A novel nairovirus associated with acute febrile illness in Hokkaido, Japan

• Published in: Nature communications Vol. 12; no. 1; pp. 5539 - 9
• Main Authors: Kodama, Fumihiro, Yamaguchi, Hiroki, Park, Eunsil, Tatemoto, Kango, Sashika, Mariko, Nakao, Ryo, Terauchi, Yurino, Mizuma, Keita, Orba, Yasuko, Kariwa, Hiroaki, Hagiwara, Katsuro, Okazaki, Katsunori, Goto, Akiko, Komagome, Rika, Miyoshi, Masahiro, Ito, Takuya, Yamano, Kimiaki, Yoshii, Kentaro, Funaki, Chiaki, Ishizuka, Mariko, Shigeno, Asako, Itakura, Yukari, Bell-Sakyi, Lesley, Edagawa, Shunji, Nagasaka, Atsushi, Sakoda, Yoshihiro, Sawa, Hirofumi, Maeda, Ken, Saijo, Masayuki, Matsuno, Keita
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 20.09.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 14/63; 38/90; 631/326/596/2555; 631/326/596/2564; 692/1807/1490; 692/699/255/2514; Adult; Animals; Antibodies; Antibodies, Viral - blood; Antibodies, Viral - immunology; Arachnids; Crimean hemorrhagic fever; Fever - blood; Fever - epidemiology; Fever - virology; Genome, Viral; Hemorrhage; Humanities and Social Sciences; Humans; Illnesses; Insect bites; Ixodes - virology; Japan - epidemiology; Leukocyte Count; Leukopenia; Male; Middle Aged; multidisciplinary; Nairovirus - genetics; Nairovirus - immunology; Nairovirus - physiology; Nairovirus - ultrastructure; Phylogeny; Public health; RNA, Viral - genetics; Science; Science (multidisciplinary); Thrombocytopenia; Ticks; Virion - ultrastructure; Viruses; Wildlife; Japan

The increasing burden of tick-borne orthonairovirus infections, such as Crimean-Congo hemorrhagic fever, is becoming a global concern for public health. In the present study, we identify a novel orthonairovirus, designated Yezo virus (YEZV), from two patients showing acute febrile illness with throm...