keratitis publication-title: J Fungi (Basel) doi: 10.3390/jof7110907 contributor: fullname: Raj – volume: 119 start-page: 1083 year: 2012 ident: R29-20240828 article-title: Voriconazole for fungal corneal ulcers publication-title: Ophthalmology doi: 10.1016/j.ophtha.2011.11.034 contributor: fullname: Parchand – volume: 26 start-page: 398 year: 2007 ident: R14-20240828 article-title: Efficacy of intracameral amphotericin B injection in the management of refractory keratomycosis and endophthalmitis publication-title: Cornea doi: 10.1097/ICO.0b013e318030767e contributor: fullname: Yilmaz – volume: 2 start-page: 114 year: 2009 ident: R26-20240828 article-title: Epidemiological profile of fungal keratitis in urban population of West Bengal, India publication-title: Oman J Ophthalmol doi: 10.4103/0974-620X.57310 contributor: fullname: Saha – volume: 26 start-page: 814 year: 2007 ident: R28-20240828 article-title: Therapeutic effect of intracameral amphotericin B injection in the treatment of fungal keratitis publication-title: Cornea doi: 10.1097/ICO.0b013e31806c791e contributor: fullname: Yoon – volume: 7 start-page: 537 year: 1975 ident: R19-20240828 article-title: Grading corneal ulcers publication-title: Ann Ophthalmol contributor: fullname: Harrison – volume: 124 start-page: 836 year: 1997 ident: R17-20240828 article-title: Treatment of fungal corneal ulcers with amphotericin B ointment publication-title: Am J Ophthalmol doi: 10.1016/S0002-9394(14)71701-5 contributor: fullname: Hirose – volume: 2019 start-page: 6395840 year: 2019 ident: R21-20240828 article-title: Fungal keratitis:Epidemiology, rapid detection, and antifungal susceptibilities of fusarium and aspergillus isolates from corneal scrapings publication-title: Biomed Res Int doi: 10.1155/2019/6395840 contributor: fullname: Manikandan – volume: 26 start-page: 1226 year: 2012 ident: R27-20240828 article-title: Predictors of outcome in fungal keratitis publication-title: Eye doi: 10.1038/eye.2012.99 contributor: fullname: Prajna |
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Snippet | Purpose: To evaluate the efficacy of liposomal amphotericin B (L-AMB) for the treatment of fungal keratitis. Methods: Patients with fungal keratitis confirmed... To evaluate the efficacy of liposomal amphotericin B (L-AMB) for the treatment of fungal keratitis. Patients with fungal keratitis confirmed by potassium... PurposeTo evaluate the efficacy of liposomal amphotericin B (L-AMB) for the treatment of fungal keratitis. MethodsPatients with fungal keratitis confirmed by... |
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SubjectTerms | Acuity Adult Amphotericin B Amphotericin B - therapeutic use Antifungal Agents - therapeutic use clinical efficacy Confocal microscopy Cornea Corneal Ulcer - microbiology Dosage and administration Drug therapy Eye Infections, Fungal - diagnosis Eye Infections, Fungal - drug therapy Eye Infections, Fungal - microbiology fungal keratitis Hospitals Humans Keratitis liposomal amphotericin b Liposomes Middle Aged Original Patients Potassium hydroxide Statistical analysis Testing Ulcers Vascularization |
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Title | Evaluation of liposomal amphotericin B for the treatment of fungal keratitis in a tertiary eye care hospital |
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