Chemical activation of a food deprivation signal extends lifespan - Lucanic, Mark; Garrett, Theo; Yu, Ivan; Calahorro, Fernando; Asadi Shahmirzadi, Azar; Miller, Aaron; Gill, Matthew S.; Hughes, Robert E.; Holden‐Dye, Lindy; Lithgow, Gordon J. (Aging cell, 2016)
Keywords: Aging; Animals; Caenorhabditis; Caenorhabditis elegans - physiology; Caenorhabditis elegans Proteins - metabolism; Caloric Restriction; Chloride Channels - metabolism; dietary restriction; Drug Discovery; Feeding Behavior - drug effects; Food Deprivation - physiology; Glutamate; Glutamates - metabolism; Health aspects; Longevity - drug effects; Longevity - physiology; Models, Biological; Muscle Contraction - drug effects; Mutation - genetics; Neurophysiology; Original; Pharmacogenetics; Pharynx - drug effects; Pharynx - physiology; Receptors, Muscarinic - genetics; Receptors, Muscarinic - metabolism; Signal Transduction - drug effects; Small Molecule Libraries - analysis; Small Molecule Libraries - chemistry; Small Molecule Libraries - pharmacology; Aging; Caenorhabditis; Pharmacogenetics; Drug Discovery; dietary restriction