Repressive chromatin modification underpins the long-term expression trend of a perennial flowering gene in nature

Natural environments require organisms to possess robust mechanisms allowing responses to seasonal trends. In Arabidopsis halleri , the flowering regulator AhgFLC shows upregulation and downregulation phases along with long-term past temperature, but the underlying machinery remains elusive. Here, w...

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Published inNature communications Vol. 11; no. 1; pp. 2065 - 12
Main Authors Nishio, Haruki, Buzas, Diana M., Nagano, Atsushi J., Iwayama, Koji, Ushio, Masayuki, Kudoh, Hiroshi
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.05.2020
Nature Publishing Group
Nature Portfolio
Subjects
38/15
38/39
38/77
38/90
631/208/176
631/449/1659
631/449/2668
631/449/2679/2681
Arabidopsis - genetics
Arabidopsis - physiology
Arabidopsis Proteins - genetics
Chromatin
Chromatin - chemistry
Epigenesis, Genetic
Flowering
Flowers - genetics
Flowers - physiology
Gene expression
Gene Expression Regulation, Plant
Histone Code
Histones
Histones - metabolism
Humanities and Social Sciences
Japan
Life cycles
MADS Domain Proteins - genetics
multidisciplinary
Natural environment
Science
Science (multidisciplinary)
Seasonal variations
Seasons
Temperature
Trends
Japan
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Abstract Natural environments require organisms to possess robust mechanisms allowing responses to seasonal trends. In Arabidopsis halleri , the flowering regulator AhgFLC shows upregulation and downregulation phases along with long-term past temperature, but the underlying machinery remains elusive. Here, we investigate the seasonal dynamics of histone modifications, H3K27me3 and H3K4me3, at AhgFLC in a natural population. Our advanced modelling and transplant experiments reveal that H3K27me3-mediated chromatin regulation at AhgFLC provides two essential properties. One is the ability to respond to the long-term temperature trends via bidirectional interactions between H3K27me3 and H3K4me3; the other is the ratchet-like character of the AhgFLC system, i.e. reversible in the entire perennial life cycle but irreversible during the upregulation phase. Furthermore, we show that the long-term temperature trends are locally indexed at AhgFLC in the form of histone modifications. Our study provides a more comprehensive understanding of H3K27me3 function at AhgFLC in a complex natural environment. The flowering regulator FLC shows upregulation and downregulation phases along with long-term past temperature in Arabidopsis halleri . Here, the authors reveal that H3K27me3-mediated chromatin regulation at AhgFLC provides the ability to respond to both the seasonal temperature trends and the perennial life cycle.
AbstractList Natural environments require organisms to possess robust mechanisms allowing responses to seasonal trends. In Arabidopsis halleri, the flowering regulator AhgFLC shows upregulation and downregulation phases along with long-term past temperature, but the underlying machinery remains elusive. Here, we investigate the seasonal dynamics of histone modifications, H3K27me3 and H3K4me3, at AhgFLC in a natural population. Our advanced modelling and transplant experiments reveal that H3K27me3-mediated chromatin regulation at AhgFLC provides two essential properties. One is the ability to respond to the long-term temperature trends via bidirectional interactions between H3K27me3 and H3K4me3; the other is the ratchet-like character of the AhgFLC system, i.e. reversible in the entire perennial life cycle but irreversible during the upregulation phase. Furthermore, we show that the long-term temperature trends are locally indexed at AhgFLC in the form of histone modifications. Our study provides a more comprehensive understanding of H3K27me3 function at AhgFLC in a complex natural environment.
The flowering regulator FLC shows upregulation and downregulation phases along with long-term past temperature in Arabidopsis halleri. Here, the authors reveal that H3K27me3-mediated chromatin regulation at AhgFLC provides the ability to respond to both the seasonal temperature trends and the perennial life cycle.
