TRPC6 counteracts TRPC3-Nox2 protein complex leading to attenuation of hyperglycemia-induced heart failure in mice

• Published in: Scientific reports Vol. 7; no. 1; pp. 7511 - 14
• Main Authors: Oda, Sayaka, Numaga-Tomita, Takuro, Kitajima, Naoyuki, Toyama, Takashi, Harada, Eri, Shimauchi, Tsukasa, Nishimura, Akiyuki, Ishikawa, Tatsuya, Kumagai, Yoshito, Birnbaumer, Lutz, Nishida, Motohiro
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 08.08.2017; Nature Publishing Group; Nature Portfolio
• Subjects: 13/95; 14; 14/1; 14/19; 14/34; 38/89; 38/90; 59; 631/443/592/75/230; 631/80/304; 82/29; 82/58; Animals; Aorta; Cardiomyocytes; CYBB protein; Cytokines; Diabetes Mellitus, Experimental - chemically induced; Diabetes Mellitus, Experimental - complications; Diabetes Mellitus, Experimental - genetics; Diabetes Mellitus, Experimental - metabolism; Diglycerides; Fibrosis; Gene Expression Regulation; Heart diseases; Heart failure; Heart Failure - etiology; Heart Failure - genetics; Heart Failure - metabolism; Heart Failure - pathology; Humanities and Social Sciences; Hyperglycemia; Hyperglycemia - chemically induced; Hyperglycemia - complications; Hyperglycemia - genetics; Hyperglycemia - metabolism; Inflammation; Lipid Peroxides - metabolism; Mice; Mice, Knockout; multidisciplinary; Muscle contraction; Myocardial Contraction; Myocardium - metabolism; Myocardium - pathology; Myocytes, Cardiac - metabolism; Myocytes, Cardiac - pathology; NAD(P)H oxidase; NADPH Oxidase 2 - genetics; NADPH Oxidase 2 - metabolism; Peroxide; Pressure; Primary Cell Culture; Protein Binding; Rats; Reactive oxygen species; Reactive Oxygen Species - metabolism; Rodents; Science; Science (multidisciplinary); Signal Transduction; Streptozocin; Transient receptor potential proteins; TRPC Cation Channels - deficiency; TRPC Cation Channels - genetics

Excess production of reactive oxygen species (ROS) caused by hyperglycemia is a major risk factor for heart failure. We previously reported that transient receptor potential canonical 3 (TRPC3) channel mediates pressure overload-induced maladaptive cardiac fibrosis by forming stably functional compl...