A Genetic Variant of the Atrial Natriuretic Peptide Gene Is Associated With Cardiometabolic Protection in the General Community
We sought to define the cardiometabolic phenotype associated with rs5068, a genetic variant of the atrial natriuretic peptide (ANP) gene. The ANP and B-type natriuretic peptide play an important role in cardiorenal homeostasis but also exert metabolic actions. We genotyped 1,608 randomly selected re...
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| Published in | Journal of the American College of Cardiology Vol. 58; no. 6; pp. 629 - 636 |
|---|---|
| Main Authors | , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
New York, NY
Elsevier Inc
02.08.2011
Elsevier Elsevier Limited |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0735-1097 1558-3597 1558-3597 |
| DOI | 10.1016/j.jacc.2011.05.011 |
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| Abstract | We sought to define the cardiometabolic phenotype associated with rs5068, a genetic variant of the atrial natriuretic peptide (ANP) gene.
The ANP and B-type natriuretic peptide play an important role in cardiorenal homeostasis but also exert metabolic actions.
We genotyped 1,608 randomly selected residents from Olmsted County, Minnesota. Subjects were well-characterized.
Genotype frequencies were: AA 89.9%, AG 9.7%, and GG 0.4%; all subsequent analyses were AA versus AG+GG. The G allele was associated with increased plasma levels of N-terminal pro-atrial natriuretic peptide (p = 0.002), after adjustment for age and sex. The minor allele was also associated with lower body mass index (BMI) (p = 0.006), prevalence of obesity (p = 0.002), waist circumference (p = 0.021), lower levels of C-reactive protein (p = 0.027), and higher values of high-density lipoprotein cholesterol (p = 0.019). The AG+GG group had a lower systolic blood pressure (p = 0.011) and lower prevalence of myocardial infarction (p = 0.042). The minor allele was associated with a lower prevalence of metabolic syndrome (p = 0.025). The associations between the G allele and high-density lipoprotein cholesterol, C-reactive protein values, myocardial infarction, and metabolic syndrome were not significant, after adjusting for BMI; the associations with systolic blood pressure, BMI, obesity, and waist circumference remained significant even after adjusting for N-terminal pro-atrial natriuretic peptide.
In a random sample of the general U.S. population, the minor allele of rs5068 is associated with a favorable cardiometabolic profile. These findings suggest that rs5068 or genetic loci in linkage disequilibrium might affect susceptibility for cardiometabolic diseases and support the possible protective role of natriuretic peptides by their favorable effects on metabolic function. Replication studies are needed to confirm our findings. |
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| AbstractList | We sought to define the cardiometabolic phenotype associated with rs5068, a genetic variant of the atrial natriuretic peptide (ANP) gene.
The ANP and B-type natriuretic peptide play an important role in cardiorenal homeostasis but also exert metabolic actions.
We genotyped 1,608 randomly selected residents from Olmsted County, Minnesota. Subjects were well-characterized.
Genotype frequencies were: AA 89.9%, AG 9.7%, and GG 0.4%; all subsequent analyses were AA versus AG+GG. The G allele was associated with increased plasma levels of N-terminal pro-atrial natriuretic peptide (p = 0.002), after adjustment for age and sex. The minor allele was also associated with lower body mass index (BMI) (p = 0.006), prevalence of obesity (p = 0.002), waist circumference (p = 0.021), lower levels of C-reactive protein (p = 0.027), and higher values of high-density lipoprotein cholesterol (p = 0.019). The AG+GG group had a lower systolic blood pressure (p = 0.011) and lower prevalence of myocardial infarction (p = 0.042). The minor allele was associated with a lower prevalence of metabolic syndrome (p = 0.025). The associations between the G allele and high-density lipoprotein cholesterol, C-reactive protein values, myocardial infarction, and metabolic syndrome were not significant, after adjusting for BMI; the associations with systolic blood pressure, BMI, obesity, and waist circumference remained significant even after adjusting for N-terminal pro-atrial natriuretic peptide.
