Predictors of adverse neonatal outcomes in intrahepatic cholestasis of pregnancy
Objective We sought to determine predictors of adverse neonatal outcomes in women with intrahepatic cholestasis of pregnancy (ICP). Study Design This study was a multicenter retrospective cohort study of all women diagnosed with ICP across 5 hospital facilities from January 2009 through December 201...
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Published in | American journal of obstetrics and gynecology Vol. 213; no. 4; pp. 570.e1 - 570.e8 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
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Elsevier Inc
01.10.2015
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Abstract | Objective We sought to determine predictors of adverse neonatal outcomes in women with intrahepatic cholestasis of pregnancy (ICP). Study Design This study was a multicenter retrospective cohort study of all women diagnosed with ICP across 5 hospital facilities from January 2009 through December 2014. Obstetric and neonatal complications were evaluated according to total bile acid (TBA) level. Multivariable logistic regression models were developed to evaluate predictors of composite neonatal outcome (neonatal intensive care unit admission, hypoglycemia, hyperbilirubinemia, respiratory distress syndrome, transient tachypnea of the newborn, mechanical ventilation use, oxygen by nasal cannula, pneumonia, and stillbirth). Predictors including TBA level, hepatic transaminase level, gestational age at diagnosis, underlying liver disease, and use of ursodeoxycholic acid were evaluated. Results Of 233 women with ICP, 152 women had TBA levels 10-39.9 μmol/L, 55 had TBA 40-99.9 μmol/L, and 26 had TBA ≥100 μmol/L. There was no difference in maternal age, ethnicity, or prepregnancy body mass index according to TBA level. Increasing TBA level was associated with higher hepatic transaminase and total bilirubin level ( P < .05). TBA levels ≥100 μmol/L were associated with increased risk of stillbirth ( P < .01). Increasing TBA level was also associated with earlier gestational age at diagnosis ( P < .01) and ursodeoxycholic acid use ( P = .02). After adjusting for confounders, no predictors were associated with composite neonatal morbidity. TBA 40-99.9 μmol/L and TBA ≥100 μmol/L were associated with increased risk of meconium-stained amniotic fluid (adjusted odds ratio, 3.55; 95% confidence interval, 1.45–8.68 and adjusted odds ratio, 4.55; 95% confidence interval, 1.47–14.08, respectively). Conclusion In women with ICP, TBA level ≥100 μmol/L was associated with increased risk of stillbirth. TBA ≥40 μmol/L was associated with increased risk of meconium-stained amniotic fluid. |
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AbstractList | Objective We sought to determine predictors of adverse neonatal outcomes in women with intrahepatic cholestasis of pregnancy (ICP). Study Design This study was a multicenter retrospective cohort study of all women diagnosed with ICP across 5 hospital facilities from January 2009 through December 2014. Obstetric and neonatal complications were evaluated according to total bile acid (TBA) level. Multivariable logistic regression models were developed to evaluate predictors of composite neonatal outcome (neonatal intensive care unit admission, hypoglycemia, hyperbilirubinemia, respiratory distress syndrome, transient tachypnea of the newborn, mechanical ventilation use, oxygen by nasal cannula, pneumonia, and stillbirth). Predictors