Pulmonary PET imaging confirms preferential lung target occupancy of an inhaled bronchodilator

• Published in: EJNMMI research Vol. 9; no. 1; pp. 9 - 10
• Main Authors: Schou, Magnus, Ewing, Pär, Cselenyi, Zsolt, Fridén, Markus, Takano, Akihiro, Halldin, Christer, Farde, Lars
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 29.01.2019; Springer Nature B.V; SpringerOpen
• Subjects: Binding; Bronchodilators; Cardiac Imaging; Field of view; Imaging; Intravenous infusion; Ipratropium; Lungs; Medical imaging; Medicine; Medicine & Public Health; Muscarinic receptors; Nuclear Medicine; Oncology; Original Research; Orthopedics; PET; Pituitary gland; Positron emission; Primates; Radiology; Receptors; Respiration; Tomography; Ipratropium; Lungs; Muscarinic receptors; PET

Background Positron emission tomography (PET) is a non-invasive molecular imaging technique that traces the distribution of radiolabeled molecules in experimental animals and human subjects. We hypothesized that PET could be used to visualize the binding of the bronchodilator drug ipratropium to mus...