In a random sample of the general U.S. population, the minor allele of rs5068 is associated with a favorable cardiometabolic profile. These findings suggest that rs5068 or genetic loci in linkage disequilibrium might affect susceptibility for cardiometabolic diseases and support the possible protective role of natriuretic peptides by their favorable effects on metabolic function. Replication studies are needed to confirm our findings. OBJECTIVES: We sought to define the cardiometabolic phenotype associated with rs5068, a genetic variant of the atrial natriuretic peptide (ANP) gene. BACKGROUND: The ANP and B-type natriuretic peptide play an important role in cardiorenal homeostasis but also exert metabolic actions. METHODS: We genotyped 1,608 randomly selected residents from Olmsted County, Minnesota. Subjects were well-characterized. RESULTS: Genotype frequencies were: AA 89.9%, AG 9.7%, and GG 0.4%; all subsequent analyses were AA versus AG+GG. The G allele was associated with increased plasma levels of N-terminal pro-atrial natriuretic peptide (p = 0.002), after adjustment for age and sex. The minor allele was also associated with lower body mass index (BMI) (p = 0.006), prevalence of obesity (p = 0.002), waist circumference (p = 0.021), lower levels of C-reactive protein (p = 0.027), and higher values of high-density lipoprotein cholesterol (p = 0.019). The AG+GG group had a lower systolic blood pressure (p = 0.011) and lower prevalence of myocardial infarction (p = 0.042). The minor allele was associated with a lower prevalence of metabolic syndrome (p = 0.025). The associations between the G allele and high-density lipoprotein cholesterol, C-reactive protein values, myocardial infarction, and metabolic syndrome were not significant, after adjusting for BMI; the associations with systolic blood pressure, BMI, obesity, and waist circumference remained significant even after adjusting for N-terminal pro-atrial natriuretic peptide. CONCLUSIONS: In a random sample of the general U.S. population, the minor allele of rs5068 is associated with a favorable cardiometabolic profile. These findings suggest that rs5068 or genetic loci in linkage disequilibrium might affect susceptibility for cardiometabolic diseases and support the possible protective role of natriuretic peptides by their favorable effects on metabolic function. Replication studies are needed to confirm our findings. We sought to define the cardiometabolic phenotype associated with rs5068, a genetic variant of the atrial natriuretic peptide (ANP) gene.OBJECTIVESWe sought to define the cardiometabolic phenotype associated with rs5068, a genetic variant of the atrial natriuretic peptide (ANP) gene.The ANP and B-type natriuretic peptide play an important role in cardiorenal homeostasis but also exert metabolic actions.BACKGROUNDThe ANP and B-type natriuretic peptide play an important role in cardiorenal homeostasis but also exert metabolic actions.We genotyped 1,608 randomly selected residents from Olmsted County, Minnesota. Subjects were well-characterized.METHODSWe genotyped 1,608 randomly selected residents from Olmsted County, Minnesota. Subjects were well-characterized.Genotype frequencies were: AA 89.9%, AG 9.7%, and GG 0.4%; all subsequent analyses were AA versus AG+GG. The G allele was associated with increased plasma levels of N-terminal pro-atrial natriuretic peptide (p = 0.002), after adjustment for age and sex. The minor allele was also associated with lower body mass index (BMI) (p = 0.006), prevalence of obesity (p = 0.002), waist circumference (p = 0.021), lower levels of C-reactive protein (p = 0.027), and higher values of high-density lipoprotein cholesterol (p = 0.019). The AG+GG group had a lower systolic blood pressure (p = 0.011) and lower prevalence of myocardial infarction (p = 0.042). The minor allele was associated with a lower prevalence of metabolic syndrome (p = 0.025). The associations between the G allele and high-density lipoprotein cholesterol, C-reactive protein values, myocardial infarction, and metabolic syndrome were not significant, after adjusting for BMI; the associations with systolic blood pressure, BMI, obesity, and waist circumference remained significant even after adjusting for N-terminal pro-atrial natriuretic peptide.RESULTSGenotype frequencies were: AA 89.9%, AG 9.7%, and GG 0.4%; all subsequent analyses were AA versus AG+GG. The G allele was associated with increased plasma levels of N-terminal pro-atrial natriuretic peptide (p = 0.002), after adjustment for age and sex. The minor allele was also associated with lower body mass index (BMI) (p = 0.006), prevalence of obesity (p = 0.002), waist circumference (p = 0.021), lower levels of C-reactive protein (p = 0.027), and higher values of high-density lipoprotein cholesterol (p = 0.019). The AG+GG group had a lower systolic blood pressure (p = 0.011) and lower prevalence of myocardial infarction (p = 0.042). The minor allele was associated with a lower prevalence of metabolic syndrome (p = 0.025). The associations between the G allele and high-density lipoprotein cholesterol, C-reactive protein values, myocardial