including TBA level, hepatic transaminase level, gestational age at diagnosis, underlying liver disease, and use of ursodeoxycholic acid were evaluated. Results Of 233 women with ICP, 152 women had TBA levels 10-39.9 μmol/L, 55 had TBA 40-99.9 μmol/L, and 26 had TBA ≥100 μmol/L. There was no difference in maternal age, ethnicity, or prepregnancy body mass index according to TBA level. Increasing TBA level was associated with higher hepatic transaminase and total bilirubin level ( P < .05). TBA levels ≥100 μmol/L were associated with increased risk of stillbirth ( P < .01). Increasing TBA level was also associated with earlier gestational age at diagnosis ( P < .01) and ursodeoxycholic acid use ( P = .02). After adjusting for confounders, no predictors were associated with composite neonatal morbidity. TBA 40-99.9 μmol/L and TBA ≥100 μmol/L were associated with increased risk of meconium-stained amniotic fluid (adjusted odds ratio, 3.55; 95% confidence interval, 1.45–8.68 and adjusted odds ratio, 4.55; 95% confidence interval, 1.47–14.08, respectively). Conclusion In women with ICP, TBA level ≥100 μmol/L was associated with increased risk of stillbirth. TBA ≥40 μmol/L was associated with increased risk of meconium-stained amniotic fluid. We sought to determine predictors of adverse neonatal outcomes in women with intrahepatic cholestasis of pregnancy (ICP). This study was a multicenter retrospective cohort study of all women diagnosed with ICP across 5 hospital facilities from January 2009 through December 2014. Obstetric and neonatal complications were evaluated according to total bile acid (TBA) level. Multivariable logistic regression models were developed to evaluate predictors of composite neonatal outcome (neonatal intensive care unit admission, hypoglycemia, hyperbilirubinemia, respiratory distress syndrome, transient tachypnea of the newborn, mechanical ventilation use, oxygen by nasal cannula, pneumonia, and stillbirth). Predictors including TBA level, hepatic transaminase level, gestational age at diagnosis, underlying liver disease, and use of ursodeoxycholic acid were evaluated. Of 233 women with ICP, 152 women had TBA levels 10-39.9 μmol/L, 55 had TBA 40-99.9 μmol/L, and 26 had TBA ≥100 μmol/L. There was no difference in maternal age, ethnicity, or prepregnancy body mass index according to TBA level. Increasing TBA level was associated with higher hepatic transaminase and total bilirubin level (P < .05). TBA levels ≥100 μmol/L were associated with increased risk of stillbirth (P < .01). Increasing TBA level was also associated with earlier gestational age at diagnosis (P < .01) and ursodeoxycholic acid use (P = .02). After adjusting for confounders, no predictors were associated with composite neonatal morbidity. TBA 40-99.9 μmol/L and TBA ≥100 μmol/L were associated with increased risk of meconium-stained amniotic fluid (adjusted odds ratio, 3.55; 95% confidence interval, 1.45–8.68 and adjusted odds ratio, 4.55; 95% confidence interval, 1.47–14.08, respectively). In women with ICP, TBA level ≥100 μmol/L was associated with increased risk of stillbirth. TBA ≥40 μmol/L was associated with increased risk of meconium-stained amniotic fluid. We sought to determine predictors of adverse neonatal outcomes in women with intrahepatic cholestasis of pregnancy (ICP). This study was a multicenter retrospective cohort study of all women diagnosed with ICP across 5 hospital facilities from January 2009 through December 2014. Obstetric and neonatal