5-Hydroxytryptamine promotes hepatocellular carcinoma proliferation by influencing β-catenin

• Published in: Molecular oncology Vol. 10; no. 2; pp. 195 - 212
• Main Authors: Fatima, Sarwat, Shi, Xiaoke, Lin, Zesi, Chen, Guo-qing, Pan, Xiao-hua, Wu, Justin Che-Yuen, Ho, John W., Lee, Nikki P., Gao, Hengjun, Zhang, Ge, Lu, Aiping, Bian, Zhao Xiang
• Format: Journal Article
• Language: English
• Published: United States Elsevier B.V 01.02.2016; John Wiley & Sons, Inc; John Wiley and Sons Inc
• Subjects: 5-HT; Animals; Axin Protein - metabolism; beta Catenin - chemistry; beta Catenin - metabolism; Biochemical analysis; Carcinogenesis - metabolism; Carcinoma, Hepatocellular - metabolism; Carcinoma, Hepatocellular - pathology; Catenin; Cell cycle; Cell Proliferation; Colorectal cancer; Cyclin D1; Cyclin D1 - metabolism; Cytoplasm; Dkk1 protein; Female; Glutamate-ammonia ligase; Glutamate-Ammonia Ligase - metabolism; Glutamine; Hep G2 Cells; Hepatitis; Hepatocellular carcinoma; Humans; Intercellular Signaling Peptides and Proteins - metabolism; Intracellular signalling; Kinases; Liver - pathology; Liver cancer; Liver Neoplasms - metabolism; Liver Neoplasms - pathology; Male; Medical prognosis; Mice; Mice, Inbred BALB C; Mice, Nude; Middle Aged; Phosphorylation; Piperidines - pharmacology; Polymerase chain reaction; Real-Time Polymerase Chain Reaction; Receptors, Serotonin - metabolism; SB-258719; Serotonin - metabolism; Serotonin Antagonists - pharmacology; Sulfonamides - pharmacology; Therapeutic applications; Tumors; Vasoactive agents; Wnt protein; Wnt Signaling Pathway; Wnt/β-catenin signalling; Hong Kong China; United States > US; SB-258719; HCC; qPCR; HCV; SFM; 5-HT; GS; DKK1; HBV; Wnt/β-catenin signalling

5-Hydroxytryptamine (5-HT), a neurotransmitter and vasoactive factor, has been reported to promote proliferation of serum-deprived hepatocellular carcinoma (HCC) cells but the detailed intracellular mechanism is unknown. As Wnt/β-catenin signalling is highly dysregulated in a majority of HCC, this s...