infarction, and metabolic syndrome were not significant, after adjusting for BMI; the associations with systolic blood pressure, BMI, obesity, and waist circumference remained significant even after adjusting for N-terminal pro-atrial natriuretic peptide.In a random sample of the general U.S. population, the minor allele of rs5068 is associated with a favorable cardiometabolic profile. These findings suggest that rs5068 or genetic loci in linkage disequilibrium might affect susceptibility for cardiometabolic diseases and support the possible protective role of natriuretic peptides by their favorable effects on metabolic function. Replication studies are needed to confirm our findings.CONCLUSIONSIn a random sample of the general U.S. population, the minor allele of rs5068 is associated with a favorable cardiometabolic profile. These findings suggest that rs5068 or genetic loci in linkage disequilibrium might affect susceptibility for cardiometabolic diseases and support the possible protective role of natriuretic peptides by their favorable effects on metabolic function. Replication studies are needed to confirm our findings. |
| Author | Lahr, Brian D. Olson, Timothy M. Heublein, Denise M. McKie, Paul M. Bailey, Kent R. Costello-Boerrigter, Lisa C. Burnett, John C. Cannone, Valentina Averna, Maurizio Boerrigter, Guido Cataliotti, Alessandro Rodeheffer, Richard J. Redfield, Margaret M. |
| AuthorAffiliation | Division of Biostatistics, Mayo Clinic and Mayo Clinic College of Medicine, Rochester, MN, USA Department of Clinical Medicine and Emerging Diseases, University of Palermo, Palermo, Italy Cardiorenal Research Laboratory, Division of Cardiovascular Diseases, Mayo Clinic and Mayo Clinic College of Medicine, Rochester, MN, USA Division of Cardiovascular Diseases, Mayo Clinic and Mayo Clinic College of Medicine, Rochester, MN, USA Cardiovascular Genetics Research Laboratory, Divisions of Cardiovascular Diseases and Pediatric Cardiology, Mayo Clinic and Mayo Clinic College of Medicine, Rochester, MN, USA |
| AuthorAffiliation_xml | – name: Department of Clinical Medicine and Emerging Diseases, University of Palermo, Palermo, Italy – name: Cardiovascular Genetics Research Laboratory, Divisions of Cardiovascular Diseases and Pediatric Cardiology, Mayo Clinic and Mayo Clinic College of Medicine, Rochester, MN, USA – name: Division of Biostatistics, Mayo Clinic and Mayo Clinic College of Medicine, Rochester, MN, USA – name: Division of Cardiovascular Diseases, Mayo Clinic and Mayo Clinic College of Medicine, Rochester, MN, USA – name: Cardiorenal Research Laboratory, Division of Cardiovascular Diseases, Mayo Clinic and Mayo Clinic College of Medicine, Rochester, MN, USA |
| Author_xml | – sequence: 1 givenname: Valentina surname: Cannone fullname: Cannone, Valentina email: cannone.valentina@mayo.edu organization: Cardiorenal Research Laboratory, Division of Cardiovascular Diseases, Mayo Clinic and Mayo Clinic College of Medicine, Rochester, Minnesota – sequence: 2 givenname: Guido surname: Boerrigter fullname: Boerrigter, Guido organization: Cardiorenal Research Laboratory, Division of Cardiovascular Diseases, Mayo Clinic and Mayo Clinic College of Medicine, Rochester, Minnesota – sequence: 3 givenname: Alessandro surname: Cataliotti fullname: Cataliotti, Alessandro organization: Cardiorenal Research Laboratory, Division of Cardiovascular Diseases, Mayo Clinic and Mayo Clinic College of Medicine, Rochester, Minnesota – sequence: 4 givenname: Lisa C. surname: Costello-Boerrigter fullname: Costello-Boerrigter, Lisa C. organization: Cardiorenal Research Laboratory, Division of Cardiovascular Diseases, Mayo Clinic and Mayo Clinic College of Medicine, Rochester, Minnesota – sequence: 5 givenname: Timothy M. surname: Olson fullname: Olson, Timothy M. organization: Cardiovascular Genetics Research Laboratory, Divisions of Cardiovascular Diseases and Pediatric Cardiology, Mayo Clinic and Mayo Clinic College of Medicine, Rochester, Minnesota – sequence: 6 givenname: Paul M. surname: McKie fullname: McKie, Paul M. organization: Cardiorenal Research Laboratory, Division of Cardiovascular Diseases, Mayo Clinic and Mayo Clinic College of Medicine, Rochester, Minnesota – sequence: 7 givenname: Denise M. surname: Heublein fullname: Heublein, Denise M. organization: Cardiorenal Research Laboratory, Division of Cardiovascular Diseases, Mayo Clinic and Mayo Clinic College of Medicine, Rochester, Minnesota – sequence: 8 givenname: Brian D. surname: Lahr fullname: Lahr, Brian D. organization: Division of Biostatistics, Mayo Clinic and Mayo Clinic College of Medicine, Rochester, Minnesota – sequence: 9 givenname: Kent R. surname: Bailey fullname: Bailey, Kent R. organization: Division of Biostatistics, Mayo Clinic and Mayo Clinic College of Medicine, Rochester, Minnesota – sequence: 10 givenname: Maurizio surname: Averna fullname: Averna, Maurizio organization: Department of Clinical Medicine and Emerging Diseases, University of Palermo, Palermo, Italy – sequence: 11 givenname: Margaret M. surname: Redfield fullname: Redfield, Margaret M. organization: Cardiorenal Research