Systemic immunosuppressive therapies for uveitis in developing countries

There are multiple approaches to inhibit inflammatory molecules and pathways in noninfectious uveitis. The cornerstone of local and systemic anti-inflammatory treatment is corticosteroid therapy. Corticosteroids remain the most potent and efficacious drugs for treating intraocular inflammation. Howe...

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Published inIndian journal of ophthalmology Vol. 68; no. 9; pp. 1852 - 1862
Main Authors Agrawal, Hitesh, Doan, Hien, Pham, Brandon, Khosla, Amit, Babu, Manohar, McCluskey, Peter, Nguyen, Quan, Sangwan, Virender, Reddy, Subhakar, Sawhney, Sujata, Tyagi, Mudit
Format Journal Article
LanguageEnglish
Published India Wolters Kluwer India Pvt. Ltd 01.09.2020
Medknow Publications and Media Pvt. Ltd
Medknow Publications & Media Pvt. Ltd
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Wolters Kluwer Medknow Publications
Subjects
Adrenal Cortex Hormones
biologicals
Comparative analysis
Corticosteroid drugs
Corticosteroids
Developing Countries
Diagnosis
Drug therapy
Humans
Immune response
Immunosuppression
Immunosuppressive Agents
Inflammation
LDCs
non infectious uveitis
Review
Side effects
Uveitis
Uveitis - drug therapy
India
non infectious uveitis
immunosuppression
corticosteroids
inflammation
Biologicals
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Abstract There are multiple approaches to inhibit inflammatory molecules and pathways in noninfectious uveitis. The cornerstone of local and systemic anti-inflammatory treatment is corticosteroid therapy. Corticosteroids remain the most potent and efficacious drugs for treating intraocular inflammation. However, their long-term use is limited by their medium- and long-term side effects, which are a major concern. The approach taken to limit corticosteroid side effects is to introduce steroid-sparing agents that suppress the inflammatory pathways and immune response differently than corticosteroids. There are several classes of such drugs that are affordable, effective, and generally well-tolerated. Relatively recently, an increasing range of biologic agents has become available to treat intraocular inflammation. However, the relatively expensive cost of these therapies limits their use in the developing world. This systemic review aimst to discuss the use of corticosteroids and different immunosuppressive regimens in the management of various uveitides.
AbstractList There are multiple approaches to inhibit inflammatory molecules and pathways in noninfectious uveitis. The cornerstone of local and systemic anti-inflammatory treatment is corticosteroid therapy. Corticosteroids remain the most potent and efficacious drugs for treating intraocular inflammation. However, their long-term use is limited by their medium- and long-term side effects, which are a major concern. The approach taken to limit corticosteroid side effects is to introduce steroid-sparing agents that suppress the inflammatory pathways and immune response differently than corticosteroids. There are several classes of such drugs that are affordable, effective, and generally well-tolerated. Relatively recently, an increasing range of biologic agents has become available to treat intraocular inflammation. However, the relatively expensive cost of these therapies limits their use in the developing world. This systemic review aimst to discuss the use of corticosteroids and different immunosuppressive regimens in the management of various uveitides.
Audience Professional
Author Reddy, Subhakar
Agrawal, Hitesh
Babu, Manohar
McCluskey, Peter
Nguyen, Quan
Sawhney, Sujata
Khosla, Amit
Doan, Hien
Pham, Brandon
Sangwan, Virender
Tyagi, Mudit
AuthorAffiliation 5 Dr Shroff Charity Eye Hospital, NewDelhi, India
1 Byers Eye Institute, Palo Alto, CA, USA
4 Save Sight Institute, Sydney NSW, Australia
2 Sir Ganga Ram Hospital, New Delhi, India
L V Prasad Eye Institute, Hyderabad, Telangana, India
3 Aravind Eye Institute, Salem, Tamil Nadu, India
AuthorAffiliation_xml – name: L V Prasad Eye Institute, Hyderabad, Telangana, India
– name: 2 Sir Ganga Ram Hospital, New Delhi, India
– name: 4 Save Sight Institute, Sydney NSW, Australia
– name: 5 Dr Shroff Charity Eye Hospital, NewDelhi, India
– name: 3 Aravind Eye Institute, Salem, Tamil Nadu, India
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/32823402$$D View this record in MEDLINE/PubMed
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Issue 9
Keywords non infectious uveitis
immunosuppression
corticosteroids
inflammation
Biologicals
Language English
License http://creativecommons.org/licenses/by-nc-sa/4.0
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Snippet There are multiple approaches to inhibit inflammatory molecules and pathways in noninfectious uveitis. The cornerstone of local and systemic anti-inflammatory...
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SubjectTerms Adrenal Cortex Hormones
biologicals
Comparative analysis
Corticosteroid drugs
Corticosteroids
Developing Countries
Diagnosis
Drug therapy
Humans
Immune response
Immunosuppression
Immunosuppressive Agents
Inflammation
LDCs
non infectious uveitis
Review
Side effects
Uveitis
Uveitis - drug therapy
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Title Systemic immunosuppressive therapies for uveitis in developing countries
URI http://www.ijo.in/article.asp?issn=0301-4738;year=2020;volume=68;issue=9;spage=1852;epage=1862;aulast=Agrawal;type=0
https://www.ncbi.nlm.nih.gov/pubmed/32823402
https://www.proquest.com/docview/2532588196
https://search.proquest.com/docview/2436393096
https://pubmed.ncbi.nlm.nih.gov/PMC7690522
https://doaj.org/article/76dae9bbb44948e493da8057b0afe058
Volume 68
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