Natural environments require organisms to possess robust mechanisms allowing responses to seasonal trends. In Arabidopsis halleri , the flowering regulator AhgFLC shows upregulation and downregulation phases along with long-term past temperature, but the underlying machinery remains elusive. Here, we investigate the seasonal dynamics of histone modifications, H3K27me3 and H3K4me3, at AhgFLC in a natural population. Our advanced modelling and transplant experiments reveal that H3K27me3-mediated chromatin regulation at AhgFLC provides two essential properties. One is the ability to respond to the long-term temperature trends via bidirectional interactions between H3K27me3 and H3K4me3; the other is the ratchet-like character of the AhgFLC system, i.e. reversible in the entire perennial life cycle but irreversible during the upregulation phase. Furthermore, we show that the long-term temperature trends are locally indexed at AhgFLC in the form of histone modifications. Our study provides a more comprehensive understanding of H3K27me3 function at AhgFLC in a complex natural environment.
Natural environments require organisms to possess robust mechanisms allowing responses to seasonal trends. In Arabidopsis halleri , the flowering regulator AhgFLC shows upregulation and downregulation phases along with long-term past temperature, but the underlying machinery remains elusive. Here, we investigate the seasonal dynamics of histone modifications, H3K27me3 and H3K4me3, at AhgFLC in a natural population. Our advanced modelling and transplant experiments reveal that H3K27me3-mediated chromatin regulation at AhgFLC provides two essential properties. One is the ability to respond to the long-term temperature trends via bidirectional interactions between H3K27me3 and H3K4me3; the other is the ratchet-like character of the AhgFLC system, i.e. reversible in the entire perennial life cycle but irreversible during the upregulation phase. Furthermore, we show that the long-term temperature trends are locally indexed at AhgFLC in the form of histone modifications. Our study provides a more comprehensive understanding of H3K27me3 function at AhgFLC in a complex natural environment. The flowering regulator FLC shows upregulation and downregulation phases along with long-term past temperature in Arabidopsis halleri . Here, the authors reveal that H3K27me3-mediated chromatin regulation at AhgFLC provides the ability to respond to both the seasonal temperature trends and the perennial life cycle.
Natural environments require organisms to possess robust mechanisms allowing responses to seasonal trends. In Arabidopsis halleri, the flowering regulator AhgFLC shows upregulation and downregulation phases along with long-term past temperature, but the underlying machinery remains elusive. Here, we investigate the seasonal dynamics of histone modifications, H3K27me3 and H3K4me3, at AhgFLC in a natural population. Our advanced modelling and transplant experiments reveal that H3K27me3-mediated chromatin regulation at AhgFLC provides two essential properties. One is the ability to respond to the long-term temperature trends via bidirectional interactions between H3K27me3 and H3K4me3; the other is the ratchet-like character of the AhgFLC system, i.e. reversible in the entire perennial life cycle but irreversible during the upregulation phase. Furthermore, we show that the long-term temperature trends are locally indexed at AhgFLC in the form of histone modifications. Our study provides a more comprehensive understanding of H3K27me3 function at AhgFLC in a complex natural environment.Natural environments require organisms to possess robust mechanisms allowing responses to seasonal trends. In Arabidopsis halleri, the flowering regulator AhgFLC shows upregulation and downregulation phases along with long-term past temperature, but the underlying machinery remains elusive. Here, we investigate the seasonal dynamics of histone modifications, H3K27me3 and H3K4me3, at AhgFLC in a natural population. Our advanced modelling and transplant experiments reveal that H3K27me3-mediated chromatin regulation at AhgFLC provides two essential properties. One is the ability to respond to the long-term temperature trends via bidirectional interactions between H3K27me3 and H3K4me3; the other is the ratchet-like character of the AhgFLC system, i.e. reversible in the entire perennial life cycle but irreversible during the upregulation phase. Furthermore, we show that the long-term temperature trends are locally indexed at AhgFLC in the form of histone modifications. Our study provides a more comprehensive understanding of H3K27me3 function at AhgFLC in a complex natural environment.