Laboratory, Division of Cardiovascular Diseases, Mayo Clinic and Mayo Clinic College of Medicine, Rochester, Minnesota – sequence: 12 givenname: Richard J. surname: Rodeheffer fullname: Rodeheffer, Richard J. organization: Division of Cardiovascular Diseases, Mayo Clinic and Mayo Clinic College of Medicine, Rochester, Minnesota – sequence: 13 givenname: John C. surname: Burnett fullname: Burnett, John C. organization: Cardiorenal Research Laboratory, Division of Cardiovascular Diseases, Mayo Clinic and Mayo Clinic College of Medicine, Rochester, Minnesota |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24412355$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/21798427$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1038/nm1137 10.1038/312654a0 10.1016/S0735-1097(02)02059-4 10.1016/S0735-1097(02)02981-9 10.1016/0196-9781(88)90008-3 10.1210/jc.2004-1953 10.3181/0708-RM-216 10.1093/hmg/ddm084 10.1126/science.2935937 10.1016/S0022-2275(20)31162-7 10.1210/jcem-67-3-429 10.1016/j.jacc.2009.02.037 10.1016/S0025-6196(12)61058-1 10.1038/nm724 10.1074/jbc.M303713200 10.1016/0196-9781(96)00152-0 10.2337/db09-0393 10.1001/jama.289.2.194 10.1152/ajpregu.00162.2007 10.1001/archinte.1997.00440420033005 10.1097/00005344-198611000-00005 10.1161/CIRCULATIONAHA.105.538520 10.1073/pnas.102650499 10.1161/01.CIR.37.5.800 10.1161/CIRCULATIONAHA.107.759241 10.1016/j.jacc.2005.09.025 10.1016/j.jacc.2009.02.038 10.1093/hmg/ddp169 10.1038/ng.328 10.1046/j.1523-1755.2000.00411.x 10.1016/0002-9149(87)91133-7 10.1016/j.jacc.2010.01.031 10.1016/j.tem.2006.06.006 10.1016/0024-3205(81)90370-2 10.1161/CIRCULATIONAHA.106.655142 10.1016/0006-291X(84)91077-5 |
| ContentType | Journal Article |
| Copyright | 2011 American College of Cardiology Foundation American College of Cardiology Foundation 2015 INIST-CNRS Copyright © 2011 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. Copyright Elsevier Limited Aug 2, 2011 2011 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. 2011 |
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| Keywords | CRP SBP ANP BNP lipid metabolism cGMP LV BP metabolic syndrome NT-proANP natriuretic peptides HDL NT-proBNP cardiometabolic disease SNP DNA NPPA atrial natriuretic peptide BMI C-reactive protein single nucleotide polymorphism high-density lipoprotein systolic blood pressure N-terminal pro-atrial natriuretic peptide natriuretic peptide precursor A gene deoxyribonucleic acid left ventricular blood pressure body mass index B-type natriuretic peptide 3′,5′ cyclic guanosine monophosphate N-terminal pro–B-type natriuretic peptide Gene Genetic variant Atrial natriuretic peptide Circulatory system Cardiology Protection Community |
| Language | English |
| License | http://www.elsevier.com/open-access/userlicense/1.0 https://www.elsevier.com/tdm/userlicense/1.0 CC BY 4.0 Copyright © 2011 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. |
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| References | Nemer, Chamberland, Sirois (bib5) 1984; 312 Verspohl, Bernemann (bib30) 1996; 17 McKie, Cataliotti, Lahr (bib18) 2010; 55 Shibata, Ouchi, Ito (bib11) 2004; 10 Thibault, Murthy, Gutkowska (bib28) 1988; 9 Cataliotti, Schirger, Martin (bib36) 2005; 112 Wang, Larson, Keyes, Levy, Benjamin, Vasan (bib34) 2007; 115 Miyashita, Itoh, Tsujimoto (bib14) 2009; 58 Redfield, Jacobsen, Burnett, Mahoney, Bailey, Rodeheffer (bib17) 2003; 289 Costello-Boerrigter, Boerrigter, Redfield (bib21) 2006; 47 Shub, Klein, Zachariah, Bailey, Tajik (bib22) 1994; 69 Itoh, Nakao, Sugawara (bib27) 1988; 67 Uehlinger, Weidmann, Gnadinger (bib29) 1986; 8 Sengenes, Bouloumie, Hauner (bib33) 2003; 278 Maeda, Shimomura, Kishida (bib10) 2002; 8 Garbers, Chrisman, Wiegn (bib4) 2006; 17 Costello-Boerrigter, Burnett (bib12) 2009; 53 Levy, Savage, Garrison, Anderson, Kannel, Castelli (bib25) 1987; 59 Murray, Kennedy, Figley (bib23) 1968; 37 Choquet, Cavalcanti-Proenca, Lecoeur (bib16) 2009; 18 Cataliotti, Chen, Schirger (bib35) 2008; 118 Addisu, Gower, Landon, Dietz (bib13) 2008; 233 Pritchett, Jacobsen, Mahoney, Rodeheffer, Bailey, Redfield (bib26) 2003; 41 Galitzky, Sengenes, Thalamas (bib32) 2001; 42 Holtwick, Gotthardt, Skryabin (bib3) 2002; 99 Redfield, Rodeheffer, Jacobsen, Mahoney, Bailey, Burnett (bib24) 2002; 40 Birkenfeld, Boschmann, Moro (bib8) 2005; 90 Moro, Pillard, de Glisezinski (bib31) 2007; 293 Smithies, Kim, Takahashi, Edgell (bib7) 2000; 58 Kangawa, Matsuo (bib2) 1984; 118 (bib19) 1997; 157 de Bold, Borenstein, Veress, Sonnenberg (bib1) 1981; 28 Tsukamoto, Fujita, Kato (bib9) 2009; 53 Meirhaeghe, Sandhu, McCarthy (bib15) 2007; 16 Newton-Cheh, Larson, Vasan (bib6) 2009; 41 Burnett, Kao, Hu (bib20) 1986; 231 Sengenes (10.1016/j.jacc.2011.05.011_bib33) 2003; 278 Smithies (10.1016/j.jacc.2011.05.011_bib7) 2000; 58 Addisu (10.1016/j.jacc.2011.05.011_bib13) 2008; 233 Murray (10.1016/j.jacc.2011.05.011_bib23) 1968; 37 Nemer (10.1016/j.jacc.2011.05.011_bib5) 1984; 312 Redfield (10.1016/j.jacc.2011.05.011_bib24) 2002; 40 Newton-Cheh (10.1016/j.jacc.2011.05.011_bib6) 2009; 41 Moro (10.1016/j.jacc.2011.05.011_bib31) 2007; 293 Maeda (10.1016/j.jacc.2011.05.011_bib10) 