complications were evaluated according to total bile acid (TBA) level. Multivariable logistic regression models were developed to evaluate predictors of composite neonatal outcome (neonatal intensive care unit admission, hypoglycemia, hyperbilirubinemia, respiratory distress syndrome, transient tachypnea of the newborn, mechanical ventilation use, oxygen by nasal cannula, pneumonia, and stillbirth). Predictors including TBA level, hepatic transaminase level, gestational age at diagnosis, underlying liver disease, and use of ursodeoxycholic acid were evaluated. Of 233 women with ICP, 152 women had TBA levels 10-39.9 μmol/L, 55 had TBA 40-99.9 μmol/L, and 26 had TBA ≥100 μmol/L. There was no difference in maternal age, ethnicity, or prepregnancy body mass index according to TBA level. Increasing TBA level was associated with higher hepatic transaminase and total bilirubin level (P < .05). TBA levels ≥100 μmol/L were associated with increased risk of stillbirth (P < .01). Increasing TBA level was also associated with earlier gestational age at diagnosis (P < .01) and ursodeoxycholic acid use (P = .02). After adjusting for confounders, no predictors were associated with composite neonatal morbidity. TBA 40-99.9 μmol/L and TBA ≥100 μmol/L were associated with increased risk of meconium-stained amniotic fluid (adjusted odds ratio, 3.55; 95% confidence interval, 1.45-8.68 and adjusted odds ratio, 4.55; 95% confidence interval, 1.47-14.08, respectively). In women with ICP, TBA level ≥100 μmol/L was associated with increased risk of stillbirth. TBA ≥40 μmol/L was associated with increased risk of meconium-stained amniotic fluid. |
Author | Ramsey, Patrick S., MD, MSPH Smith, Samuel, MD Kawakita, Tetsuya, MD Fernandez, Miguel, MD Zeymo, Alexander, MS Iqbal, Sara N., MD Huang, Chun-Chih, PhD Parikh, Laura I., MD |
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BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26071912$$D View this record in MEDLINE/PubMed |
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Cites_doi | 10.1097/AOG.0000000000000346 10.1053/j.gastro.2012.08.004 10.1002/hep.26617 10.1542/peds.64.1.30 10.1542/peds.2005-1801 10.1016/j.ajog.2014.07.026 10.1016/j.ajog.2015.02.012 10.1002/hep.20336 10.1016/j.ijgo.2014.09.013 10.1016/S0002-9378(94)70304-3 10.1111/j.1471-0528.2002.01368.x 10.1111/j.1471-0528.2004.00167.x 10.1055/s-2008-1078756 10.1371/journal.pone.0028343 10.1136/bmj.e3799 |
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Keywords | ursodeoxycholic acid neonatal outcome bile acid intrahepatic cholestasis of pregnancy |
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References | Madazli, Yuksel, Oncul, Tuten, Guralp, Aydin (bib17) 2014; 10 Zecca, De Luca, Marras, Caruso, Bernardini, Romagnoli (bib4) 2006; 117 Geenes, Chappell, Seed, Steer, Knight, Williamson (bib8) 2014; 59 Matthews, Warshaw (bib18) 1979; 64 Greenwood, Lalchandani, MacQuillan, Sheil, Murphy, Impey (bib19) 2003; 102 Kenyon, Piercy, Girling, Williamson, Tribe, Shennan (bib2) 2002; 109 Jin, Pan, Huang, Yu, Zhong, Zhang (bib12) 2015; 128 Yeomans, Gilstrap, Leveno, Burris (bib20) 1989; 73 Glantz, Marschall, Mattsson (bib1) 2004; 40 Rioseco, Ivankovic, Manzur (bib5) 1994; 170 Puljic, Kim, Page (bib11) 2015; 212 Williamson, Hems, Goulis (bib3) 2004; 111 Chappell, Gurung, Seed (bib14) 2012; 344 Bacq, Sentilhes, Reyes (bib15) 2012; 143 Brouwers, Koster, Kemperman (bib13) 2015; 212 Gurung, Middleton, Milan, Hague, Thornton (bib16) 2013; 6 Lo, Shaffer, Allen, Little, Cheng, Caughey (bib6) 2014; 28 Rook, Vargas, Caughey, Bacchetti, Rosenthal, Bull (bib10) 2012; 7 Williamson, Geenes (bib7) 2014; 124 Lee, Kwok, Ingles (bib9) 2008; 25 25468047 - Int J Gynaecol Obstet. 