Natural environments require organisms to possess robust mechanisms allowing responses to seasonal trends. In Arabidopsis halleri, the flowering regulator AhgFLC shows upregulation and downregulation phases along with long-term past temperature, but the underlying machinery remains elusive. Here, we investigate the seasonal dynamics of histone modifications, H3K27me3 and H3K4me3, at AhgFLC in a natural population. Our advanced modelling and transplant experiments reveal that H3K27me3-mediated chromatin regulation at AhgFLC provides two essential properties. One is the ability to respond to the long-term temperature trends via bidirectional interactions between H3K27me3 and H3K4me3; the other is the ratchet-like character of the AhgFLC system, i.e. reversible in the entire perennial life cycle but irreversible during the upregulation phase. Furthermore, we show that the long-term temperature trends are locally indexed at AhgFLC in the form of histone modifications. Our study provides a more comprehensive understanding of H3K27me3 function at AhgFLC in a complex natural environment.The flowering regulator FLC shows upregulation and downregulation phases along with long-term past temperature in Arabidopsishalleri. Here, the authors reveal that H3K27me3-mediated chromatin regulation at AhgFLC provides the ability to respond to both the seasonal temperature trends and the perennial life cycle.
ArticleNumber 2065
Author Buzas, Diana M.
Nagano, Atsushi J.
Nishio, Haruki
Iwayama, Koji
Ushio, Masayuki
Kudoh, Hiroshi
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PublicationDecade 2020
PublicationPlace London
PublicationPlace_xml – name: London
– name: England
PublicationTitle Nature communications
PublicationTitleAbbrev Nat Commun
PublicationTitleAlternate Nat Commun
PublicationYear 2020
Publisher Nature Publishing Group UK
Nature Publishing Group
Nature Portfolio
Publisher_xml – name: Nature Publishing Group UK
– name: Nature Publishing Group
– name: Nature Portfolio
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M Ushio (15896_CR59) 2018; 554
RL Antoniou-Kourounioti (15896_CR4) 2018; 7
15896_CR34
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L Castaings (15896_CR24) 2014; 5
M Ngollo (15896_CR53) 2017; 17
S Rosa (15896_CR17) 2016; 7
AC Wollenberg (15896_CR11) 2012; 35
S Berry (15896_CR29) 2017; 4
S Sung (15896_CR19) 2004; 427
A Satake (15896_CR43) 2012; 302
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Y Kotake (15896_CR51) 2007; 21
H Nishio (15896_CR30) 2016; 91
ER Deyle (15896_CR58) 2016; 113
AE BozorgMagham (15896_CR38) 2015; 10
S Aikawa (15896_CR10) 2010; 107
R Wang (15896_CR8) 2009; 459
Y Kondo (15896_CR52) 2008; 40
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Snippet Natural environments require organisms to possess robust mechanisms allowing responses to seasonal trends. In Arabidopsis halleri , the flowering regulator...
Natural environments require organisms to possess robust mechanisms allowing responses to seasonal trends. In Arabidopsis halleri, the flowering regulator...
The flowering regulator FLC shows upregulation and downregulation phases along with long-term past temperature in Arabidopsis halleri. Here, the authors reveal...
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SubjectTerms 38/15
38/39
38/77
38/90
631/208/176
631/449/1659
631/449/2668
631/449/2679/2681
Arabidopsis - genetics
Arabidopsis - physiology
Arabidopsis Proteins - genetics
Chromatin
Chromatin - chemistry
Epigenesis, Genetic
Flowering
Flowers - genetics
Flowers - physiology
Gene expression
Gene Expression Regulation, Plant
Histone Code
Histones
Histones - metabolism
Humanities and Social Sciences
Japan
Life cycles
MADS Domain Proteins - genetics
multidisciplinary
Natural environment
Science
Science (multidisciplinary)
Seasonal variations
Seasons
Temperature
Trends
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Title Repressive chromatin modification underpins the long-term expression trend of a perennial flowering gene in nature
URI https://link.springer.com/article/10.1038/s41467-020-15896-4
https://www.ncbi.nlm.nih.gov/pubmed/32358518
https://www.proquest.com/docview/2397226910
https://www.proquest.com/docview/2397668472
https://pubmed.ncbi.nlm.nih.gov/PMC7195410
https://doaj.org/article/d34f94fc1b5a48d691c0b728b95b52fe
Volume 11
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