2002; 8 Pritchett (10.1016/j.jacc.2011.05.011_bib26) 2003; 41 Costello-Boerrigter (10.1016/j.jacc.2011.05.011_bib21) 2006; 47 Uehlinger (10.1016/j.jacc.2011.05.011_bib29) 1986; 8 McKie (10.1016/j.jacc.2011.05.011_bib18) 2010; 55 Wang (10.1016/j.jacc.2011.05.011_bib34) 2007; 115 Meirhaeghe (10.1016/j.jacc.2011.05.011_bib15) 2007; 16 Choquet (10.1016/j.jacc.2011.05.011_bib16) 2009; 18 Thibault (10.1016/j.jacc.2011.05.011_bib28) 1988; 9 Levy (10.1016/j.jacc.2011.05.011_bib25) 1987; 59 de Bold (10.1016/j.jacc.2011.05.011_bib1) 1981; 28 Itoh (10.1016/j.jacc.2011.05.011_bib27) 1988; 67 Verspohl (10.1016/j.jacc.2011.05.011_bib30) 1996; 17 Costello-Boerrigter (10.1016/j.jacc.2011.05.011_bib12) 2009; 53 Cataliotti (10.1016/j.jacc.2011.05.011_bib35) 2008; 118 Burnett (10.1016/j.jacc.2011.05.011_bib20) 1986; 231 Kangawa (10.1016/j.jacc.2011.05.011_bib2) 1984; 118 (10.1016/j.jacc.2011.05.011_bib19) 1997; 157 Miyashita (10.1016/j.jacc.2011.05.011_bib14) 2009; 58 Shibata (10.1016/j.jacc.2011.05.011_bib11) 2004; 10 Galitzky (10.1016/j.jacc.2011.05.011_bib32) 2001; 42 Holtwick (10.1016/j.jacc.2011.05.011_bib3) 2002; 99 Garbers (10.1016/j.jacc.2011.05.011_bib4) 2006; 17 Tsukamoto (10.1016/j.jacc.2011.05.011_bib9) 2009; 53 Cataliotti (10.1016/j.jacc.2011.05.011_bib36) 2005; 112 Birkenfeld (10.1016/j.jacc.2011.05.011_bib8) 2005; 90 Shub (10.1016/j.jacc.2011.05.011_bib22) 1994; 69 Redfield (10.1016/j.jacc.2011.05.011_bib17) 2003; 289 |
| References_xml | – volume: 40 start-page: 976 year: 2002 end-page: 982 ident: bib24 article-title: Plasma brain natriuretic peptide concentration: impact of age and gender publication-title: J Am Coll Cardiol – volume: 233 start-page: 475 year: 2008 end-page: 482 ident: bib13 article-title: B-type natriuretic peptide decreases gastric emptying and absorption publication-title: Exp Biol Med (Maywood) – volume: 59 start-page: 956 year: 1987 end-page: 960 ident: bib25 article-title: Echocardiographic criteria for left ventricular hypertrophy: the Framingham Heart Study publication-title: Am J Cardiol – volume: 112 start-page: 836 year: 2005 end-page: 840 ident: bib36 article-title: Oral human brain natriuretic peptide activates cyclic guanosine 3′,5′-monophosphate and decreases mean arterial pressure publication-title: Circulation – volume: 41 start-page: 1036 year: 2003 end-page: 1043 ident: bib26 article-title: Left atrial volume as an index of left atrial size: a population-based study publication-title: J Am Coll Cardiol – volume: 115 start-page: 1345 year: 2007 end-page: 1353 ident: bib34 article-title: Association of plasma natriuretic peptide levels with metabolic risk factors in ambulatory individuals publication-title: Circulation – volume: 118 start-page: 1729 year: 2008 end-page: 1736 ident: bib35 article-title: Chronic actions of a novel oral B-type natriuretic peptide conjugate in normal dogs and acute actions in angiotensin II-mediated hypertension publication-title: Circulation – volume: 67 start-page: 429 year: 1988 end-page: 437 ident: bib27 article-title: Gamma-atrial natriuretic polypeptide (gamma ANP)-derived peptides in human plasma: cosecretion of N-terminal gamma ANP fragment and alpha ANP publication-title: J Clin Endocrinol Metab – volume: 312 start-page: 654 year: 1984 end-page: 656 ident: bib5 article-title: Gene structure of human cardiac hormone precursor, pronatriodilatin publication-title: Nature – volume: 16 start-page: 1343 year: 2007 end-page: 1350 ident: bib15 article-title: Association between the T-381C polymorphism of the brain natriuretic peptide gene and risk of type 2 diabetes in human populations publication-title: Hum Mol Genet – volume: 289 start-page: 194 year: 2003 end-page: 202 ident: bib17 article-title: Burden of systolic and diastolic ventricular dysfunction in the community: appreciating the scope of the heart failure epidemic publication-title: JAMA – volume: 37 start-page: 800 year: 1968 end-page: 804 ident: bib23 article-title: Quantitative angiocardiography publication-title: Circulation – volume: 118 start-page: 131 year: 1984 end-page: 139 ident: bib2 article-title: Purification and complete amino acid sequence of alpha-human atrial natriuretic polypeptide (alpha-hANP) publication-title: Biochem Biophys Res Commun – volume: 293 start-page: R612 year: 2007 end-page: R617 ident: bib31 article-title: Atrial natriuretic peptide contribution to lipid mobilization and utilization during head-down bed rest in humans publication-title: Am J Physiol Regul Integr Comp Physiol – volume: 157 start-page: 2413 year: 1997 end-page: 2446 ident: bib19 article-title: The sixth report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure publication-title: Arch Intern Med – volume: 47 start-page: 345 year: 2006 end-page: 353 ident: bib21 article-title: Amino-terminal pro-B-type natriuretic peptide and B-type natriuretic peptide in the general community: determinants and detection of left ventricular dysfunction publication-title: J Am Coll Cardiol – volume: 41 start-page: 348 year: 2009 end-page: 353 ident: bib6 article-title: Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure publication-title: Nat Genet – volume: 28 start-page: 89 year: 1981 end-page: 94 ident: bib1 article-title: A rapid and potent natriuretic response to intravenous injection of atrial myocardial extract in rats publication-title: Life Sci – volume: 55 start-page: 2140 year: 2010 end-page: 2147 ident: bib18 article-title: The prognostic value of N-terminal pro–B-type natriuretic peptide for death and cardiovascular events in healthy normal and stage A/B heart failure subjects publication-title: J Am Coll Cardiol – volume: 17 start-page: 1023 year: 1996 end-page: 1029 ident: bib30 article-title: Atrial natriuretic peptide (ANP)-induced inhibition of glucagon secretion: mechanism of action in isolated rat pancreatic islets publication-title: Peptides – volume: 53 start-page: 2078 year: 2009 end-page: 2079 ident: bib12 article-title: A new role for the natriuretic peptides: metabolic regulators of the adipocyte publication-title: J Am Coll Cardiol – volume: 17 start-page: 251 year: 2006 end-page: 258 ident: bib4 article-title: Membrane guanylyl cyclase receptors: an update publication-title: Trends Endocrinol Metab – volume: 53 start-page: 2070 year: 2009 end-page: 2077 ident: bib9 article-title: Natriuretic peptides enhance the production of adiponectin in human adipocytes and in patients with chronic heart failure publication-title: J Am Coll Cardiol – volume: 10 start-page: 1384 year: 2004 end-page: 1389 ident: bib11 article-title: Adiponectin-mediated modulation of hypertrophic signals in the heart publication-title: Nat Med – volume: 18 start-page: 2495 year: 2009 end-page: 2501 ident: bib16 article-title: The T-381C SNP in BNP gene may be modestly associated with type 2 diabetes: an updated meta-analysis in 49 279 subjects publication-title: Hum Mol Genet – volume: 99 start-page: 7142 year: 2002 end-page: 7147 ident: bib3 article-title: Smooth muscle-selective deletion of guanylyl cyclase-A prevents the acute but not chronic effects of ANP on blood pressure publication-title: Proc Natl Acad Sci U S A – volume: 69 start-page: 205 year: 1994 end-page: 211 ident: bib22 article-title: Determination of left ventricular mass by echocardiography in a normal population: effect of age and sex in addition to body size publication-title: Mayo Clin Proc – volume: 9 start-page: 47 year: 1988 end-page: 53 ident: bib28 article-title: NH2-terminal fragment of rat pro-atrial natriuretic factor in the circulation: identification, radioimmunoassay and half-life publication-title: Peptides – volume: 8 start-page: 731 year: 2002 end-page: 737 ident: bib10 article-title: Diet-induced insulin resistance in mice lacking adiponectin/ACRP30 publication-title: Nat Med – volume: 231 start-page: 1145 year: 1986 end-page: 1147 ident: bib20 article-title: Atrial natriuretic peptide elevation in congestive heart failure in the human publication-title: Science – volume: 8 start-page: 1122 year: 1986 end-page: 1129 ident: bib29 article-title: Increase in circulating insulin induced by atrial natriuretic peptide in normal humans publication-title: J Cardiovasc Pharmacol – volume: 58 start-page: 2265 year: 2000 end-page: 2280 ident: bib7 article-title: Importance of quantitative genetic variations in the etiology of hypertension publication-title: Kidney Int – volume: 42 start-page: 536 year: 2001 end-page: 544 ident: bib32 article-title: The lipid-mobilizing effect of atrial natriuretic peptide is unrelated to sympathetic nervous system activation or obesity in young men publication-title: J Lipid Res – volume: 90 start-page: 3622 year: 2005 end-page: 3628 ident: bib8 article-title: Lipid mobilization with physiological atrial natriuretic peptide concentrations in humans publication-title: J Clin Endocrinol Metab – volume: 58 start-page: 2880 year: 2009 end-page: 2892 ident: bib14 article-title: Natriuretic peptides/cGMP/cGMP-dependent protein kinase cascades promote muscle mitochondrial biogenesis and prevent obesity publication-title: Diabetes – volume: 278 start-page: 48617 year: 2003 end-page: 48626 ident: bib33 article-title: Involvement of a cGMP-dependent pathway in the natriuretic peptide-mediated hormone-sensitive lipase phosphorylation in human adipocytes publication-title: J Biol Chem – volume: 10 start-page: 1384 year: 2004 ident: 10.1016/j.jacc.2011.05.011_bib11 article-title: Adiponectin-mediated modulation of hypertrophic signals in the heart publication-title: Nat Med doi: 10.1038/nm1137 – volume: 312 start-page: 654 year: 1984 ident: 10.1016/j.jacc.2011.05.011_bib5 article-title: Gene structure of human cardiac hormone precursor, pronatriodilatin publication-title: Nature doi: 10.1038/312654a0 – volume: 40 start-page: 976 year: 2002 ident: 10.1016/j.jacc.2011.05.011_bib24 article-title: Plasma brain natriuretic peptide concentration: impact of age and gender publication-title: J Am Coll Cardiol doi: 10.1016/S0735-1097(02)02059-4 – volume: 41 start-page: 1036 year: 2003 ident: 10.1016/j.jacc.2011.05.011_bib26 article-title: Left atrial volume as an index of left atrial size: a population-based study publication-title: J Am Coll Cardiol doi: 10.1016/S0735-1097(02)02981-9 – volume: 9 start-page: 47 year: 