2015 Mar;128(3):236-40 24901263 - Obstet Gynecol. 2014 Jul;124(1):120-33 25687562 - Am J Obstet Gynecol. 2015 May;212(5):667.e1-5 22892336 - Gastroenterology. 2012 Dec;143(6):1492-501 25046809 - Am J Obstet Gynecol. 2015 Jan;212(1):100.e1-7 8141222 - Am J Obstet Gynecol. 1994 Mar;170(3):890-5 12850612 - Obstet Gynecol. 2003 Jul;102(1):89-93 25371372 - J Matern Fetal Neonatal Med. 2015;28(18):2254-8 11950183 - BJOG. 2002 Mar;109(3):282-8 15198757 - BJOG. 2004 Jul;111(7):676-81 15368452 - Hepatology. 2004 Aug;40(2):467-74 23857305 - Hepatology. 2014 Apr;59(4):1482-91 18509787 - Am J Perinatol. 2008 Jun;25(6):341-5 450556 - Pediatrics. 1979 Jul;64(1):30-1 22695903 - BMJ. 2012 Jun 13;344:e3799 16651322 - Pediatrics. 2006 May;117(5):1669-72 23794285 - Cochrane Database Syst Rev. 2013 Jun 24;(6):CD000493 22403605 - PLoS One. 2012;7(3):e28343 2911423 - Obstet Gynecol. 1989 Feb;73(2):175-8 Rook (10.1016/j.ajog.2015.06.021_bib10) 2012; 7 Zecca (10.1016/j.ajog.2015.06.021_bib4) 2006; 117 Jin (10.1016/j.ajog.2015.06.021_bib12) 2015; 128 Puljic (10.1016/j.ajog.2015.06.021_bib11) 2015; 212 Matthews (10.1016/j.ajog.2015.06.021_bib18) 1979; 64 Greenwood (10.1016/j.ajog.2015.06.021_bib19) 2003; 102 Williamson (10.1016/j.ajog.2015.06.021_bib3) 2004; 111 Brouwers (10.1016/j.ajog.2015.06.021_bib13) 2015; 212 Glantz (10.1016/j.ajog.2015.06.021_bib1) 2004; 40 Lee (10.1016/j.ajog.2015.06.021_bib9) 2008; 25 Madazli (10.1016/j.ajog.2015.06.021_bib17) 2014; 10 Bacq (10.1016/j.ajog.2015.06.021_bib15) 2012; 143 Kenyon (10.1016/j.ajog.2015.06.021_bib2) 2002; 109 Geenes (10.1016/j.ajog.2015.06.021_bib8) 2014; 59 Chappell (10.1016/j.ajog.2015.06.021_bib14) 2012; 344 Gurung (10.1016/j.ajog.2015.06.021_bib16) 2013; 6 Yeomans (10.1016/j.ajog.2015.06.021_bib20) 1989; 73 Rioseco (10.1016/j.ajog.2015.06.021_bib5) 1994; 170 Williamson (10.1016/j.ajog.2015.06.021_bib7) 2014; 124 Lo (10.1016/j.ajog.2015.06.021_bib6) 2014; 28 |
References_xml | – volume: 59 start-page: 1482 year: 2014 end-page: 1491 ident: bib8 article-title: Association of severe intrahepatic cholestasis of pregnancy with adverse pregnancy outcomes: a prospective population-based case-control study publication-title: Hepatology contributor: fullname: Williamson – volume: 111 start-page: 676 year: 2004 end-page: 681 ident: bib3 article-title: Clinical outcome in a series of cases of obstetric cholestasis identified via a patient support group publication-title: BJOG contributor: fullname: Goulis – volume: 143 start-page: 1492 year: 2012 end-page: 1501 ident: bib15 article-title: Efficacy of ursodeoxycholic acid in treating intrahepatic cholestasis of pregnancy: a meta-analysis publication-title: Gastroenterology contributor: fullname: Reyes – volume: 117 start-page: 1669 year: 2006 end-page: 1672 ident: bib4 article-title: Intrahepatic cholestasis of pregnancy and neonatal respiratory distress syndrome publication-title: Pediatrics contributor: fullname: Romagnoli – volume: 64 start-page: 30 year: 1979 ident: bib18 article-title: Relevance of the gestational age distribution of meconium passage in utero publication-title: Pediatrics contributor: fullname: Warshaw – volume: 40 year: 2004 ident: bib1 article-title: Intrahepatic cholestasis of pregnancy: relationships between bile acid levels and fetal complication rates publication-title: Hepatology