Chemical activation of a food deprivation signal extends lifespan

• Published in: Aging cell Vol. 15; no. 5; pp. 832 - 841
• Main Authors: Lucanic, Mark, Garrett, Theo, Yu, Ivan, Calahorro, Fernando, Asadi Shahmirzadi, Azar, Miller, Aaron, Gill, Matthew S., Hughes, Robert E., Holden‐Dye, Lindy, Lithgow, Gordon J.
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.10.2016; John Wiley and Sons Inc
• Subjects: Aging; Animals; Caenorhabditis; Caenorhabditis elegans - physiology; Caenorhabditis elegans Proteins - metabolism; Caloric Restriction; Chloride Channels - metabolism; dietary restriction; Drug Discovery; Feeding Behavior - drug effects; Food Deprivation - physiology; Glutamate; Glutamates - metabolism; Health aspects; Longevity - drug effects; Longevity - physiology; Models, Biological; Muscle Contraction - drug effects; Mutation - genetics; Neurophysiology; Original; Pharmacogenetics; Pharynx - drug effects; Pharynx - physiology; Receptors, Muscarinic - genetics; Receptors, Muscarinic - metabolism; Signal Transduction - drug effects; Small Molecule Libraries - analysis; Small Molecule Libraries - chemistry; Small Molecule Libraries - pharmacology; Aging; Caenorhabditis; Pharmacogenetics; Drug Discovery; dietary restriction

Summary Model organisms subject to dietary restriction (DR) generally live longer. Accompanying this lifespan extension are improvements in overall health, based on multiple metrics. This indicates that pharmacological treatments that mimic the effects of DR could improve health in humans. To find n...