1988 ident: 10.1016/j.jacc.2011.05.011_bib28 article-title: NH2-terminal fragment of rat pro-atrial natriuretic factor in the circulation: identification, radioimmunoassay and half-life publication-title: Peptides doi: 10.1016/0196-9781(88)90008-3 – volume: 90 start-page: 3622 year: 2005 ident: 10.1016/j.jacc.2011.05.011_bib8 article-title: Lipid mobilization with physiological atrial natriuretic peptide concentrations in humans publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2004-1953 – volume: 233 start-page: 475 year: 2008 ident: 10.1016/j.jacc.2011.05.011_bib13 article-title: B-type natriuretic peptide decreases gastric emptying and absorption publication-title: Exp Biol Med (Maywood) doi: 10.3181/0708-RM-216 – volume: 16 start-page: 1343 year: 2007 ident: 10.1016/j.jacc.2011.05.011_bib15 article-title: Association between the T-381C polymorphism of the brain natriuretic peptide gene and risk of type 2 diabetes in human populations publication-title: Hum Mol Genet doi: 10.1093/hmg/ddm084 – volume: 231 start-page: 1145 year: 1986 ident: 10.1016/j.jacc.2011.05.011_bib20 article-title: Atrial natriuretic peptide elevation in congestive heart failure in the human publication-title: Science doi: 10.1126/science.2935937 – volume: 42 start-page: 536 year: 2001 ident: 10.1016/j.jacc.2011.05.011_bib32 article-title: The lipid-mobilizing effect of atrial natriuretic peptide is unrelated to sympathetic nervous system activation or obesity in young men publication-title: J Lipid Res doi: 10.1016/S0022-2275(20)31162-7 – volume: 67 start-page: 429 year: 1988 ident: 10.1016/j.jacc.2011.05.011_bib27 article-title: Gamma-atrial natriuretic polypeptide (gamma ANP)-derived peptides in human plasma: cosecretion of N-terminal gamma ANP fragment and alpha ANP publication-title: J Clin Endocrinol Metab doi: 10.1210/jcem-67-3-429 – volume: 53 start-page: 2078 year: 2009 ident: 10.1016/j.jacc.2011.05.011_bib12 article-title: A new role for the natriuretic peptides: metabolic regulators of the adipocyte publication-title: J Am Coll Cardiol doi: 10.1016/j.jacc.2009.02.037 – volume: 69 start-page: 205 year: 1994 ident: 10.1016/j.jacc.2011.05.011_bib22 article-title: Determination of left ventricular mass by echocardiography in a normal population: effect of age and sex in addition to body size publication-title: Mayo Clin Proc doi: 10.1016/S0025-6196(12)61058-1 – volume: 8 start-page: 731 year: 2002 ident: 10.1016/j.jacc.2011.05.011_bib10 article-title: Diet-induced insulin resistance in mice lacking adiponectin/ACRP30 publication-title: Nat Med doi: 10.1038/nm724 – volume: 278 start-page: 48617 year: 2003 ident: 10.1016/j.jacc.2011.05.011_bib33 article-title: Involvement of a cGMP-dependent pathway in the natriuretic peptide-mediated hormone-sensitive lipase phosphorylation in human adipocytes publication-title: J Biol Chem doi: 10.1074/jbc.M303713200 – volume: 17 start-page: 1023 year: 1996 ident: 10.1016/j.jacc.2011.05.011_bib30 article-title: Atrial natriuretic peptide (ANP)-induced inhibition of glucagon secretion: mechanism of action in isolated rat pancreatic islets publication-title: Peptides doi: 10.1016/0196-9781(96)00152-0 – volume: 58 start-page: 2880 year: 2009 ident: 10.1016/j.jacc.2011.05.011_bib14 article-title: Natriuretic peptides/cGMP/cGMP-dependent protein kinase cascades promote muscle mitochondrial biogenesis and prevent obesity publication-title: Diabetes doi: 10.2337/db09-0393 – volume: 289 start-page: 194 year: 2003 ident: 10.1016/j.jacc.2011.05.011_bib17 article-title: Burden of systolic and diastolic ventricular dysfunction in the community: appreciating the scope of the heart failure epidemic publication-title: JAMA doi: 10.1001/jama.289.2.194 – volume: 293 start-page: R612 year: 2007 ident: 10.1016/j.jacc.2011.05.011_bib31 article-title: Atrial natriuretic peptide contribution to lipid mobilization and utilization during head-down bed rest in humans publication-title: Am J Physiol Regul Integr Comp Physiol doi: 10.1152/ajpregu.00162.2007 – volume: 157 start-page: 2413 year: 1997 ident: 10.1016/j.jacc.2011.05.011_bib19 article-title: The sixth report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure publication-title: Arch Intern Med doi: 10.1001/archinte.1997.00440420033005 – volume: 8 start-page: 1122 year: 1986 ident: 10.1016/j.jacc.2011.05.011_bib29 article-title: Increase in circulating insulin induced by atrial natriuretic peptide in normal humans publication-title: J Cardiovasc Pharmacol doi: 10.1097/00005344-198611000-00005 – volume: 112 start-page: 836 year: 2005 ident: 10.1016/j.jacc.2011.05.011_bib36 article-title: Oral human brain natriuretic peptide activates cyclic guanosine 3′,5′-monophosphate and decreases mean arterial pressure publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.105.538520 – volume: 99 start-page: 7142 year: 2002 ident: 10.1016/j.jacc.2011.05.011_bib3 article-title: Smooth muscle-selective deletion of guanylyl cyclase-A prevents the acute but not chronic effects of ANP on blood pressure publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.102650499 – volume: 37 start-page: 800 year: 1968 ident: 