contributor: fullname: Mattsson – volume: 7 start-page: e28343 year: 2012 ident: bib10 article-title: Fetal outcomes in pregnancies complicated by intrahepatic cholestasis of pregnancy in a Northern California cohort publication-title: PLoS One contributor: fullname: Bull – volume: 344 start-page: e3799 year: 2012 ident: bib14 article-title: Ursodeoxycholic acid versus placebo, and early term delivery versus expectant management, in women with intrahepatic cholestasis of pregnancy: semifactorial randomized clinical trial publication-title: BMJ contributor: fullname: Seed – volume: 10 start-page: 1 year: 2014 end-page: 4 ident: bib17 article-title: Pregnancy outcomes and prognostic factors in patients with intrahepatic cholestasis of pregnancy publication-title: J Obstet Gynaecol contributor: fullname: Aydin – volume: 212 start-page: 667.e1 year: 2015 end-page: 667.e5 ident: bib11 article-title: The risk of infant and fetal death by each additional week of expectant management in intrahepatic cholestasis of pregnancy by gestational age publication-title: Am J Obstet Gynecol contributor: fullname: Page – volume: 25 start-page: 341 year: 2008 end-page: 345 ident: bib9 article-title: Pregnancy outcomes during an era of aggressive management for intrahepatic cholestasis of pregnancy publication-title: Am J Perinatol contributor: fullname: Ingles – volume: 170 start-page: 890 year: 1994 end-page: 895 ident: bib5 article-title: Intrahepatic cholestasis of pregnancy: a retrospective case-control study of perinatal outcome publication-title: Am J Obstet Gynecol contributor: fullname: Manzur – volume: 28 start-page: 1 year: 2014 end-page: 5 ident: bib6 article-title: Intrahepatic cholestasis of pregnancy and timing of delivery publication-title: J Matern Fetal Neonatal Med contributor: fullname: Caughey – volume: 73 start-page: 175 year: 1989 end-page: 178 ident: bib20 article-title: Meconium in the amniotic fluid and fetal acid-base status publication-title: Obstet Gynecol contributor: fullname: Burris – volume: 212 start-page: 100.e1 year: 2015 end-page: 100.e7 ident: bib13 article-title: Intrahepatic cholestasis of pregnancy: maternal and fetal outcomes associated with elevated bile acid levels publication-title: Am J Obstet Gynecol contributor: fullname: Kemperman – volume: 102 start-page: 89 year: 2003 end-page: 93 ident: bib19 article-title: Meconium passed in labor: how reassuring is clear amniotic fluid? publication-title: Obstet Gynecol contributor: fullname: Impey – volume: 109 start-page: 282 year: 2002 end-page: 288 ident: bib2 article-title: Obstetric cholestasis, outcome with active management: a series of 70 cases publication-title: BJOG contributor: fullname: Shennan – volume: 128 start-page: 236 year: 2015 end-page: 240 ident: bib12 article-title: Risk factors for adverse fetal outcomes among women with early- versus late-onset intrahepatic cholestasis of pregnancy publication-title: Int J Gynaecol Obstet contributor: fullname: Zhang – volume: 124 start-page: 120 year: 2014 end-page: 133 ident: bib7 article-title: Intrahepatic cholestasis of pregnancy publication-title: Obstet Gynecol contributor: fullname: Geenes – volume: 6 start-page: CD000493 year: 2013 ident: bib16 article-title: Interventions for treating cholestasis in pregnancy publication-title: Cochrane Database Syst Rev contributor: fullname: Thornton – volume: 124 start-page: 120 year: 2014 ident: 10.1016/j.ajog.2015.06.021_bib7 article-title: Intrahepatic cholestasis of pregnancy publication-title: