Development of a highly specific serodiagnostic ELISA for West Nile virus infection using subviral particles

• Published in: Scientific reports Vol. 11; no. 1; pp. 9213 - 10
• Main Authors: Maezono, Keisuke, Kobayashi, Shintaro, Tabata, Koshiro, Yoshii, Kentaro, Kariwa, Hiroaki
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 28.04.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 631/326/596/1879; 631/326/596/2562; Antigenicity; Cross-reactivity; E protein; Encephalitis; Enzyme-linked immunosorbent assay; Horses; Humanities and Social Sciences; multidisciplinary; Neutralization; PrM protein; Proteins; Science; Science (multidisciplinary); Vector-borne diseases; Viruses; West Nile virus

West Nile virus (WNV), a member of the Japanese encephalitis virus (JEV) serocomplex group, causes lethal encephalitis in humans and horses. Because serodiagnosis of WNV and JEV is hampered by cross-reactivity, the development of a simple, secure, and WNV-specific serodiagnostic system is required....