10.1016/j.jacc.2011.05.011_bib23 article-title: Quantitative angiocardiography publication-title: Circulation doi: 10.1161/01.CIR.37.5.800 – volume: 118 start-page: 1729 year: 2008 ident: 10.1016/j.jacc.2011.05.011_bib35 article-title: Chronic actions of a novel oral B-type natriuretic peptide conjugate in normal dogs and acute actions in angiotensin II-mediated hypertension publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.107.759241 – volume: 47 start-page: 345 year: 2006 ident: 10.1016/j.jacc.2011.05.011_bib21 article-title: Amino-terminal pro-B-type natriuretic peptide and B-type natriuretic peptide in the general community: determinants and detection of left ventricular dysfunction publication-title: J Am Coll Cardiol doi: 10.1016/j.jacc.2005.09.025 – volume: 53 start-page: 2070 year: 2009 ident: 10.1016/j.jacc.2011.05.011_bib9 article-title: Natriuretic peptides enhance the production of adiponectin in human adipocytes and in patients with chronic heart failure publication-title: J Am Coll Cardiol doi: 10.1016/j.jacc.2009.02.038 – volume: 18 start-page: 2495 year: 2009 ident: 10.1016/j.jacc.2011.05.011_bib16 article-title: The T-381C SNP in BNP gene may be modestly associated with type 2 diabetes: an updated meta-analysis in 49 279 subjects publication-title: Hum Mol Genet doi: 10.1093/hmg/ddp169 – volume: 41 start-page: 348 year: 2009 ident: 10.1016/j.jacc.2011.05.011_bib6 article-title: Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure publication-title: Nat Genet doi: 10.1038/ng.328 – volume: 58 start-page: 2265 year: 2000 ident: 10.1016/j.jacc.2011.05.011_bib7 article-title: Importance of quantitative genetic variations in the etiology of hypertension publication-title: Kidney Int doi: 10.1046/j.1523-1755.2000.00411.x – volume: 59 start-page: 956 year: 1987 ident: 10.1016/j.jacc.2011.05.011_bib25 article-title: Echocardiographic criteria for left ventricular hypertrophy: the Framingham Heart Study publication-title: Am J Cardiol doi: 10.1016/0002-9149(87)91133-7 – volume: 55 start-page: 2140 year: 2010 ident: 10.1016/j.jacc.2011.05.011_bib18 article-title: The prognostic value of N-terminal pro–B-type natriuretic peptide for death and cardiovascular events in healthy normal and stage A/B heart failure subjects publication-title: J Am Coll Cardiol doi: 10.1016/j.jacc.2010.01.031 – volume: 17 start-page: 251 year: 2006 ident: 10.1016/j.jacc.2011.05.011_bib4 article-title: Membrane guanylyl cyclase receptors: an update publication-title: Trends Endocrinol Metab doi: 10.1016/j.tem.2006.06.006 – volume: 28 start-page: 89 year: 1981 ident: 10.1016/j.jacc.2011.05.011_bib1 article-title: A rapid and potent natriuretic response to intravenous injection of atrial myocardial extract in rats publication-title: Life Sci doi: 10.1016/0024-3205(81)90370-2 – volume: 115 start-page: 1345 year: 2007 ident: 10.1016/j.jacc.2011.05.011_bib34 article-title: Association of plasma natriuretic peptide levels with metabolic risk factors in ambulatory individuals publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.106.655142 – volume: 118 start-page: 131 year: 1984 ident: 10.1016/j.jacc.2011.05.011_bib2 article-title: Purification and complete amino acid sequence of alpha-human atrial natriuretic polypeptide (alpha-hANP) publication-title: Biochem Biophys Res Commun doi: 10.1016/0006-291X(84)91077-5 |
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| Snippet | We sought to define the cardiometabolic phenotype associated with rs5068, a genetic variant of the atrial natriuretic peptide (ANP) gene.
The ANP and B-type... Objectives We sought to define the cardiometabolic phenotype associated with rs5068, a genetic variant of the atrial natriuretic peptide (ANP) gene. Background... We sought to define the cardiometabolic phenotype associated with rs5068, a genetic variant of the atrial natriuretic peptide (ANP) gene.OBJECTIVESWe sought to... OBJECTIVES: We sought to define the cardiometabolic phenotype associated with rs5068, a genetic variant of the atrial natriuretic peptide (ANP) gene.... |
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| SubjectTerms | Age Aged Alleles Atrial Natriuretic Factor - genetics atrial natriuretic peptide Biological and medical sciences Blood Pressure body mass Body Mass Index Cardiology Cardiology. Vascular system cardiometabolic disease Cardiovascular Cardiovascular disease Cholesterol Deoxyribonucleic acid Diabetes DNA DNA - metabolism Echocardiography, Doppler - methods Female Genetic Variation Genotype Genotype & phenotype Genotypes Glucose Heart attacks Heart failure Homeostasis Humans Hypertension Internal Medicine Kinases lipid metabolism Lipoproteins Male Medical sciences metabolic disorders metabolic syndrome Middle Aged myocardial infarction Natriuretic Peptide, Brain - genetics natriuretic peptides obesity Peptides Phenotype Population Protein Structure, Tertiary Proteins Random Allocation Rodents Software Studies |
| Title | A Genetic Variant of the Atrial Natriuretic Peptide Gene Is Associated With Cardiometabolic Protection in the General Community |
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