Obstet Gynecol doi: 10.1097/AOG.0000000000000346 contributor: fullname: Williamson – volume: 143 start-page: 1492 year: 2012 ident: 10.1016/j.ajog.2015.06.021_bib15 article-title: Efficacy of ursodeoxycholic acid in treating intrahepatic cholestasis of pregnancy: a meta-analysis publication-title: Gastroenterology doi: 10.1053/j.gastro.2012.08.004 contributor: fullname: Bacq – volume: 59 start-page: 1482 year: 2014 ident: 10.1016/j.ajog.2015.06.021_bib8 article-title: Association of severe intrahepatic cholestasis of pregnancy with adverse pregnancy outcomes: a prospective population-based case-control study publication-title: Hepatology doi: 10.1002/hep.26617 contributor: fullname: Geenes – volume: 64 start-page: 30 year: 1979 ident: 10.1016/j.ajog.2015.06.021_bib18 article-title: Relevance of the gestational age distribution of meconium passage in utero publication-title: Pediatrics doi: 10.1542/peds.64.1.30 contributor: fullname: Matthews – volume: 117 start-page: 1669 year: 2006 ident: 10.1016/j.ajog.2015.06.021_bib4 article-title: Intrahepatic cholestasis of pregnancy and neonatal respiratory distress syndrome publication-title: Pediatrics doi: 10.1542/peds.2005-1801 contributor: fullname: Zecca – volume: 28 start-page: 1 year: 2014 ident: 10.1016/j.ajog.2015.06.021_bib6 article-title: Intrahepatic cholestasis of pregnancy and timing of delivery publication-title: J Matern Fetal Neonatal Med contributor: fullname: Lo – volume: 212 start-page: 100.e1 year: 2015 ident: 10.1016/j.ajog.2015.06.021_bib13 article-title: Intrahepatic cholestasis of pregnancy: maternal and fetal outcomes associated with elevated bile acid levels publication-title: Am J Obstet Gynecol doi: 10.1016/j.ajog.2014.07.026 contributor: fullname: Brouwers – volume: 212 start-page: 667.e1 year: 2015 ident: 10.1016/j.ajog.2015.06.021_bib11 article-title: The risk of infant and fetal death by each additional week of expectant management in intrahepatic cholestasis of pregnancy by gestational age publication-title: Am J Obstet Gynecol doi: 10.1016/j.ajog.2015.02.012 contributor: fullname: Puljic – volume: 10 start-page: 1 year: 2014 ident: 10.1016/j.ajog.2015.06.021_bib17 article-title: Pregnancy outcomes and prognostic factors in patients with intrahepatic cholestasis of pregnancy publication-title: J Obstet Gynaecol contributor: fullname: Madazli – volume: 40 year: 2004 ident: 10.1016/j.ajog.2015.06.021_bib1 article-title: Intrahepatic cholestasis of pregnancy: relationships between bile acid levels and fetal complication rates publication-title: Hepatology doi: 10.1002/hep.20336 contributor: fullname: Glantz – volume: 128 start-page: 236 year: 2015 ident: 10.1016/j.ajog.2015.06.021_bib12 article-title: Risk factors for adverse fetal outcomes among women with early- versus late-onset intrahepatic cholestasis of pregnancy publication-title: Int J Gynaecol Obstet doi: 10.1016/j.ijgo.2014.09.013 contributor: fullname: Jin – volume: 102 start-page: 89 year: 2003 ident: 10.1016/j.ajog.2015.06.021_bib19 article-title: Meconium passed in labor: how reassuring is clear amniotic fluid? publication-title: Obstet Gynecol contributor: fullname: Greenwood – volume: 170 start-page: 890 year: 1994 ident: 10.1016/j.ajog.2015.06.021_bib5 article-title: Intrahepatic cholestasis of pregnancy: a retrospective case-control study of perinatal outcome publication-title: Am J Obstet Gynecol doi: 10.1016/S0002-9378(94)70304-3 contributor: fullname: Rioseco – volume: 109 start-page: 282 year: 2002 ident: 10.1016/j.ajog.2015.06.021_bib2 article-title: Obstetric cholestasis, outcome with active management: a series of 70 cases publication-title: BJOG doi: 10.1111/j.1471-0528.2002.01368.x contributor: fullname: Kenyon – volume: 73 start-page: 175 year: 1989 ident: 10.1016/j.ajog.2015.06.021_bib20 article-title: Meconium in the amniotic fluid and fetal acid-base status publication-title: Obstet Gynecol contributor: fullname: Yeomans – volume: 6 start-page: CD000493 year: 2013 ident: 10.1016/j.ajog.2015.06.021_bib16 article-title: Interventions for treating cholestasis in pregnancy publication-title: Cochrane Database Syst Rev contributor: fullname: Gurung – volume: 111 start-page: 676 year: 2004 ident: 10.1016/j.ajog.2015.06.021_bib3 article-title: Clinical outcome in a series of cases of obstetric cholestasis identified via a patient support group publication-title: BJOG doi: 10.1111/j.1471-0528.2004.00167.x contributor: fullname: Williamson – volume: 25 start-page: 341 year: 2008 ident: 10.1016/j.ajog.2015.06.021_bib9 article-title: Pregnancy outcomes during an era of aggressive management for intrahepatic cholestasis of pregnancy publication-title: Am J Perinatol doi: 10.1055/s-2008-1078756 contributor: fullname: Lee – volume: 7 start-page: e28343 year: 2012 ident: 10.1016/j.ajog.2015.06.021_bib10 article-title: Fetal outcomes in pregnancies complicated by intrahepatic cholestasis of pregnancy in a Northern California cohort publication-title: PLoS One doi: 10.1371/journal.pone.0028343 contributor: fullname: Rook – volume: 344 start-page: e3799 year: 2012 ident: 10.1016/j.ajog.2015.06.021_bib14 article-title: Ursodeoxycholic acid versus placebo, and early term delivery versus expectant management, in women with intrahepatic cholestasis of pregnancy: semifactorial randomized clinical trial publication-title: BMJ doi: 10.1136/bmj.e3799 contributor: fullname: Chappell |
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Snippet | Objective We sought to determine predictors of adverse neonatal outcomes in women with intrahepatic cholestasis of pregnancy (ICP). Study Design This study was... We sought to determine predictors of adverse neonatal outcomes in women with intrahepatic cholestasis of pregnancy (ICP). This study was a multicenter... |
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SubjectTerms | Adult Alanine Transaminase - blood Aspartate Aminotransferases - blood bile acid Bile Acids and Salts - blood Cholagogues and Choleretics - therapeutic use Cholestasis, Intrahepatic - blood Cholestasis, Intrahepatic - drug therapy Cholestasis, Intrahepatic - epidemiology Cohort Studies Female Gestational Age Humans Hyperbilirubinemia - epidemiology Hypoglycemia - epidemiology Infant, Newborn Intensive Care Units, Neonatal - utilization intrahepatic cholestasis of pregnancy Logistic Models Multivariate Analysis neonatal outcome Obstetrics and Gynecology Oxygen Inhalation Therapy - utilization Pneumonia - epidemiology Pregnancy Pregnancy Complications - blood Pregnancy Complications - drug therapy Pregnancy Complications - epidemiology Pregnancy Outcome Respiration, Artificial - utilization Respiratory Distress Syndrome, Newborn - epidemiology Retrospective Studies Risk Factors Stillbirth - epidemiology Transient Tachypnea of the Newborn - epidemiology ursodeoxycholic acid Ursodeoxycholic Acid - therapeutic use Young Adult |
Title | Predictors of adverse neonatal outcomes in intrahepatic cholestasis of pregnancy |
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